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CHEBI:173086 - ferrostatin-1

ChEBI IDCHEBI:173086
ChEBI Nameferrostatin-1
Stars
DefinitionAn ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals.
Last Modified26 May 2021
SubmitterAdnan
DownloadsMolfile
FormulaC15H22N2O2
Net Charge0
Average Mass262.353
Monoisotopic Mass262.16813
SMILESCCOC(=O)c1ccc(NC2CCCCC2)c(N)c1
InChIInChI=1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3
InChIKeyUJHBVMHOBZBWMX-UHFFFAOYSA-N
Roles Classification
Chemical Roles:
antioxidant  A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
radical scavenger  A role played by a substance that can react readily with, and thereby eliminate, radicals.
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
ferroptosis inhibitor  Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
antifungal agent  An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
Applications:
radiation protective agent  Any compound that is able to protect normal cells from the damage caused by radiation therapy.
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
ChEBI Ontology
Outgoing Relation(s)
ferrostatin-1 (CHEBI:173086) has role antifungal agent (CHEBI:35718)
ferrostatin-1 (CHEBI:173086) has role antioxidant (CHEBI:22586)
ferrostatin-1 (CHEBI:173086) has role ferroptosis inhibitor (CHEBI:173084)
ferrostatin-1 (CHEBI:173086) has role neuroprotective agent (CHEBI:63726)
ferrostatin-1 (CHEBI:173086) has role radiation protective agent (CHEBI:66987)
ferrostatin-1 (CHEBI:173086) has role radical scavenger (CHEBI:48578)
ferrostatin-1 (CHEBI:173086) is a ethyl ester (CHEBI:23990)
ferrostatin-1 (CHEBI:173086) is a primary arylamine (CHEBI:50471)
ferrostatin-1 (CHEBI:173086) is a substituted aniline (CHEBI:48975)
Incoming Relation(s)
SRS11-92 (CHEBI:173095) has functional parent ferrostatin-1 (CHEBI:173086)
IUPAC Name 
ethyl 3-amino-4-(cyclohexylamino)benzoate
Synonyms  Source
Fer-1ChEBI
3-amino-4-cyclohexylaminobenzoic acid ethyl esterChEBI
ferrrostatin 1ChEBI
Registry NumbersSources
CAS:347174-05-4ChEBI
Citations