EC 184.108.40.206 - Coagulation factor Xa
IntEnz Enzyme Nomenclature
activated blood-coagulation factor X
activated factor X
- Selective cleavage of Arg┼Thr and then Arg┼Ile bonds in prothrombin to form thrombin.
A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids. Scutelarin (EC 220.127.116.11) has similar specificity, but does not require factor Va.
Links to other databases
Bovine factor X (Stuart factor).Methods Enzymol. 45: 89-95 (1976). [PMID: 1012041]
The activation of bovine coagulation factor X.Methods Enzymol. 45: 95-107 (1976). [PMID: 1012042]
The role of serine proteases in the blood coagulation cascade.Adv. Enzymol. 48: 277-318 (1979). [PMID: 367103]
Blood coagulation.Annu. Rev. Biochem. 49: 765-811 (1980). [PMID: 6996572]
Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as β-hydroxyaspartic acid.Biochemistry 22: 2875-2884 (1983). [PMID: 6871167]
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.Biochemistry 23: 644-650 (1984). [PMID: 6370301]
[EC 18.104.22.168 created 1972, modified 2010]