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CHEBI:131848 - fotemustine

ChEBI IDCHEBI:131848
ChEBI Namefotemustine
Stars
DefinitionA racemate comprising equimolar amounts of (R)- and (S)-fotemustine. It is an alkylating agent used in the treatment of malignant melanoma.
Last Modified22 February 2017
FormulaC9H19ClN3O5P
Net Charge0
Average Mass315.691
Monoisotopic Mass315.07509
Wikipedia
Roles Classification
Biological Role:
alkylating agent  Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
fotemustine (CHEBI:131848) has part (R)-fotemustine (CHEBI:131853)
fotemustine (CHEBI:131848) has part (S)-fotemustine (CHEBI:131854)
fotemustine (CHEBI:131848) has role alkylating agent (CHEBI:22333)
fotemustine (CHEBI:131848) has role antineoplastic agent (CHEBI:35610)
fotemustine (CHEBI:131848) is a racemate (CHEBI:60911)
INNs  Source
fotemustinaWHO MedNet
fotemustineWHO MedNet
fotémustineWHO MedNet
fotemustinumWHO MedNet
Synonyms  Source
(±)-diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonateChEBI
diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonateChemIDplus
rac-fotemustineChEBI
S 10036ChemIDplus
Servier-10036ChemIDplus
Brand Names  Source
MuphoranKEGG DRUG
MustoforanChemIDplus
Manual XrefsDatabases
D07255KEGG DRUG
FotemustineWikipedia
FR2536075Patent
US4567169Patent
Registry NumbersSources
Reaxys:8626774Reaxys
CAS:92118-27-9ChemIDplus
Citations