S-BIAD453alpha

The expression of cancer-testis antigens is associated with immune cell infiltration in the microenvironment of non-small cell lung cancer

Released 2023-02-07
Feria Hikmet Noraddin, Cecilia Lindskog

Content

  • 128 images
  • Study size: 24.5GiB
  • N files: 64
  • Filetype breakdown:
    • .svs: 64 (24.5GiB)
Patients diagnosed with non-small cell lung cancer (NSCLC) have access to immune checkpoint inhibitors which are now routinely used in medical care. However, durable benefits are only measured in a minority of patients. A tumor's antigenic landscape (tumor-associated antigens, TAAs) can be utilized for anticancer immune response, and cancer-testis antigens (CTAs) are known targets of humoral and cellular immune reactions. The current study aimed to characterize CTA expression in non-small cell lung cancer (NSCLC) in the relation to the immune microenvironment. Here, we present the raw image data for eight cancer-testis antigens (DPEP3, EZHIP, MAGEA4, MAGEB2, MAGEC2, PAGE1, PRAME, and TKTL1) that were selected for detailed immunohistochemical protein profiling in 1-millimeter tissue punch-outs from 328 NSCLC patients.

Study information

Organism
Homo sapiens (human)
Imaging type
bright-field microscopy
License
CC0

Viewable images

Image ID Preview Filename Dimensions
(T, C, Z, Y, X)		 Download Size Actions
IM1 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide1.svs (1, 3, 1, 41717, 47808) Unavailable
0f0d4e14-7d08-4035-b68c-636334e43de2 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide2.svs (1, 3, 1, 41233, 49800) 424.9MiB
0ea9a89a-892b-47d3-86cc-85971288943a TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide6.svs (1, 3, 1, 39944, 49800) 366.5MiB
00f585ec-9ee1-4d32-8586-cc4c9178ca55 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide3.svs (1, 3, 1, 42281, 45816) 412.5MiB
0c32cc51-b73a-4f7d-97c8-9ebdadf6b57e TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide1.svs (1, 3, 1, 42925, 49800) 399.6MiB
03b7e5e4-68db-415b-a6ad-624fed7882c8 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide5.svs (1, 3, 1, 40508, 47808) 392.2MiB
0a8bf66c-0eb0-4240-9776-02c05ab54601 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide8.svs (1, 3, 1, 35271, 47808) 274.7MiB

All images

Image ID Filename Download Size Actions
IM1 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide1.svs Unavailable Download
IM2 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide2.svs Unavailable Download
IM3 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide3.svs Unavailable Download
IM4 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide4.svs Unavailable Download
IM5 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide5.svs Unavailable Download
IM6 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide6.svs Unavailable Download
IM7 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide7.svs Unavailable Download
IM8 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide8.svs Unavailable Download
IM9 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide1.svs Unavailable Download
IM10 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide2.svs Unavailable Download
IM11 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide3.svs Unavailable Download
IM12 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide4.svs Unavailable Download
IM13 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide5.svs Unavailable Download
IM14 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide6.svs Unavailable Download
IM15 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide7.svs Unavailable Download
IM16 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide8.svs Unavailable Download
IM17 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide1.svs Unavailable Download
IM18 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide2.svs Unavailable Download
IM19 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide3.svs Unavailable Download
IM20 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide4.svs Unavailable Download
IM21 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide5.svs Unavailable Download
IM22 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide6.svs Unavailable Download
IM23 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide7.svs Unavailable Download
IM24 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide8.svs Unavailable Download
IM25 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide1.svs Unavailable Download
IM26 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide2.svs Unavailable Download
IM27 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide3.svs Unavailable Download
IM28 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide4.svs Unavailable Download
IM29 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide5.svs Unavailable Download
IM30 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide6.svs Unavailable Download
IM31 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide7.svs Unavailable Download
IM32 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide8.svs Unavailable Download
IM33 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide1.svs Unavailable Download
IM34 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide2.svs Unavailable Download
IM35 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide3.svs Unavailable Download
IM36 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide4.svs Unavailable Download
IM37 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide5.svs Unavailable Download
IM38 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide6.svs Unavailable Download
IM39 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide7.svs Unavailable Download
IM40 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide8.svs Unavailable Download
IM41 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide1.svs Unavailable Download
IM42 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide2.svs Unavailable Download
IM43 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide3.svs Unavailable Download
IM44 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide4.svs Unavailable Download
IM45 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide5.svs Unavailable Download
IM46 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide6.svs Unavailable Download
IM47 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide7.svs Unavailable Download
IM48 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide8.svs Unavailable Download
IM49 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide1.svs Unavailable Download
IM50 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide2.svs Unavailable Download
IM51 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide3.svs Unavailable Download
IM52 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide4.svs Unavailable Download
IM53 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide5.svs Unavailable Download
IM54 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide6.svs Unavailable Download
IM55 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide7.svs Unavailable Download
IM56 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide8.svs Unavailable Download
IM57 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide1.svs Unavailable Download
IM58 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide2.svs Unavailable Download
IM59 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide3.svs Unavailable Download
IM60 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide4.svs Unavailable Download
IM61 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide5.svs Unavailable Download
IM62 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide6.svs Unavailable Download
IM63 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide7.svs Unavailable Download
IM64 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide8.svs Unavailable Download
0f0d4e14-7d08-4035-b68c-636334e43de2 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide2.svs 424.9MiB Download
36404075-3705-4649-913a-032180624870 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide8.svs 259.3MiB Download
0ea9a89a-892b-47d3-86cc-85971288943a TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide6.svs 366.5MiB Download
2dd8bc04-ba76-4678-b73a-d553b0730617 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide3.svs 409.5MiB Download
660a7d07-6430-43c3-9228-c552894a3271 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide8.svs 257.8MiB Download
f27767db-6f7b-4e1b-866a-0515217a9d7d MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide2.svs 418.1MiB Download
a1bd1745-94a6-48bd-b72e-9d796539fa45 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide7.svs 348.0MiB Download
711d0cd4-c5f3-4268-9632-d7e627505e32 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide7.svs 380.1MiB Download
40821cba-7b91-49b5-a1ee-ad09468b3ed1 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide2.svs 418.9MiB Download
a28ab650-1276-4454-b687-0ab051b29fa2 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide6.svs 367.3MiB Download
22b097ac-82f6-43b0-bb89-2266a5dfcd4c MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide3.svs 493.5MiB Download
9c45b811-aa90-4760-8f74-6428b9e5c70d MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide7.svs 348.1MiB Download
da2f5ee0-631f-4d1d-a26a-38c005bc1161 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide7.svs 366.8MiB Download
88ed7bec-06cc-404e-8be4-aa5d267210aa EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide5.svs 454.1MiB Download
1906e1bf-c2d6-4fe4-8d05-806277431055 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide7.svs 383.0MiB Download
da8f5ffa-efc9-4c15-8d2f-0d8cbddfc005 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide8.svs 259.4MiB Download
f340ef1f-a0ac-4fe6-94cf-b1cbc1fbcdca MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide4.svs 408.2MiB Download
37ffaebc-592b-40ba-a78b-2c35394ddcd6 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide2.svs 411.3MiB Download
3025733d-8808-402e-9a5f-579463209a30 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide6.svs 373.0MiB Download
1014f2e9-4e5d-4928-8ba5-06f52070cba4 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide8.svs 245.2MiB Download
923a7a86-ca60-4423-8e0e-adcb7d29a07c PRAME/PRAME_(HPA045153)_1300_BOMI2_slide3.svs 455.9MiB Download
c9ae582d-28a0-49c6-8e19-5e86714c794b EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide1.svs 427.9MiB Download
ee2a8d71-7011-4dda-84d8-a6f19d8b7897 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide6.svs 383.2MiB Download
353439b2-e564-4549-b51d-9b3c7b53a224 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide8.svs 265.3MiB Download
3430a778-63da-4dd9-87fd-f9e06f9ab56e MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide1.svs 440.6MiB Download
c327e75b-2b1b-4ac5-9fa3-62091b4b2a20 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide1.svs 432.5MiB Download
e7eadab1-ca5b-4dcf-ad3b-6a53e52b8a29 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide3.svs 468.3MiB Download
78e72412-dfe8-4f6c-a409-07d17e87bb16 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide4.svs 439.6MiB Download
e46aaa14-b83a-441f-a211-f7d08edf3bba MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide5.svs 393.3MiB Download
c6a53ebd-e623-408c-ad8a-b893e4c525cd EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide2.svs 680.1MiB Download
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9bd4bf52-127f-41ec-9af9-7e92c0239857 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide1.svs 396.8MiB Download
fdebc96e-c5e8-41a9-b495-2fe0f7c99fec PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide5.svs 409.4MiB Download
912ce3ef-2b93-4ce8-b98b-40eb71118106 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide7.svs 331.8MiB Download
c7fe0977-fed0-4ae0-8bb9-c5aab7260299 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide4.svs 395.7MiB Download
90847ea9-3546-4e25-a6f2-28eb1a35b9ba MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide7.svs 342.0MiB Download
00f585ec-9ee1-4d32-8586-cc4c9178ca55 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide3.svs 412.5MiB Download
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d19d4262-955d-46ba-a15f-25d77c86373d TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide7.svs 348.3MiB Download
df682e19-0a04-4275-8346-d3f640adabe2 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide2.svs 426.0MiB Download
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29b23aca-9e82-497e-9390-611fae0f5d9b TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide4.svs 359.0MiB Download
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0c32cc51-b73a-4f7d-97c8-9ebdadf6b57e TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide1.svs 399.6MiB Download
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0f6201d4-1308-424b-ad33-4216d72c75c5 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide1.svs 441.0MiB Download
f1d36bd9-d944-41be-8ea8-384f6979923e PRAME/PRAME_(HPA045153)_1300_BOMI2_slide4.svs 406.9MiB Download
71230912-c9b3-4aca-b773-5a042547618b TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide2.svs 429.8MiB Download
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f175a825-0ea7-40ce-a63e-4f2de49ebd41 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide6.svs 345.1MiB Download
214d0768-11d1-456f-8401-a21bb9597d0c MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide5.svs 430.6MiB Download
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4524c761-f822-4ffe-8de3-bcf5cd3af07d DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide3.svs 432.5MiB Download