PDBsum entry 2lzp

Viral protein

PDB id: 2lzp

Contents

Protein chain

31 a.a.

PDB id:

2lzp

Name:

Viral protein

Title:

Structure of ns2(2-32) gbvb protein

Structure:

Ns2 peptide. Chain: a. Engineered: yes

Source:

Synthetic: yes. Hepatitis gb virus b. Gbv-b. Organism_taxid: 39113

NMR struc:

39 models

Authors:

R.Montserret,F.Penin,A.Martin

Key ref:

C.Boukadida et al. (2014). NS2 proteins of GB virus B and hepatitis C virus share common protease activities and membrane topologies. J Virol, 88, 7426-7444. PubMed id: 24741107 DOI: 10.1128/JVI.00656-14

Date:

08-Oct-12 Release date: 09-Apr-14

Protein chain

Q69422  (POLG_GBVB) -  Genome polyprotein from Hepatitis GB virus B

Seq: 2864 a.a.

Struc: 31 a.a.

Enzyme reactions

• Enzyme class 1: E.C.2.7.7.48 - RNA-directed Rna polymerase.
• Reaction: RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
• Enzyme class 2: E.C.3.4.21.98 - hepacivirin.
• Reaction: Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
• Enzyme class 3: E.C.3.4.22.- - ?????
• Enzyme class 4: E.C.3.6.1.15 - nucleoside-triphosphate phosphatase.
• Reaction: a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H⁺
• Enzyme class 5: E.C.3.6.4.13 - Rna helicase.
• Reaction: ATP + H2O = ADP + phosphate + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

DOI no: 10.1128/JVI.00656-14

J Virol 88:7426-7444 (2014)

PubMed id: 24741107

NS2 proteins of GB virus B and hepatitis C virus share common protease activities and membrane topologies.

C.Boukadida, C.Marnata, R.Montserret, L.Cohen, B.Blumen, J.Gouttenoire, D.Moradpour, F.Penin, A.Martin.

ABSTRACT

No abstract given.