EC 3.4.21.98 - Hepacivirin

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IntEnz Enzyme Nomenclature
EC 3.4.21.98

Names

Accepted name:
hepacivirin
Other names:
Cpro-2
NS3-4A serine proteinase complex
hepatitis C virus NS3 serine proteinase
Systematic name:

Reaction

Comments:

Encoded by the genome of the viruses of the hepatitis C group, and contributes to the maturation of the precursor polyproteins. The enzyme is greatly activated by binding of the 54-residue NS4A 'cofactor' protein also derived from the viral polyprotein. Type example of peptidase family S29. The crystallographic structure shows a chymotrypsin-like fold.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 149885-80-3
UniProtKB/Swiss-Prot: (33) [show] [UniProt]

References

  1. Kim, J.L., Morgenstern, K.A., Lin, C., Fox, T., Dwyer, M.D., Landro, J.A., Chambers, S.P., Markland, W., Lepre, C.A., O'Malley, E.T., Harbeson, S.L., Rice, C.M., Murcko, M.A., Caron, P.R. and Thomson, J.A.
    Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide.
    Cell 87: 343-355 (1996). [PMID: 8861917]
  2. Rice, C.M.
    Hepatitis C virus polyprotein peptidase.
    In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.) Handbook of Proteolytic Enzymes, Academic Press, London, 1998, 272-277

[EC 3.4.21.98 created 2000]