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CHEBI:135653 - taltirelin

Default Structure
ChEBI IDCHEBI:135653
ChEBI Nametaltirelin
Stars
DefinitionAn oligopeptide comprising of (4S)-1-methyl-2,6-dioxohexahydropyrimidine-4-carboxylic acid, L-histidine and L-prolinamide joined in sequence by peptide linkages. It is a thyrotropin-releasing hormone (TRH) analog. Its tetrahydrate form is approved in Japan for the treatment of spinal muscular atrophy.
Last Modified23 November 2020
DownloadsMolfile
FormulaC17H23N7O5
Net Charge0
Average Mass405.415
Monoisotopic Mass405.17607
SMILESCN1C(=O)C[C@@H](C(=O)N[C@@H](Cc2cncn2)C(=O)N2CCC[C@H]2C(N)=O)NC1=O
InChIInChI=1S/C17H23N7O5/c1-23-13(25)6-10(22-17(23)29)15(27)21-11(5-9-7-19-8-20-9)16(28)24-4-2-3-12(24)14(18)26/h7-8,10-12H,2-6H2,1H3,(H2,18,26)(H,19,20)(H,21,27)(H,22,29)/t10-,11-,12-/m0/s1
InChIKeyLQZAIAZUDWIVPM-SRVKXCTJSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
analgesic  An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
Applications:
analgesic  An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
nootropic agent  Any compound that improves mental functions such as cognition, memory, intelligence, motivation, attention, and concentration.
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
ChEBI Ontology
Outgoing Relation(s)
taltirelin (CHEBI:135653) has role analgesic (CHEBI:35480)
taltirelin (CHEBI:135653) has role neuroprotective agent (CHEBI:63726)
taltirelin (CHEBI:135653) has role nootropic agent (CHEBI:66980)
taltirelin (CHEBI:135653) is a oligopeptide (CHEBI:25676)
Incoming Relation(s)
taltirelin tetrahydrate (CHEBI:157598) has part taltirelin (CHEBI:135653)
IUPAC Name 
N-{[(4S)-1-methyl-2,6-dioxohexahydropyrimidin-4-yl]carbonyl}-L-histidyl-L-prolinamide
INNs  Source
taltirelinWHO MedNet
taltirelinaWHO MedNet
taltirélineWHO MedNet
taltirelinumWHO MedNet
Synonyms  Source
1-methyl-(S)-4,5-dihydroorotyl-L-histidyl-L-prolinamideChEBI
TA 0910DrugCentral
TA-0910DrugCentral
Manual XrefsDatabases
102734ChemSpider
2560DrugCentral
TaltirelinWikipedia
Registry NumbersSources
CAS:103300-74-9ChemIDplus
Citations