EC 2.7.11.26 - [tau protein] kinase

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IntEnz Enzyme Nomenclature
EC 2.7.11.26

Names

Accepted name:
[tau protein] kinase
Other names:
[tau-protein] kinase
ATP:tau-protein O-phosphotransferase
brain protein kinase PK40erk
cdk5/p20
CDK5/p23
glycogen synthase kinase-3β
GSK
protein tau kinase
STK31
tau kinase
tau-protein kinase I
tau-protein kinase II
tau-tubulin kinase
TPK
TPK I
TPK II
TTK
Systematic name:
ATP:[tau-protein] O-phosphotransferase

Reactions

Comments:

Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00100
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050321
CAS Registry Number: 111694-09-8
UniProtKB/Swiss-Prot: (40) [show] [UniProt]

References

  1. Ishiguro, K., Ihara, Y., Uchida, T. and Imahori, K.
    A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau.
    J. Biochem. (Tokyo) 104: 319-321 (1988). [PMID: 2467901]
  2. Lund, E.T., McKenna, R., Evans, D.B., Sharma, S.K. and Mathews, W.R.
    Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry.
    J. Neurochem. 76: 1221-1232 (2001). [PMID: 11181841]
  3. Michel, G., Mercken, M., Murayama, M., Noguchi, K., Ishiguro, K., Imahori, K. and Takashima, A.
    Characterization of tau phosphorylation in glycogen synthase kinase-3β and cyclin dependent kinase-5 activator (p23) transfected cells.
    Biochim. Biophys. Acta 1380: 177-182 (1998). [PMID: 9565682]
  4. Aoki, M., Iwamoto-Sugai, M., Sugiura, I., Sasaki, C., Hasegawa, T., Okumura, C., Sugio, S., Kohno, T. and Matsuzaki, T.
    Expression, purification and crystallization of human tau-protein kinase I/glycogen synthase kinase-3β.
    Acta Crystallogr. D Biol. Crystallogr. 56: 1464-1465 (2000). [PMID: 11053853]

[EC 2.7.11.26 created 1990 as EC 2.7.1.135, transferred 2005 to EC 2.7.11.26]