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CHEBI:145332 - 1',4-dihydroxymidazolam

ChEBI IDCHEBI:145332
ChEBI Name1',4-dihydroxymidazolam
Stars
DefinitionAn imidazobenzodiazepine that is midazolam which is substituted by a hydroxy group at positions 2 and 4. It is the minor metabolite of the anesthetic, midazolam.
Last Modified11 November 2019
SubmitterAdnan
DownloadsMolfile
FormulaC18H13ClFN3O2
Net Charge0
Average Mass357.772
Monoisotopic Mass357.06803
SMILESOCc1ncc2n1-c1ccc(Cl)cc1C(c1ccccc1F)=NC2O
InChIInChI=1S/C18H13ClFN3O2/c19-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)20)22-18(25)15-8-21-16(9-24)23(14)15/h1-8,18,24-25H,9H2
InChIKeyOJDUJEPGFILARE-UHFFFAOYSA-N
Roles Classification
Biological Roles:
GABA modulator  A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
Application:
GABA modulator  A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
ChEBI Ontology
Outgoing Relation(s)
1',4-dihydroxymidazolam (CHEBI:145332) has functional parent midazolam (CHEBI:6931)
1',4-dihydroxymidazolam (CHEBI:145332) has role drug metabolite (CHEBI:49103)
1',4-dihydroxymidazolam (CHEBI:145332) is a aromatic primary alcohol (CHEBI:33857)
1',4-dihydroxymidazolam (CHEBI:145332) is a imidazobenzodiazepine (CHEBI:142118)
1',4-dihydroxymidazolam (CHEBI:145332) is a monofluorobenzenes (CHEBI:83575)
1',4-dihydroxymidazolam (CHEBI:145332) is a organochlorine compound (CHEBI:36683)
IUPAC Name 
8-chloro-6-(2-fluorophenyl)-1-(hydroxymethyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol
Synonyms  Source
8-chloro-6-(2-fluorophenyl)-4-hydroxy-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanolChEBI
1,4-dihydroxymidazolamChEBI
1,4-dihydroxy midazolamChEBI
1',4-dihydroxy midazolamChEBI
1',4'-dihydroxymidazolamChEBI
Ro 21-0284ChEBI
Registry NumbersSources
CAS:64740-68-7ChEBI
Citations