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CHEBI:145331 - 4-hydroxymidazolam
| Formula | C18H13ClFN3O |
| Net Charge | 0 |
| Average Mass | 341.773 |
| Monoisotopic Mass | 341.07312 |
| SMILES | Cc1ncc2n1-c1ccc(Cl)cc1C(c1ccccc1F)=NC2O |
| InChI | InChI=1S/C18H13ClFN3O/c1-10-21-9-16-18(24)22-17(12-4-2-3-5-14(12)20)13-8-11(19)6-7-15(13)23(10)16/h2-9,18,24H,1H3 |
| InChIKey | ZYISITHKPKHPKG-UHFFFAOYSA-N |
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Homo sapiens (ncbitaxon:9606) | |||
| blood plasma (BTO_0000131) | PubMed (15018796) | ||
| blood serum (BTO:0000133) | PubMed (9187388) | ||
| urine (BTO:0001419) | PubMed (31474719) |
| Roles Classification |
|---|
| Biological Roles: | human urinary metabolite Any metabolite (endogenous or exogenous) found in human urine samples. human blood serum metabolite Any metabolite (endogenous or exogenous) found in human blood serum samples. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| Application: | GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| 4-hydroxymidazolam (CHEBI:145331) has functional parent midazolam (CHEBI:6931) |
| 4-hydroxymidazolam (CHEBI:145331) has role drug metabolite (CHEBI:49103) |
| 4-hydroxymidazolam (CHEBI:145331) has role human blood serum metabolite (CHEBI:85234) |
| 4-hydroxymidazolam (CHEBI:145331) has role human urinary metabolite (CHEBI:84087) |
| 4-hydroxymidazolam (CHEBI:145331) is a imidazobenzodiazepine (CHEBI:142118) |
| 4-hydroxymidazolam (CHEBI:145331) is a monofluorobenzenes (CHEBI:83575) |
| 4-hydroxymidazolam (CHEBI:145331) is a organic hydroxy compound (CHEBI:33822) |
| 4-hydroxymidazolam (CHEBI:145331) is a organochlorine compound (CHEBI:36683) |
| Incoming Relation(s) |
| 4-hydroxymidazolam β-D-glucuronide (CHEBI:145335) has functional parent 4-hydroxymidazolam (CHEBI:145331) |
| IUPAC Name |
|---|
| 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol |
| Synonyms | Source |
|---|---|
| 4-OH-MDZ | ChemIDplus |
| 4-OH midazolam | ChEBI |
| Ro 21-5975 | ChEBI |
| Manual Xrefs | Databases |
|---|---|
| HMDB0061090 | HMDB |
| Registry Numbers | Sources |
|---|---|
| CAS:59468-85-8 | ChemIDplus |
| CAS:59468-85-8 | NIST Chemistry WebBook |
| Citations |
|---|