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CHEBI:147347 - tilorone

ChEBI IDCHEBI:147347
ChEBI Nametilorone
Stars
DefinitionA member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective α7 nicotinic acetylcholine receptor (α7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.
Secondary ChEBI IDCHEBI:109553
Last Modified10 May 2024
SubmitterAdnan
DownloadsMolfile
FormulaC25H34N2O3
Net Charge0
Average Mass410.558
Monoisotopic Mass410.25694
SMILESCCN(CC)CCOc1ccc2c(c1)C(=O)c1cc(OCCN(CC)CC)ccc1-2
InChIInChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3
InChIKeyMPMFCABZENCRHV-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
nicotinic acetylcholine receptor agonist  An agonist that selectively binds to and activates a nicotinic acetylcholine receptor.
EC 3.1.1.7 (acetylcholinesterase) inhibitor  An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
antiviral agent  A substance that destroys or inhibits replication of viruses.
xenobiotic  A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
nicotinic acetylcholine receptor agonist  An agonist that selectively binds to and activates a nicotinic acetylcholine receptor.
interferon inducer  An agent that promotes the production and release of interferons.
anti-inflammatory agent  Any compound that has anti-inflammatory effects.
ChEBI Ontology
Outgoing Relation(s)
tilorone (CHEBI:147347) has role anti-inflammatory agent (CHEBI:67079)
tilorone (CHEBI:147347) has role antineoplastic agent (CHEBI:35610)
tilorone (CHEBI:147347) has role antiviral agent (CHEBI:22587)
tilorone (CHEBI:147347) has role EC 3.1.1.7 (acetylcholinesterase) inhibitor (CHEBI:38462)
tilorone (CHEBI:147347) has role interferon inducer (CHEBI:36710)
tilorone (CHEBI:147347) has role nicotinic acetylcholine receptor agonist (CHEBI:47958)
tilorone (CHEBI:147347) is a aromatic ether (CHEBI:35618)
tilorone (CHEBI:147347) is a diether (CHEBI:46786)
tilorone (CHEBI:147347) is a fluoren-9-ones (CHEBI:24057)
tilorone (CHEBI:147347) is a tertiary amino compound (CHEBI:50996)
tilorone (CHEBI:147347) is conjugate base of tilorone(2+) (CHEBI:147355)
Incoming Relation(s)
tilorone(2+) (CHEBI:147355) is conjugate acid of tilorone (CHEBI:147347)
IUPAC Name 
2,7-bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one
INNs  Source
tiloronumWHO MedNet
tiloronaWHO MedNet
tiloroneWHO MedNet
tiloroneWHO MedNet
Synonym  Source
2,7-bis[2-(diethylamino)ethoxy]-9-fluorenoneChEBI
Manual XrefsDatabases
LSM-20974LINCS
TiloroneWikipedia
DB17965DrugBank
HMDB0259096HMDB
Registry NumbersSources
CAS:27591-97-5ChemIDplus
Citations