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CHEBI:167605 - 1,8-dihydroxynaphthalene-melanin
| ChEBI ID | CHEBI:167605 |
| ChEBI Name | 1,8-dihydroxynaphthalene-melanin |
| Stars | |
| Definition | A melanin pigment produced by certain fungi. It plays important roles in UV protection, oxidative stress and pathogenesis. In Aspergillus fumigatus, it is used as a virulence factor and plays an important role in the survival of the fungus during unfavorable conditions both in vivo and in vitro, and protects it from the host immune system. The pigment is generally synthesised from the pentaketide pathway in which 1,8-dihydroxynaphthalene is the immediate precursor which is polymerized to 1,8-dihydroxynaphthalene-melanin by a laccase enzyme. |
| Last Modified | 4 March 2021 |
| Submitter | Adnan |
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Passalora fulva (ncbitaxon:5499) | cell suspension culture (BTO:0000221) | PubMed (30582052) | |
| Exophiala dermatitidis (ncbitaxon:5970) | - | PubMed (11179356) | |
| Ascochyta rabiei (ncbitaxon:5454) | - | PubMed (20473673) | |
| Pseudocercospora griseola (ncbitaxon:687962) | - | PubMed (19306112) | |
| Trimmatostroma salinum (ncbitaxon:92990) | - | PubMed (15033240) | |
| Hortaea werneckii (ncbitaxon:91943) | - | PubMed (15033240) | |
| Neophaeotheca triangularis (ncbitaxon:92988) | - | PubMed (15033240) | |
| Aspergillus fumigatus (ncbitaxon:746128) | - | PubMed (24123270) | |
| Monosporascus cannonballus (ncbitaxon:155416) | - | PubMed (15212456) | |
| Exophiala pisciphila (ncbitaxon:86051) | - | PubMed (26467568) |
| Roles Classification |
|---|
| Biological Roles: | fungal metabolite Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds. Aspergillus metabolite Any fungal metabolite produced during a metabolic reaction in the mould, Aspergillus . virulence factor Any toxin secreted by bacteria, viruses, fungi or protozoa enabling them to achieve colonisation of a niche in the host, inhibit or evade the host's immune response, enter and exit cells, or obtain nutrition from the host. biological pigment An endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| 1,8-dihydroxynaphthalene-melanin (CHEBI:167605) has functional parent naphthalene-1,8-diol (CHEBI:167604) |
| 1,8-dihydroxynaphthalene-melanin (CHEBI:167605) has role Aspergillus metabolite (CHEBI:76956) |
| 1,8-dihydroxynaphthalene-melanin (CHEBI:167605) has role fungal metabolite (CHEBI:76946) |
| 1,8-dihydroxynaphthalene-melanin (CHEBI:167605) has role virulence factor (CHEBI:72316) |
| 1,8-dihydroxynaphthalene-melanin (CHEBI:167605) is a melanins (CHEBI:25179) |
| 1,8-dihydroxynaphthalene-melanin (CHEBI:167605) is a polyketide (CHEBI:26188) |
| Synonyms | Source |
|---|---|
| 1,8-dihydroxynaphthalene (DHN)-melanin | ChEBI |
| 1,8-DHN-melanin | ChEBI |
| 1,8-dihydroxynaphthalene melanin | ChEBI |
| 1,8-dihydroxynaphthalene (DHN) melanin | ChEBI |
| Citations |
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