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CHEBI:15636 - (6R)-5,10-methylenetetrahydrofolate(2−)

ChEBI IDCHEBI:15636
ChEBI Name(6R)-5,10-methylenetetrahydrofolate(2−)
Stars
ASCII Name(6R)-5,10-methylenetetrahydrofolate(2-)
Secondary ChEBI IDsCHEBI:10925, CHEBI:18602
Last Modified25 July 2019
SubmitterMarcus Ennis
DownloadsMolfile
FormulaC20H21N7O6
Net Charge-2
Average Mass455.431
Monoisotopic Mass455.15643
SMILES[H][C@]12CNc3nc(N)nc(=O)c3N1CN(c1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])cc1)C2
InChIInChI=1S/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/p-2/t12-,13+/m1/s1
InChIKeyQYNUQALWYRSVHF-OLZOCXBDSA-L
Species of MetaboliteComponentSourceComments
Homo sapiens (ncbitaxon:9606) - DOI (10.1038/nbt.2488)
Roles Classification
Biological Roles:
human metabolite  Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
cofactor  An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
Saccharomyces cerevisiae metabolite  Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae ).
water-soluble vitamin (role)  Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine.
water-soluble vitamin (role)  Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine.
Applications:
nutraceutical  A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance.
nutraceutical  A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance.
ChEBI Ontology
Outgoing Relation(s)
(6R)-5,10-methylenetetrahydrofolate(2−) (CHEBI:15636) has role cofactor (CHEBI:23357)
(6R)-5,10-methylenetetrahydrofolate(2−) (CHEBI:15636) has role human metabolite (CHEBI:77746)
(6R)-5,10-methylenetetrahydrofolate(2−) (CHEBI:15636) is a 5,10-methylenetetrahydrofolate(2−) (CHEBI:12071)
(6R)-5,10-methylenetetrahydrofolate(2−) (CHEBI:15636) is conjugate base of (6R)-5,10-methylenetetrahydrofolic acid (CHEBI:1989)
Incoming Relation(s)
5,10-methylenetetrahydrofolate polyglutamate macromolecule (CHEBI:60473) has functional parent (6R)-5,10-methylenetetrahydrofolate(2−) (CHEBI:15636)
(6R)-5,10-methylenetetrahydrofolic acid (CHEBI:1989) is conjugate acid of (6R)-5,10-methylenetetrahydrofolate(2−) (CHEBI:15636)
IUPAC Name 
N-{4-[(6aR)-3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamate
Synonyms  Source
N-(5,10-methylene-5,6,7,8-tetrahydropteroyl)-L-glutamateChEBI
(6R)-5,10-CH2-H4folateJCBN
UniProt Name  Source
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateUniProt
Registry NumbersSources
Beilstein:5468618Beilstein