_EC 3.4.21.6 Coagulation factor Xa. 134 PDB entries  
EC 3.-.-.- Hydrolases. [21,057 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,846 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,535 PDB entries]
EC 3.4.21.6 Coagulation factor Xa. [134 PDB entries]    
1apo

Reaction: Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Other name(s): Prothrombase. Prothrombinase. Stuart factor. Thrombokinase.
Comments: A blood coagulation factor formed from the proenzyme factor x by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide Rkr and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids. Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 134 PDB entries in enzyme class E.C.3.4.21.6

  PDB code Protein
1apo
Three-dimensional structure of the apo form of the n- terminal egf-like module of blood coagulation factor x as determined by nmr spectroscopy and simulated folding
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (42 residues) CATH domain: 2.10.25.10
1c5m
Structural basis for selectivity of a small molecule, s1- binding, sub-micromolar inhibitor of urokinase type plasminogen activator
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: D, F (241 residues) CATH domains: 2.40.10.10 2.40.10.10
1ccf
How an epidermal growth factor (egf)-like domain binds calcium-high resolution nmr structure of the calcium form of the nh2-terminal egf-like domain in coagulation factor x
Source: Bos taurus. Organism_taxid: 9913
Chain: A (42 residues) CATH domain: 2.10.25.10
1ezq
Crystal structure of human coagulation factor xa complexed with rpr128515
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
1f0r
Crystal structure of human coagulation factor xa complexed with rpr208815
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
1f0s
Crystal structure of human coagulation factor xa complexed with rpr208707
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
1fax
Coagulation factor xa inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Tissue: blood
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1fjs
Crystal structure of the inhibitor zk-807834 (ci-1031) compl factor xa
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: extracted from blood. Other_details: extracted from blood
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
1g2l
Factor xa inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: blood serum. Other_details: blood serum
Chains: A, B (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1g2m
Factor xa inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: blood serum. Other_details: blood serum
Chains: A, B (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1hcg
Structure of human des(1-45) factor xa at 2.2 angstroms resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (236 residues) CATH domains: 2.40.10.10 2.40.10.10
1iod
Crystal structure of the complex between the coagulation factor x binding protein from snake venom and the gla domain of factor x
Source: Deinagkistrodon acutus. Chinese moccasin. Organism_taxid: 36307. Bos taurus. Cattle. Organism_taxid: 9913
Chain: G (44 residues) CATH domain: 4.10.740.10
1ioe
Human coagulation factor xa in complex with m55532
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1iqe
Human coagulation factor xa in complex with m55590
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1iqf
Human coagulation factor xa in complex with m55165
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1iqg
Human coagulation factor xa in complex with m55159
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1iqh
Human coagulation factor xa in complex with m55143
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1iqi
Human coagulation factor xa in complex with m55125
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1iqj
Human coagulation factor xa in complex with m55124
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1iqk
Human coagulation factor xa in complex with m55113
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1iql
Human coagulation factor xa in complex with m54476
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1iqm
Human coagulation factor xa in complex with m54471
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1iqn
Human coagulation factor xa in complex with m55192
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1kig
Bovine factor xa
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: blood. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932. Ornithodoros moubata. Organism_taxid: 6938. Expression_system_taxid: 4932
Chains: H, L (241 residues) CATH domains: 2.40.10.10 2.40.10.10
1ksn
Crystal structure of human coagulation factor xa complexed with fxv673
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
1kye
Factor xa in complex with (r)-2-(3-adamantan-1-yl-ureido)-3- (3-carbamimidoyl-phenyl)-n-phenethyl-propionamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
1lpg
Crystal structure of fxa in complex with 79.
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (53 residues) CATH domain: 2.10.25.10
1lpk
Crystal structure of fxa in complex with 125.
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (53 residues) CATH domain: 2.10.25.10
1lpz
Crystal structure of fxa in complex with 41.
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (53 residues) CATH domain: 2.10.25.10
1lqd
Crystal structure of fxa in complex with 45.
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (53 residues) CATH domain: 2.10.25.10
1mq5
Crystal structure of 3-chloro-n-[4-chloro-2-[[(4-chloropheny amino]carbonyl]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-2 thiophenecarboxamide complexed with human factor xa
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: extracted from blood. Other_details: extracted from blood
Chains: A, L (233 residues) CATH domains: 2.40.10.10 2.40.10.10
1mq6
Crystal structure of 3-chloro-n-[4-chloro-2-[[(5-chloro-2-py amino]carbonyl]-6-methoxyphenyl]-4-[[(4,5-dihydro-2-oxazoly methylamino]methyl]-2-thiophenecarboxamide complexed with h factor xa
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: extracted from blood. Other_details: extracted from blood
Chains: A, L (233 residues) CATH domains: 2.40.10.10 2.40.10.10
1msx
Human factor xa complexed with 2-[3-(15n-amino-15n-imino- 13c-methyl)phenoxy]-6-[3-(15n-amino-13c-methyl)phenoxy]-3, 5-difluoro-4-methylpyridine (zk-806299), binding model from double redor nmr and md simulations.
Source: Homo sapiens. Human. Secretion: blood. Other_details: purchased from enzyme research labs (south bend, in)
Chain: A (235 residues)
1nfu
Crystal structure of human coagulation factor xa complexed with rpr132747
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: blood. Other_details: blood
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
1nfw
Crystal structure of human coagulation factor xa complexed with rpr209685
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: blood. Other_details: blood
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
1nfx
Crystal structure of human coagulation factor xa complexed with rpr208944
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: blood. Other_details: blood
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
1nfy
Crystal structure of human coagulation factor xa complexed with rpr200095
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: blood. Other_details: blood
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
1nl8
Theoretical model of the tissue factor/factor viia/factor xa complex
Source: Homo sapiens. Human. Human
Chains: L, F (139 residues)
1p0s
Crystal structure of blood coagulation factor xa in complex ecotin m84r
Source: Homo sapiens. Human. Organism_taxid: 9606. Escherichia coli. Organism_taxid: 562. Gene: eco or eti or b2209. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: L, H (99 residues) CATH domains: 4.10.740.10 2.10.25.10
1v3x
Factor xa in complex with the inhibitor 1-[6-methyl-4,5,6,7- tetrahydrothiazolo(5,4-c)pyridin-2-yl] carbonyl-2- carbamoyl-4-(6-chloronaphth-2-ylsulphonyl)piperazine
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product
Chains: A, B (233 residues) CATH domains: 2.40.10.10 2.40.10.10
1whe
Coagulation factor, nmr, 20 structures
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (86 residues) CATH domains: 4.10.740.10 2.10.25.10
1whf
Coagulation factor, nmr, 15 structures
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (86 residues) CATH domains: 4.10.740.10 2.10.25.10
1wu1
Factor xa in complex with the inhibitor 4-[(5-chloroindol-2- sulfonyl]-2-(2-methylpropyl)-1-[[5-(pyridin-4-yl) pyrimidin yl]carbonyl]piperazine
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product
Chains: A, B (233 residues) CATH domains: 2.40.10.10 2.40.10.10
1xka
Factor xa complexed with a synthetic inhibitor fx-2212a,(2s) amidino-3-biphenylyl)-5-(4-pyridylamino)pentanoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Tissue: blood
Chains: L, C (91 residues) CATH domains: 2.10.25.10 2.10.25.10
1xkb
Factor xa complexed with a synthetic inhibitor fx-2212a,(2s) amidino-3-biphenylyl)-5-(4-pyridylamino)pentanoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Tissue: blood
Chains: A, C, B, D (91 residues) CATH domains: 2.10.25.10 2.10.25.10
1z6e
Factor xa in complex with the inhibitor 1-(3'-amino-1,2-benz 5'-yl)-n-(4-(2'-((dimethylamino)methyl)-1h-imidazol-1-yl)-2 fluorophenyl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxamide (razaxaban; dpc906; bms-561389)
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Tissue: blood
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2bmg
Crystal structure of factor xa in complex with 50
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Tissue: blood
Chains: A, B (53 residues) CATH domain: 2.10.25.10
2boh
Crystal structure of factor xa in complex with compound "1"
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Tissue: blood
Chains: A, B (54 residues) CATH domain: 2.10.25.10
2bok
Factor xa - cation
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (223 residues) CATH domains: 2.40.10.10 2.40.10.10
2bq6
Crystal structure of factor xa in complex with 21
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Tissue: blood
Chains: A, B (52 residues) CATH domain: 2.10.25.10
2bq7
Crystal structure of factor xa in complex with 43
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Tissue: blood
Chains: A, B (52 residues) CATH domain: 2.10.25.10
2bqw
Crystal structure of factor xa in complex with compound 45
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Tissue: blood
Chains: A, B (52 residues) CATH domain: 2.10.25.10
2cji
Crystal structure of a human factor xa inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2d1j
Factor xa in complex with the inhibitor 2-[[4-[(5- chloroindol-2-yl)sulfonyl]piperazin-1-yl] carbonyl]thieno[3,2-b]pyridine n-oxide
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product
Chains: A, B (233 residues) CATH domains: 2.40.10.10 2.40.10.10
2ei6
Factor xa in complex with the inhibitor (-)-cis-n1-[(5- chloroindol-2-yl)carbonyl]-n2-[(5-methyl-4,5,6,7- tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2- cyclohexanediamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product
Chains: A, B (233 residues) CATH domains: 2.40.10.10 2.40.10.10
2ei7
Factor xa in complex with the inhibitor trans-n1-[(5- chloroindol-2-yl)carbonyl]-n2-[(5-methyl-4,5,6,7- tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2- cyclohexanediamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product
Chains: A, B (233 residues) CATH domains: 2.40.10.10 2.40.10.10
2ei8
Factor xa in complex with the inhibitor (1s,2r,4s)-n1-[(5- chloroindol-2-yl)carbonyl]-4-(n,n-dimethylcarbamoyl)-n2- [(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl) carbonyl]-1,2-cyclohexanediamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product
Chains: A, B (233 residues) CATH domains: 2.40.10.10 2.40.10.10
2fzz
Factor xa in complex with the inhibitor 1-(3-amino-1,2- benzisoxazol-5-yl)-6-(2'-(((3r)-3-hydroxy-1-pyrrolidinyl) methyl)-4-biphenylyl)-3-(trifluoromethyl)-1,4,5,6- tetrahydro-7h-pyrazolo[3,4-c]pyridin-7-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2g00
Factor xa in complex with the inhibitor 3-(6-(2'- ((dimethylamino)methyl)-4-biphenylyl)-7-oxo-3- (trifluoromethyl)-4,5,6,7-tetrahydro-1h-pyrazolo[3,4- c]pyridin-1-yl)benzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2gd4
Crystal structure of the antithrombin-s195a factor xa-pentas complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f10. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: serpinc1, at3
Chains: L, H, A, B (54 residues) CATH domain: 2.10.25.10
2h9e
Crystal structure of fxa/selectide/napc2 ternary complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Ancylostoma caninum. Dog hookworm. Organism_taxid: 29170. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes.
Chains: H, L (233 residues) CATH domains: 2.40.10.10 2.40.10.10
2j2u
Crystal structure of a human factor xa inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzym research labs. Isolated from human blood. Isolated from human blood
Chains: A, B (229 residues) CATH domains: 2.40.10.10 2.40.10.10
2j34
Crystal structure of a human factor xa inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzyme research labs isolated from human blood. Isolated from human blood
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2j38
Crystal structure of a human factor xa inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzyme research labs isolated from human blood. Isolated from human blood
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2j4i
Crystal structure of a human factor xa inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzyme research labs. Isolated from human blood. Isolated from human blood
Chains: A, B (232 residues) CATH domains: 2.40.10.10 2.40.10.10
2j94
Crystal structure of a human factor xa inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzyme research labs. Isolated from human blood. Isolated from human blood
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2j95
Crystal structure of a human factor xa inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzyme research labs. Isolated from human blood. Isolated from human blood
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2jkh
Factor xa - cation inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2p16
Factor xa in complex with the inhibitor apixaban (bms- 562247) aka 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1- piperidinyl)phenyl)-4,5,6,7-tetrahydro-1h-pyrazolo[3, 4- c]pyridine-3-carboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2p3f
Crystal structure of the factor xa/nap5 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Ancylostoma caninum. Dog hookworm. Organism_taxid: 29170
Chains: H, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
2p3t
Crystal structure of human factor xa complexed with 3- chloro-4-(2-methylamino-imidazol-1-ylmethyl)-thiophene-2- carboxylic acid [4-chloro-2-(5-chloro-pyridin-2- ylcarbamoyl)-6-methoxy-phenyl]-amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: extracted from blood. Other_details: extracted from blood
Chains: A, B (52 residues) CATH domain: 2.10.25.10
2p3u
Crystal structure of human factor xa complexed with 3- chloro-n-(4-chloro-2-{[(5-chloropyridin-2-yl) amino]carbonyl}-6-methoxyphenyl)-4-[(1-methyl-1h-imidazol- 2-yl)methyl]thiophene-2-carboxamide {pfizer 320663}
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: extracted from blood. Organism_taxid: 9606
Chains: A, B (51 residues) CATH domain: 2.10.25.10
2p93
Factor xa in complex with the inhibitor 5-chloro-n-(2-(4-(2- oxopyridin-1(2h)-yl)benzamido)ethyl)thiophene-2-carboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product. Organism_taxid: 9606
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2p94
Factor xa in complex with the inhibitor 3-chloro-n-((1r,2s)- 2-(4-(2-oxopyridin-1(2h)-yl)benzamido)cyclohexyl)-1h- indole-6-carboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2p95
Factor xa in complex with the inhibitor 5-chloro-n-((1r,2s)- 2-(4-(2-oxopyridin-1(2h)-yl)benzamido) cyclopentyl) thiophene-2-carboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product. Organism_taxid: 9606
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2phb
An orally efficacious factor xa inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f10. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2pr3
Factor xa inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f10. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2q1j
The discovery of glycine and related amino acid-based factor xa inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2ra0
X-ray structure of fxa in complex with 7-fluoroindazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f10. Other_details: mammalian. Other_details: mammalian
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2uwl
Selective and dual action orally active inhibitors of thrombin and factor xa
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzyme research labs. Isolated from human blood. Isolated from human blood
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2uwo
Selective and dual action orally active inhibitors of thrombin and factor xa
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzyme research labs. Isolated from human blood. Isolated from human blood
Chains: A, B (232 residues) CATH domains: 2.40.10.10 2.40.10.10
2uwp
Factor xa inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzyme research labs. Isolated from human blood. Isolated from human blood
Chains: A, B (235 residues) CATH domains: 2.40.10.10 2.40.10.10
2vh0
Structure and property based design of factor xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzyme research labs. Isolated from human blood. Isolated from human blood
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2vh6
Structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with biaryl p4 motifs
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzyme research labs. Isolated from human blood. Isolated from human blood
Chains: A, B (232 residues) CATH domains: 2.40.10.10 2.40.10.10
2vvc
Aminopyrrolidine factor xa inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, K, L (233 residues) CATH domains: 2.40.10.10 2.40.10.10
2vvu
Aminopyrrolidine factor xa inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2vvv
Aminopyrrolidine-related triazole factor xa inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2vwl
Aminopyrrolidine factor xa inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
2vwm
Aminopyrrolidine factor xa inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, K, L (232 residues) CATH domains: 2.40.10.10 2.40.10.10
2vwn
Aminopyrrolidine factor xa inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
2vwo
Aminopyrrolidine factor xa inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
2w26
Factor xa in complex with bay59-7939
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2w3i
Crystal structure of fxa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2w3k
Crystal structure of fxa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2wyg
Structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with monoaryl p4 motifs
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Other_details: purchased from enzyme research labs, isolate human blood. Human blood
Chains: A, B (228 residues) CATH domains: 2.40.10.10 2.40.10.10
2wyj
Structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with monoaryl p4 motifs
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Other_details: purchased from enzyme research labs, isolate human blood. Human blood
Chains: A, B (230 residues) CATH domains: 2.40.10.10 2.40.10.10
2xbv
Factor xa in complex with a pyrrolidine-3,4-dicarboxylic aci inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
2xbw
Factor xa in complex with a pyrrolidine-3,4-dicarboxylic aci inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
2xbx
Factor xa in complex with a pyrrolidine-3,4-dicarboxylic aci inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
2xby
Factor xa in complex with a pyrrolidine-3,4-dicarboxylic aci inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
2xc0
Factor xa in complex with a pyrrolidine-3,4-dicarboxylic aci inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
2xc4
Factor xa in complex with a pyrrolidine-3,4-dicarboxylic aci inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2xc5
Factor xa in complex with a pyrrolidine-3,4-dicarboxylic aci inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
2y5f
Factor xa - cation inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2y5g
Factor xa - cation inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2y5h
Factor xa - cation inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
2y7x
The discovery of potent and long-acting oral factor xa inhib with tetrahydroisoquinoline and benzazepine p4 motifs
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzyme research labs. Isolate human blood. Human blood
Chains: A, B (235 residues) CATH domains: 2.40.10.10 2.40.10.10
2y7z
Structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine p4
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzyme research labs. Isolate human blood. Human blood
Chains: A, B (235 residues) CATH domains: 2.40.10.10 2.40.10.10
2y80
Structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine p4 motifs
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzyme research labs. Isolate human blood. Human blood
Chains: A, B (235 residues) CATH domains: 2.40.10.10 2.40.10.10
2y81
Structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine p4
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzyme research labs. Isolate human blood. Human blood
Chains: A, B (233 residues) CATH domains: 2.40.10.10 2.40.10.10
2y82
Structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine p4 motifs
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from enzyme research labs. Isolate human blood. Human blood
Chains: A, B (235 residues) CATH domains: 2.40.10.10 2.40.10.10
3cen
Factor xa in complex with the inhibitor n-(2-(((5-chloro-2- pyridinyl) amino)sulfonyl)phenyl)-4-(2-oxo-1(2h)- pyridinyl)benzamide
Source: Homo sapiens. Human. Other_details: proteolytic cleavage product. Other_details: proteolytic cleavage product
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
3cs7
Factor xa in complex with the inhibitor 1-(4-methoxyphenyl)- 6-(4-(1-(pyrrolidin-1-ylmethyl)cyclopropyl)phenyl)-3- (trifluoromethyl)-5,6-dihydro-1h-pyrazolo[3,4-c]pyridin- 7(4h)-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product. Other_details: proteolytic cleavage product
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
3ens
Crystal structure of human fxa in complex with methyl (2z)-3 chloro-1h-indol-7-yl)amino]-2-cyano-3-{[(3s)-2-oxo-1-(2-oxo pyrrolidin-1-ylethyl)azepan-3-yl]amino}acrylate
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: blood. Other_details: blood
Chains: A, B, C, D (84 residues) CATH domains: 2.10.25.10 2.10.25.10
3ffg
Factor xa in complex with the inhibitor (r)-6-(2'-((3- hydroxypyrrolidin-1-yl)methyl)biphenyl-4-yl)-1-(3-(5-oxo-4, 5-dihydro-1h-1,2,4-triazol-3-yl)phenyl)-3- (trifluoromethyl)-5,6-dihydro-1h-pyrazolo[3,4-c]pyridin- 7(4h)-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
3hpt
Crystal structure of human fxa in complex with (s)-2-cyano-1 methylbenzofuran-5-yl)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl azepan-3-yl)guanidine
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Tissue: blood
Chains: A, B, C, D (84 residues) CATH domains: 2.10.25.10 2.10.25.10
3iit
Factor xa in complex with a cis-1,2-diaminocyclohexane deriv
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product
Chains: A, B (233 residues) CATH domains: 2.40.10.10 2.40.10.10
3k9x
X-ray crystal structure of human fxa in complex with (s)-n-( methylbenzofuran-5-ylamino)(2-oxo-1-(2-oxo-2- (pyrrolidin-1 ethyl)azepan-3- ylamino)methylene)nicotinamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Secretion: blood. Secretion: blood
Chains: A, B, C, D (86 residues) CATH domains: 2.10.25.10 2.10.25.10
3kl6
Discovery of tetrahydropyrimidin-2(1h)-one derivative tak-44 potent, selective and orally active factor xa inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f10. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_taxid: 7108
Chains: A, B (232 residues) CATH domains: 2.40.10.10 2.40.10.10
3kqb
Factor xa in complex with the inhibitor n-(3-fluoro-2'- (methylsulfonyl)biphenyl-4-yl)-1-(3-(5-oxo-4,5-dihydro-1h- triazol-3-yl)phenyl)-3-(trifluoromethyl)-1h- pyrazole-5-car
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product. Other_details: proteolytic cleavage product
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
3kqc
Factor xa in complex with the inhibitor 6-(2'- (methylsulfon biphenyl-4-yl)-1-(3-(5-oxo-4,5-dihydro-1h- 1,2,4-triazol-3- phenyl)-3-(trifluoromethyl)-5,6- dihydro-1h-pyrazolo[3,4-c] 7(4h)-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product. Other_details: proteolytic cleavage product
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
3kqd
Factor xa in complex with the inhibitor 1-(3-(5-oxo-4,5- dih 2,4-triazol-3-yl)phenyl)-6-(2'-(pyrrolidin-1- ylmethyl)biph yl)-3-(trifluoromethyl)-5,6-dihydro- 1h-pyrazolo[3,4-c]pyri one
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product. Other_details: proteolytic cleavage product
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
3kqe
Factor xa in complex with the inhibitor 3-methyl-1-(3-(5- ox dihydro-1h-1,2,4-triazol-3-yl)phenyl)-6-(2'- (pyrrolidin-1- biphenyl-4-yl)-5,6-dihydro-1h- pyrazolo[3,4-c]pyridin-7(4h)
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product. Other_details: proteolytic cleavage product
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
3liw
Factor xa in complex with (r)-2-(1-adamantylcarbamoylamino)- 3-(3-carbamidoyl-phenyl)-n-phenethyl-propionic acid amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (234 residues) CATH domains: 2.40.10.10 2.40.10.10
3m36
Factor xa in complex with the inhibitor 1-[3-(aminomethyl) phenyl]-n-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3- (trifluoromethyl)-1h-pyrazole-5-carboxamide (dpc423)
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
3m37
Factor xa in complex with the inhibitor 1-[2-(aminomethyl) phenyl]-n-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)-3- (trifluoromethyl)-1h-pyrazole-5-carboxamide (dpc602)
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, L (234 residues) CATH domains: 2.40.10.10 2.40.10.10
3q3k
Factor xa in complex with a phenylenediamine derivative
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (233 residues) CATH domains: 2.40.10.10 2.40.10.10
3sw2
X-ray crystal structure of human fxa in complex with 6-chlor 2-oxo-1-(2-oxo-2-((5s)-8-oxo-5,6-dihydro-1h-1,5-methanopyri a][1,5]diazocin-3(2h,4h,8h)-yl)ethyl)piperidin-3-yl)naphtha sulfonamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Tissue: blood
Chains: A, B (56 residues) CATH domain: 2.10.25.10
3tk5
Factor xa in complex with d102-4380
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (233 residues) CATH domains: 2.40.10.10 2.40.10.10
3tk6
Factor xa in complex with d46-5241
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chains: A, B (233 residues) CATH domains: 2.40.10.10 2.40.10.10
4a7i
Factor xa in complex with a potent 2-amino-ethane sulfonamide inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Tissue: blood
Chains: A, B (53 residues) CATH domain: 2.10.25.10
4bti
Factor xa in complex with the dual thrombin-fxa inhibitor 58
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Other_details: isolated from human serum. Other_details: isolated from human serum
Chains: A, B, E, F (54 residues) CATH domain: 2.10.25.10
4btt
Factor xa in complex with the dual thrombin-fxa inhibitor 31
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: serum. Tissue: serum
Chains: A, B, E, F (51 residues) CATH domain: 2.10.25.10
4btu
Factor xa in complex with the dual thrombin-fxa inhibitor 57
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: serum. Tissue: serum
Chains: A, B, E, F (54 residues) CATH domain: 2.10.25.10