brivanib (CHEBI:167686)

CHEBI:167686 - brivanib

ChEBI ID	CHEBI:167686
ChEBI Name	brivanib
Stars
Definition	A secondary alcohol resulting from the hydrolysis of the carboxylic ester group of brivanib alaninate. It is a dual VEGFR-2/FGFR-1 kinase inhibitor whose alanine prodrug, brivanib alaninate is currently under development as an oral agent for the treatment of cancer.
Last Modified	16 March 2021
Submitter	Adnan
Downloads	Molfile

Formula	C19H19FN4O3
Net Charge	0
Average Mass	370.384
Monoisotopic Mass	370.14412
SMILES	Cc1cc2c(F)c(Oc3ncnn4cc(OC[C@@H](C)O)c(C)c34)ccc2n1
InChI	InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1
InChIKey	WCWUXEGQKLTGDX-LLVKDONJSA-N

Roles Classification

fibroblast growth factor receptor antagonist An antagonist at the fibroblast growth factor receptor.

apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.

EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).

antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.

ChEBI Ontology

Outgoing Relation(s)
	brivanib (CHEBI:167686) has role angiogenesis inhibitor (CHEBI:48422)
	brivanib (CHEBI:167686) has role antineoplastic agent (CHEBI:35610)
	brivanib (CHEBI:167686) has role apoptosis inducer (CHEBI:68495)
	brivanib (CHEBI:167686) has role drug metabolite (CHEBI:49103)
	brivanib (CHEBI:167686) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
	brivanib (CHEBI:167686) has role fibroblast growth factor receptor antagonist (CHEBI:63457)
	brivanib (CHEBI:167686) is a aromatic ether (CHEBI:35618)
	brivanib (CHEBI:167686) is a diether (CHEBI:46786)
	brivanib (CHEBI:167686) is a fluoroindole (CHEBI:131960)
	brivanib (CHEBI:167686) is a pyrrolotriazine (CHEBI:88341)
	brivanib (CHEBI:167686) is a secondary alcohol (CHEBI:35681)
Incoming Relation(s)
Incoming Relation(s)	brivanib alaninate (CHEBI:167656) has functional parent brivanib (CHEBI:167686)

IUPAC Name
(2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-ol

Synonyms	Source
BMS-540215	ChemIDplus
BMS 540215	ChemIDplus
BMS540215	ChemIDplus
(R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol	ChEBI

Registry Numbers	Sources
CAS:649735-46-6	ChemIDplus

Citations