PDBsum entry 3pup

Transferase

PDB id: 3pup

Contents

Protein chains

346 a.a. *

Ligands

OS1 ×2

* Residue conservation analysis

PDB id:

3pup

Name:

Transferase

Title:

Structure of glycogen synthase kinase 3 beta (gsk3b) in complex with a ruthenium octasporine ligand (os1)

Structure:

Glycogen synthase kinase-3 beta. Chain: a, b. Synonym: gsk-3 beta. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gsk3b. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.99Å R-factor: 0.206 R-free: 0.249

Authors:

P.Filippakopoulos,K.Kraling,L.O.Essen,E.Meggers,S.Knapp

Key ref:

L.Feng et al. (2011). Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors. J Am Chem Soc, 133, 5976-5986. PubMed id: 21446733

Date:

06-Dec-10 Release date: 22-Dec-10

Protein chains

P49841  (GSK3B_HUMAN) -  Glycogen synthase kinase-3 beta from Homo sapiens

Seq: 420 a.a.

Struc: 346 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.26 - [tau protein] kinase.
• Reaction:
  1. L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H⁺
  2. L-threonyl-[tau protein] + ATP = O-phospho-L-threonyl-[tau protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

J Am Chem Soc 133:5976-5986 (2011)

PubMed id: 21446733

Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors.

L.Feng, Y.Geisselbrecht, S.Blanck, A.Wilbuer, G.E.Atilla-Gokcumen, P.Filippakopoulos, K.Kräling, M.A.Celik, K.Harms, J.Maksimoska, R.Marmorstein, G.Frenking, S.Knapp, L.O.Essen, E.Meggers.

ABSTRACT

No abstract given.