EC 3.4.21.6 - Coagulation factor Xa

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IntEnz Enzyme Nomenclature
EC 3.4.21.6

Names

Accepted name:
coagulation factor Xa
Other names:
activated Stuart-Prower factor
activated blood-coagulation factor X
activated factor X
autoprothrombin C
factor Xa
plasma thromboplastin
prothrombase
prothrombinase
thrombokinase
thromboplastin
Stuart factor
Systematic name:
-

Reaction

Comments:

A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids. Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003804
CAS Registry Number: 9002-05-5
UniProtKB/Swiss-Prot: (21) [show] [UniProt]

References

  1. Fujikawa, K. and Davie, E.W.
    Bovine factor X (Stuart factor).
    Methods Enzymol. 45: 89-95 (1976). [PMID: 1012041]
  2. Jesty, J. and Nemerson, Y.
    The activation of bovine coagulation factor X.
    Methods Enzymol. 45: 95-107 (1976). [PMID: 1012042]
  3. Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W.
    The role of serine proteases in the blood coagulation cascade.
    Adv. Enzymol. 48: 277-318 (1979). [PMID: 367103]
  4. Jackson, C.M. and Nemerson, Y.
    Blood coagulation.
    Annu. Rev. Biochem. 49: 765-811 (1980). [PMID: 6996572]
  5. McMullen, B.A., Fujikawa, K., Kisiel, W., Sasagawa, T., Howald, W.N., Kwa, E.Y. and Weinstein, B.
    Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as β-hydroxyaspartic acid.
    Biochemistry 22: 2875-2884 (1983). [PMID: 6871167]
  6. Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C.
    Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
    Biochemistry 23: 644-650 (1984). [PMID: 6370301]

[EC 3.4.21.6 created 1972, modified 2010]