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CHEBI:140464 - 7,8-dihydroxyflavone

ChEBI IDCHEBI:140464
ChEBI Name7,8-dihydroxyflavone
Stars
DefinitionA dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A naturally occurring flavonoid produced by several plants, including the weed Tridax procumbens (coalbuttons or tridax daisy) and the tree Godmania aesculifolia, In animal models, it has shown efficacy against several diseases of the nervous system, including Alzheimer's, Parkinson's, and Huntington's.
Last Modified29 July 2022
SubmitterTheOtherDave
DownloadsMolfile
FormulaC15H10O4
Net Charge0
Average Mass254.241
Monoisotopic Mass254.05791
SMILESO=c1cc(-c2ccccc2)oc2c(O)c(O)ccc12
InChIInChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
InChIKeyCOCYGNDCWFKTMF-UHFFFAOYSA-N
Wikipedia
Species of MetaboliteComponentSourceComments
Lepisorus ussuriensis (ncbitaxon:699700) whole plant (BTO:0001461) PubMed (26569039)
Primula halleri (ncbitaxon:175072) leaf (BTO:0000713) PubMed (24345641)
Tridax procumbens (ncbitaxon:318066) - Article (Int. J. Med. Arom. Plants, 2012, 2, 185-194.)
Roles Classification
Chemical Role:
antioxidant  A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
Biological Roles:
plant metabolite  Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
tropomyosin-related kinase B receptor agonist  An agonist that binds to and deactivates the tropomyosin-related kinase B (TrkB) receptor, the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF).
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
antidepressant  Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
ChEBI Ontology
Outgoing Relation(s)
7,8-dihydroxyflavone (CHEBI:140464) has role antidepressant (CHEBI:35469)
7,8-dihydroxyflavone (CHEBI:140464) has role antineoplastic agent (CHEBI:35610)
7,8-dihydroxyflavone (CHEBI:140464) has role antioxidant (CHEBI:22586)
7,8-dihydroxyflavone (CHEBI:140464) has role plant metabolite (CHEBI:76924)
7,8-dihydroxyflavone (CHEBI:140464) has role tropomyosin-related kinase B receptor agonist (CHEBI:140489)
7,8-dihydroxyflavone (CHEBI:140464) is a dihydroxyflavone (CHEBI:38686)
Incoming Relation(s)
7,8-dimethoxyflavone (CHEBI:192767) has functional parent 7,8-dihydroxyflavone (CHEBI:140464)
IUPAC Name 
7,8-dihydroxy-2-phenyl-4H-chromen-4-one
Synonyms  Source
7,8-DHFSUBMITTER
7,8-dihydroxy-2-phenyl-4-benzopyroneChemIDplus
7,8-dihydroxy-2-phenylchromoneChEBI
Manual XrefsDatabases
329798806PubChem Compound
7,8-DihydroxyflavoneWikipedia
Registry NumbersSources
Reaxys:234350Reaxys
CAS:38183-03-8ChemIDplus
Citations