spacer
spacer

PDBsum entry 2p3u
Go to PDB code: 
protein ligands metals Protein-protein interface(s) links
Blood clotting PDB id
2p3u

 

 

 

 

Loading ...

 
JSmol PyMol  
Contents
Protein chains
51 a.a. *
233 a.a. *
Ligands
663
Metals
_CA ×2
Waters ×267
* Residue conservation analysis
PDB id:
2p3u
Name: Blood clotting
Title: Crystal structure of human factor xa complexed with 3-chloro-n-(4- chloro-2-{[(5-chloropyridin-2-yl)amino]carbonyl}-6-methoxyphenyl)-4- [(1-methyl-1h-imidazol-2-yl)methyl]thiophene-2-carboxamide {pfizer 320663}
Structure: Coagulation factor x. Chain: a. Fragment: egf-like 2 domain. Synonym: stuart factor, stuart-prower factor. Coagulation factor x. Chain: b. Fragment: catalytic domain. Synonym: stuart factor, stuart-prower factor. Ec: 3.4.21.6
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: extracted from blood. Organism_taxid: 9606
Resolution:
1.62Å     R-factor:   0.192     R-free:   0.210
Authors: M.Adler,M.Whitlow
Date:
09-Mar-07     Release date:   11-Sep-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00742  (FA10_HUMAN) -  Coagulation factor X from Homo sapiens
Seq:
Struc: 		488 a.a.
51 a.a.
Protein chain
Pfam   ArchSchema ?
P00742  (FA10_HUMAN) -  Coagulation factor X from Homo sapiens
Seq:
Struc: 		488 a.a.
233 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B: E.C.3.4.21.6  - coagulation factor Xa.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Preferential cleavage: Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.

 

spacer
spacer