EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:132754 - dynasore

ChEBI IDCHEBI:132754
ChEBI Namedynasore
Stars
DefinitionA carbohydrazide resulting from the formal condensation of the hydrazone moiety of 3,4-dihydroxybenzaldehyde hydrazone with the carboxy group of 3-hydroxy-2-naphthoic acid. It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity of dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42.
Last Modified20 July 2016
Submittersabrina, zfin
DownloadsMolfile
FormulaC18H14N2O4
Net Charge0
Average Mass322.320
Monoisotopic Mass322.09536
SMILESO=C(N/N=C/c1ccc(O)c(O)c1)c1cc2ccccc2cc1O
InChIInChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
InChIKeySYNDQCRDGGCQRZ-VXLYETTFSA-N
Roles Classification
Biological Role:
EC 3.6.5.5 (dynamin GTPase) inhibitor  An EC 3.6.5.* (hydrolases acting on GTP; involved in cellular and subcellular movement) inhibitor that interferes with the action of dynamin GTPase (EC 3.6.5.5).
ChEBI Ontology
Outgoing Relation(s)
dynasore (CHEBI:132754) has functional parent 3-Hydroxy-2-naphthoate (CHEBI:80383)
dynasore (CHEBI:132754) has role EC 3.6.5.5 (dynamin GTPase) inhibitor (CHEBI:132772)
dynasore (CHEBI:132754) is a catechols (CHEBI:33566)
dynasore (CHEBI:132754) is a hydrazide (CHEBI:35362)
dynasore (CHEBI:132754) is a hydrazone (CHEBI:38532)
dynasore (CHEBI:132754) is a naphthols (CHEBI:25392)
IUPAC Name 
N'-[(E)-(3,4-dihydroxyphenyl)methylene]-3-hydroxy-2-naphthohydrazide
Synonyms  Source
Dynamin Inhibitor ISUBMITTER
3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazideSUBMITTER
Registry NumbersSources
Reaxys:25249841Reaxys
Reaxys:20640593Reaxys
CAS:304448-55-3SUBMITTER
Citations