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CHEBI:176419 - FIN56

ChEBI IDCHEBI:176419
ChEBI NameFIN56
Stars
DefinitionA fluorene that is N-9H-fluoren-9-ylidenehydroxylamine substituted by N-cyclohexylsulfonyl groups at positions 2 and 7. It induces ferroptosis via degradation of GPX4 and also binds and activates squalene synthase.
Last Modified7 June 2021
SubmitterAdnan
DownloadsMolfile
FormulaC25H31N3O5S2
Net Charge0
Average Mass517.673
Monoisotopic Mass517.17051
SMILESO=S(=O)(NC1CCCCC1)c1ccc2c(c1)C(=NO)c1cc(S(=O)(=O)NC3CCCCC3)ccc1-2
InChIInChI=1S/C25H31N3O5S2/c29-26-25-23-15-19(34(30,31)27-17-7-3-1-4-8-17)11-13-21(23)22-14-12-20(16-24(22)25)35(32,33)28-18-9-5-2-6-10-18/h11-18,27-29H,1-10H2
InChIKeyJLCFMMIWBSZOIS-UHFFFAOYSA-N
Roles Classification
Biological Roles:
ferroptosis inducer  Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
EC 1.11.1.9 (glutathione peroxidase) inhibitor  An inhibitor of peroxidases (EC 1.11.1.*) that inhibits the action of glutathione peroxidase (EC 1.11.1.9).
xenobiotic  A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
ChEBI Ontology
Outgoing Relation(s)
FIN56 (CHEBI:176419) has functional parent 9-hydroxyiminofluorene-2,7-disulfonamide (CHEBI:114722)
FIN56 (CHEBI:176419) has role EC 1.11.1.9 (glutathione peroxidase) inhibitor (CHEBI:176342)
FIN56 (CHEBI:176419) has role ferroptosis inducer (CHEBI:173085)
FIN56 (CHEBI:176419) is a fluorenes (CHEBI:24059)
FIN56 (CHEBI:176419) is a ketoxime (CHEBI:24983)
FIN56 (CHEBI:176419) is a sulfonamide (CHEBI:35358)
IUPAC Name 
N,N'-dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
Synonyms  Source
FIN 56ChEBI
FIN-56ChEBI
N2,N7-dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamideIUPAC
Registry NumbersSources
CAS:1083162-61-1ChEBI
Citations