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CHEBI:16684 - atropine
| Formula | C17H23NO3 |
| Net Charge | 0 |
| Average Mass | 289.375 |
| Monoisotopic Mass | 289.16779 |
| SMILES | CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(CO)c1ccccc1)C2 |
| InChI | InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16? |
| InChIKey | RKUNBYITZUJHSG-SPUOUPEWSA-N |
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Datura stramonium (ncbitaxon:4076) | - | PubMed (15374592) |
| Roles Classification |
|---|
| Biological Roles: | parasympatholytic Any cholinergic antagonist that inhibits the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the muscarinic antagonists. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria. insulin-sensitizing drug An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). |
| Applications: | bronchodilator agent An agent that causes an increase in the expansion of a bronchus or bronchial tubes. anaesthesia adjuvant Any substance that possesses little anaesthetic effect by itself, but which enhances or potentiates the anaesthetic action of other drugs when given at the same time. parasympatholytic Any cholinergic antagonist that inhibits the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the muscarinic antagonists. mydriatic agent Agent that dilates the pupil. Used in eye diseases and to facilitate eye examination. It may be either a sympathomimetic or parasympatholytic. The latter cause cycloplegia or paralysis of accommodation at high doses and may precipitate glaucoma. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antidote to sarin poisoning A role borne by a molecule that acts to counteract or neutralise the nerve agent sarin. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. antidote Any protective agent counteracting or neutralizing the action of poisons. anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. oneirogen Any substance that produces or enhances dream-like states of consciousness. vasoconstrictor agent Drug used to cause constriction of the blood vessels. ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases. hyperglycemic agent A drug which increases the blood glucose level. insulin-sensitizing drug An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). antidote to organophosphate poisoning A role borne by a molecule that acts to counteract or neutralise the deleterious effects of organophosphates or acetylcholinesterase inhibitors (nerve agents). |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| atropine (CHEBI:16684) has part (R)-atropine (CHEBI:48882) |
| atropine (CHEBI:16684) has part (S)-atropine (CHEBI:17486) |
| atropine (CHEBI:16684) has role anaesthesia adjuvant (CHEBI:60807) |
| atropine (CHEBI:16684) has role analgesic (CHEBI:35480) |
| atropine (CHEBI:16684) has role anti-arrhythmia drug (CHEBI:38070) |
| atropine (CHEBI:16684) has role antibacterial agent (CHEBI:33282) |
| atropine (CHEBI:16684) has role antidote (CHEBI:50247) |
| atropine (CHEBI:16684) has role antidote to organophosphate poisoning (CHEBI:90753) |
| atropine (CHEBI:16684) has role antidote to sarin poisoning (CHEBI:136860) |
| atropine (CHEBI:16684) has role antineoplastic agent (CHEBI:35610) |
| atropine (CHEBI:16684) has role bronchodilator agent (CHEBI:35523) |
| atropine (CHEBI:16684) has role cardiovascular drug (CHEBI:35554) |
| atropine (CHEBI:16684) has role hyperglycemic agent (CHEBI:76916) |
| atropine (CHEBI:16684) has role insulin-sensitizing drug (CHEBI:50864) |
| atropine (CHEBI:16684) has role muscarinic antagonist (CHEBI:48876) |
| atropine (CHEBI:16684) has role mydriatic agent (CHEBI:50513) |
| atropine (CHEBI:16684) has role oneirogen (CHEBI:146270) |
| atropine (CHEBI:16684) has role ophthalmology drug (CHEBI:66981) |
| atropine (CHEBI:16684) has role parasympatholytic (CHEBI:50370) |
| atropine (CHEBI:16684) has role plant metabolite (CHEBI:76924) |
| atropine (CHEBI:16684) has role vasoconstrictor agent (CHEBI:50514) |
| atropine (CHEBI:16684) is a racemate (CHEBI:60911) |
| Incoming Relation(s) |
| (6S)-6-hydroxyhyoscyamine (CHEBI:15645) has functional parent atropine (CHEBI:16684) |
| atropine sulfate (CHEBI:233047) has functional parent atropine (CHEBI:16684) |
| hyoscyamine sulfate dihydrate (CHEBI:28486) has functional parent atropine (CHEBI:16684) |
| IUPAC Names |
|---|
| rac-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate |
| rac-tropan-3α-yl 3-hydroxy-2-phenylpropanoate |
| Synonyms | Source |
|---|---|
| [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate | IUPHAR |
| (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate | ChEBI |
| 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate | ChEBI |
| 8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate | NIST Chemistry WebBook |
| Atropin | ChemIDplus |
| atropina | ChEBI |
| Brand Names | Source |
|---|---|
| Atroject | ChEMBL |
| Atropen | ChEMBL |
| Atrophate | ChEMBL |
| Atropine (autoinjector) | ChEMBL |
| Atropine component of atnaa | ChEMBL |
| Atropine component of duodote | ChEMBL |
| Citations |
|---|