EMBL-EBI | Chemical Biology | ChEBI
Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search
CHEBI:145330 - 1-hydroxymidazolam
| Formula | C18H13ClFN3O |
| Net Charge | 0 |
| Average Mass | 341.773 |
| Monoisotopic Mass | 341.07312 |
| SMILES | OCc1ncc2n1-c1ccc(Cl)cc1C(c1ccccc1F)=NC2 |
| InChI | InChI=1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2 |
| InChIKey | QHSMEGADRFZVNE-UHFFFAOYSA-N |
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Homo sapiens (ncbitaxon:9606) | |||
| blood plasma (BTO_0000131) | PubMed (15914101) | ||
| blood serum (BTO:0000133) | PubMed (9187388) | ||
| urine (BTO:0001419) | PubMed (31474719) |
| Roles Classification |
|---|
| Biological Roles: | human urinary metabolite Any metabolite (endogenous or exogenous) found in human urine samples. human blood serum metabolite Any metabolite (endogenous or exogenous) found in human blood serum samples. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| Application: | GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| 1-hydroxymidazolam (CHEBI:145330) has functional parent midazolam (CHEBI:6931) |
| 1-hydroxymidazolam (CHEBI:145330) has role drug metabolite (CHEBI:49103) |
| 1-hydroxymidazolam (CHEBI:145330) has role human blood serum metabolite (CHEBI:85234) |
| 1-hydroxymidazolam (CHEBI:145330) has role human urinary metabolite (CHEBI:84087) |
| 1-hydroxymidazolam (CHEBI:145330) is a aromatic primary alcohol (CHEBI:33857) |
| 1-hydroxymidazolam (CHEBI:145330) is a imidazobenzodiazepine (CHEBI:142118) |
| 1-hydroxymidazolam (CHEBI:145330) is a monofluorobenzenes (CHEBI:83575) |
| 1-hydroxymidazolam (CHEBI:145330) is a organochlorine compound (CHEBI:36683) |
| Incoming Relation(s) |
| 1-hydroxymidazolam β-D-glucuronide (CHEBI:145334) has functional parent 1-hydroxymidazolam (CHEBI:145330) |
| IUPAC Name |
|---|
| [8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-1-yl]methanol |
| Synonyms | Source |
|---|---|
| α-hydroxymidazolam | ChemIDplus |
| 8-chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5-a][1,4]benzodiazepine | ChEBI |
| 1'-hydroxymidazolam | ChEBI |
| 1-OH-MDZ | ChemIDplus |
| 8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol | ChEBI |
| 1-hydroxymethylmidazolam | ChemIDplus |
| Manual Xrefs | Databases |
|---|---|
| HMDB0061089 | HMDB |
| Registry Numbers | Sources |
|---|---|
| CAS:59468-90-5 | ChemIDplus |
| Citations |
|---|