DECIPHER v11.27 release
The v11.27 DECIPHER release is out now. Find out about the new features and improvements
UTRannotator scores
UTRannotator scores are now displayed on annotation tabs. UTRannotator provides annotations for variants in 5’untranslated regions (5’UTRs) that create or disrupt upstream open reading frames (uORFs), which are tissue-specific cis-regulators of protein translation.
The creation or disruption of uORFs have been shown to cause some diseases. UTRannotator provides the predicted consequence of a variant, along with annotations, including the strength and context of the Kozak sequence, the type of uORF being created/lost and positional information.
gnomAD
The gnomAD structural variant genome track has been updated to gnomAD v4.1. This track displays 1,199,117 high-quality structural variants identified in 63,046 genomes from unrelated individuals. The following track filters are available: gains only, losses only, insertions/ complex/ others.
Regional missense constraint data
Regional missense constraint data has been updated to gnomAD v2.1.1. This data is displayed in genome and protein browser tracks. Genes or regions with significantly less missense variation than expected, i.e. more constrained, may represent genes where natural selection most aggressively removes variation.
