_EC 3.4.21.98 Hepacivirin. 237 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,852 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,536 PDB entries]
EC 3.4.21.98 Hepacivirin. [237 PDB entries]    
1a1q

Reaction: Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
Other name(s): Cpro-2. Hepatitis C virus NS3 serine proteinase.
Comments: Encoded by the genome of the viruses of the hepatitis C group, and contributes to the maturation of the precursor polyproteins. The enzyme is greatly activated by binding of the 54-residue NS4A 'cofactor' protein also derived from the viral polyprotein. Belongs to peptidase family S29.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 237 PDB entries in enzyme class E.C.3.4.21.98

  PDB code Protein
1a1q
Hepatitis c virus ns3 proteinase
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: type 1b. Variant: bk isolate. Gene: cdna. Expressed in: escherichia coli. Expression_system_taxid: 562. Isolated from pat. Other_details: expressed as soluble protein
Chains: A, B, C (183 residues)
1a1r
Hcv ns3 protease domain:ns4a peptide complex
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: h. Gene: ns3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (152 residues) CATH domains: 2.40.10.120 2.40.10.10
1a1v
Hepatitis c virus ns3 helicase domain complexed with single stranded sdna
Source: Hepatitis c virus (isolate h). Organism_taxid: 11108. Strain: h. Gene: ns3. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic deoxyoligonucleotide
Chain: A (432 residues) CATH domains: 3.40.50.300 3.40.50.300 1.10.820.10
1bt7
The solution nmr structure of the n-terminal protease domain of the hepatitis c virus (hcv) ns3-protein, from bk strain, 20 structures
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: bk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (165 residues) CATH domains: 2.40.10.120 2.40.10.10
1c2p
Hepatitis c virus ns5b RNA-dependent RNA polymerase
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (558 residues) CATH domains: Unassigned Unassigned 3.30.70.270
1csj
Crystal structure of the RNA-dependent RNA polymerase of hep virus
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (531 residues) CATH domains: Unassigned Unassigned 3.30.70.270
1cu1
Crystal structure of an enzyme complex from hepatitis c virus
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (645 residues) CATH domains: 2.40.10.120 2.40.10.10 3.40.50.300 3.40.50.300 1.10.820.10
1cwx
Solution structure of the hepatitis c virus n-terminal capsid protein 2-45 [c-hcv(2-45)]
Source: Synthetic: yes. Other_details: the protein was chemically synthesized. This sequence occurs naturally in hepatitis c virus (genotype 1a isolate h77)..
Chain: A (44 residues) CATH domain: 4.10.710.10
1dxp
Inhibition of the hepatitis c virus ns3/4a protease. The cry structures of two protease-inhibitor complexes (apo structu
Source: Hepatitis c virus (isolate taiwan). Organism_taxid: 31645. Gene: hcv. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: cdna of hepatitis c virus. Synthetic: yes. Hepatitis c virus. Organism_taxid: 31645
Chains: A, B, C, D (175 residues) CATH domains: 2.40.10.120 2.40.10.10
1dy8
Inhibition of the hepatitis c virus ns3/4a protease. The cry structures of two protease-inhibitor complexes (inhibitor i
Source: Hepatitis c virus (isolate taiwan). Organism_taxid: 31645. Gene: hcv. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: cdna of hepatitis c virus. Other_details: cdna of hepatitis c virus
Chains: A, B, C, D (175 residues) CATH domains: 2.40.10.120 2.40.10.10
1dy9
Inhibition of the hepatitis c virus ns3/4a protease. The cry structures of two protease-inhibitor complexes (inhibitor i
Source: Hepatitis c virus (isolate 1). Organism_taxid: 31645. Strain: isolate taiwan. Gene: hcv. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: cdna of hepatitis c virus. Synthetic: yes. Hepatitis c virus.
Chains: A, B, C, D (175 residues) CATH domains: 2.40.10.120 2.40.10.10
1gx5
Hepatitis c virus RNA polymerase in complex with gtp and manganese
Source: Hepatitis c virus (isolate bk). Hcv. Strain: bk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (530 residues) CATH domains: Unassigned Unassigned 3.30.70.270
1gx6
Hepatitis c virus RNA polymerase in complex with utp and manganese
Source: Hepatitis c virus (isolate bk). Hcv. Strain: bk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (531 residues) CATH domains: Unassigned Unassigned 3.30.70.270
1hei
Structure of the hepatitis c virus RNA helicase domain
Source: Hepatitis c virus (isolate 1). Organism_taxid: 11104. Strain: h. Variant: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (443 residues) CATH domains: 3.40.50.300 3.40.50.300 1.10.820.10
1jr6
Solution structure of an engineered arginine-rich subdomain 2 of the hepatitis c virus ns3 RNA helicase
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (138 residues) CATH domain: 3.40.50.300
1jxp
Bk strain hepatitis c virus (hcv) ns3-ns4a
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Strain: bk strain isolate. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C, B, D (177 residues) CATH domains: 2.40.10.120 2.40.10.10
1n1l
Crystal structure of hcv ns3 protease domain:ns4a peptide complex with covalently bound inhibitor (gw472467x)
Source: Hepatitis c virus. Organism_taxid: 11103. Gene: h strain. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized. The sequence of the protein is naturally found in hepatitis c virus type 1b.
Chains: A, B (180 residues) CATH domains: 2.40.10.120 2.40.10.10
1n64
Crystal structure analysis of the immunodominant antigenic s hepatitis c virus protein bound to mab 19d9d6
Source: Mus musculus. Mouse. Organism_taxid: 10090. Synthetic: yes. Other_details: sequence from hepatitis c virus core protein
Chain: P (16 residues)
1nb4
Hc-j4 RNA polymerase apo-form
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (566 residues) CATH domains: Unassigned Unassigned
1nb6
Hc-j4 RNA polymerase complexed with utp
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (566 residues) CATH domains: Unassigned Unassigned
1nb7
Hc-j4 RNA polymerase complexed with short RNA template strand
Source: Synthetic: yes. Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (566 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned
1nhu
Hepatitis c virus RNA polymerase in complex with non- nucleoside analogue inhibitor
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Strain: subtype 1b. Variant: type 1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (558 residues) CATH domains: Unassigned Unassigned 3.30.70.270
1nhv
Hepatitis c virus RNA polymerase in complex with non- nucleoside analogue inhibitor
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Strain: subtype 1b. Variant: type 1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (558 residues) CATH domains: Unassigned Unassigned 3.30.70.270
1ns3
Structure of hcv protease (bk strain)
Source: Hepatitis c virus. Organism_taxid: 11105. Strain: isolate bk. Variant: isolate bk. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, C, D (178 residues) CATH domains: 2.40.10.120 2.40.10.10
1onb
Solution structure of an engineered arginine-rich subdomain 2 of the hepatitis c virus ns3 RNA helicase
Source: Hepatitis c virus. Organism_taxid: 11103. Gene: ns3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (138 residues) CATH domain: 3.40.50.300
1os5
Crystal structure of hcv ns5b RNA polymerase complexed with non-competitive inhibitor.
Source: Hepatitis c virus. Organism_taxid: 31647. Strain: subtype 1b. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (563 residues) CATH domains: Unassigned Unassigned 3.30.70.270
1quv
Crystal structure of the RNA directed RNA polymerase of hepatitis c virus
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: 1b (bk). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (553 residues) CATH domains: Unassigned Unassigned 3.30.70.270
1r7c
Nmr structure of the membrane anchor domain (1-31) of the nonstructural protein 5a (ns5a) of hepatitis c virus (minimized average structure, sample in 50% tfe)
Source: Synthetic: yes. Other_details: the peptide was chemically synthesized. The sequence is naturally found in hepatitis c virus.
Chain: A (31 residues)
1r7d
Nmr structure of the membrane anchor domain (1-31) of the nonstructural protein 5a (ns5a) of hepatitis c virus (ensemble of 51 structures, sample in 50% tfe)
Source: Synthetic: yes. Other_details: the peptide was chemically synthesized. The sequence is naturally found in hepatitis c virus.
Chain: A (31 residues)
1r7e
Nmr structure of the membrane anchor domain (1-31) of the nonstructural protein 5a (ns5a) of hepatitis c virus (minimized average structure. Sample in 100mm sds).
Source: Synthetic: yes. Other_details: the peptide was chemically synthesized. The sequence is naturally found in hepatitis c virus.
Chain: A (31 residues)
1r7f
Nmr structure of the membrane anchor domain (1-31) of the nonstructural protein 5a (ns5a) of hepatitis c virus (ensemble of 43 structures. Sample in 100mm sds)
Source: Synthetic: yes. Other_details: the peptide was chemically synthesized. The sequence is naturally found in hepatitis c virus.
Chain: A (31 residues)
1r7g
Nmr structure of the membrane anchor domain (1-31) of the nonstructural protein 5a (ns5a) of hepatitis c virus (minimized average structure, sample in 100mm dpc)
Source: Synthetic: yes. Other_details: the peptide was chemically synthesized. The sequence is naturally found in hepatitis c virus.
Chain: A (31 residues)
1rgq
M9a hcv protease complex with pentapeptide keto-amide inhibi
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized. The of the peptide is naturally found in hepatitis c virus
Chains: A, B (154 residues) CATH domains: 2.40.10.120 2.40.10.10
1w3c
Crystal structure of the hepatitis c virus ns3 protease in complex with a peptidomimetic inhibitor
Source: Hepatitis c virus (isolate 1). Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: expressed under t7 promoter, iptg induced. Synthetic: yes. Hepatitis c virus (isolate 1)
Chains: A, B, C, D (174 residues) CATH domains: 2.40.10.120 2.40.10.10
1xcq
Complex hcv core-fab 19d9d6-protein l mutant (d55a,l57h,y64w group p21
Source: Synthetic: yes. Other_details: this sequence occurs naturally in hcv virus. Mus musculus. House mouse. Organism_taxid: 10090. Finegoldia magna. Organism_taxid: 334413. Strain: atcc 29328. Expressed in: escherichia coli.
Chains: P, Q, S (24 residues)
1xct
Complex hcv core-fab 19d9d6-protein l mutant (d55a, l57h, y6 space group p21212
Source: Synthetic: yes. Other_details: this sequence occurs naturally in hcv virus. Mus musculus. House mouse. Organism_taxid: 10090. Finegoldia magna. Organism_taxid: 334413. Strain: atcc 29328. Expressed in: escherichia coli.
Chains: P, Q (30 residues)
1xf5
Complex hcv core-fab 19d9d6-protein l mutant (h74c, y64w)in group p21212
Source: Synthetic: yes. Other_details: this sequence occurs naturally in hcv. Mus musculus. House mouse. Organism_taxid: 10090. Finegoldia magna. Organism_taxid: 334413. Strain: atcc 29328. Expressed in: escherichia coli.
Chain: P (16 residues)
1yuy
Hepatitis c virus ns5b RNA-dependent RNA polymerase genotype 2a
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (558 residues) CATH domains: Unassigned Unassigned
1yv2
Hepatitis c virus ns5b RNA-dependent RNA polymerase genotype
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (548 residues) CATH domains: Unassigned Unassigned
1yvx
Hepatitis c virus RNA polymerase genotype 2a in complex with non- nucleoside analogue inhibitor
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (548 residues) CATH domains: Unassigned Unassigned
1yvz
Hepatitis c virus RNA polymerase genotype 2a in complex with non- nucleoside analogue inhibitor
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (548 residues) CATH domains: Unassigned Unassigned
1zh1
Structure of the zinc-binding domain of hcv ns5a
Source: Hepatitis c virus. Organism_taxid: 11103. Gene: nonstructural protein 5a. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (163 residues) CATH domains: Unassigned Unassigned
2a4g
Hepatitis c protease ns3-4a serine protease with ketoamide inhibitor sch225724 bound
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized. The sequence of the protein is naturally found in hepatitis c virus type 1b.
Chains: A, C (181 residues) CATH domains: 2.40.10.120 2.40.10.10
2a4r
Hcv ns3 protease domain with a ketoamide inhibitor covalentl
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized. The of the protein is naturally found in hepatitis c virus type
Chains: A, B, C, D (181 residues) CATH domains: 2.40.10.120 2.40.10.10
2awz
Hepatitis c virus ns5b RNA polymerase in complex with a covalent inhibitor (5h)
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2ax0
Hepatitis c virus ns5b RNA polymerase in complex with a covalent inhibitor (5x)
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (554 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2ax1
Hepatitis c virus ns5b RNA polymerase in complex with a covalent inhibitor (5ee)
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (554 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2brk
Crystal structure of hepatitis c virus polymerase in complex with an allosteric inhibitor (compound 1)
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: genotype 1b, strain bk. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: genbank accession number ab016785
Chain: A (512 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2brl
Crystal structure of hepatitis c virus polymerase in complex with an allosteric inhibitor (compound 2)
Source: Hepatitis c virus. Hcv. Organism_taxid: 11103. Strain: genotype 1b, strain bk. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: genbank accession number ab016785
Chain: A (512 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2dxs
Crystal structure of hcv ns5b RNA polymerase complexed with a tetracyclic inhibitor
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: bk. Gene: 1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (517 residues) CATH domains: Unassigned Unassigned
2f55
Two hepatitis c virus ns3 helicase domains complexed with the same strand of DNA
Source: Synthetic: yes. Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (432 residues) CATH domains: 3.40.50.300 3.40.50.300 1.10.820.10
2f9v
Hcv ns3 protease domain with ns4a peptide and a ketoamide inhibitor with p1 and p2 cyclopropylalannines
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: h. Gene: ns3 protease domain ( residues 1027-1207 of the polyprotein).. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: solid-phase peptide synthesis of the ns4a
Chains: A, B, C, D (183 residues) CATH domains: 2.40.10.120 2.40.10.10
2giq
Hepatitis c virus RNA-dependent RNA polymerase ns5b with nni inhibitor
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Strain: genotype 1b. Strain bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2gir
Hepatitis c virus RNA-dependent RNA polymerase ns5b with nni inhibitor
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Strain: genotype 1b, strain bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2gvf
Hcv ns3-4a protease domain complexed with a macrocyclic ketoamide inhibitor, sch419021
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in hepatitis c virus
Chains: A, B, C, D (183 residues) CATH domains: 2.40.10.120 2.40.10.10
2hai
Crystal structure of hcv ns5b RNA polymerase in complex with novel class of dihydropyrone-containing inhibitor.
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: genotype 1b. Gene: ns5b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (562 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2hd0
Structure of the catalytic domain of hepatitis c virus ns2
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (127 residues) CATH domains: Unassigned Unassigned
2hwh
Hcv ns5b allosteric inhibitor complex
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2hwi
Hcv ns5b allosteric inhibitor complex
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2i1r
Novel thiazolones as hcv ns5b polymerase inhibitors: further designs, synthesis, sar and x-ray complex structure
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2jxf
The solution structure of hcv ns4b(40-69)
Source: Synthetic: yes. Other_details: the peptide was synthesized by solid-phase synthesis. Free n and c termini
Chain: A (30 residues)
2k8j
Solution structure of hcv p7 tm2
Source: Synthetic: yes. Other_details: the protein was chemically synthesized. It i naturally found in hepatitis c virus.
Chain: X (29 residues)
2kdr
Solution structure of hcv ns4b(227-254)
Source: Synthetic: yes. Hepatitis c virus. Organism_taxid: 11103. Other_details: the peptide was synthesized by solid-phase synthesis
Chain: X (28 residues)
2knu
Solution structure of the transmembrane proximal region of the hepatis c virus e1 glycoprotein
Source: Synthetic: yes. Hepatitis c virus. Organism_taxid: 11103. Other_details: peptide synthesis
Chain: A (29 residues)
2kwt
Solution structure of ns2 [27-59]
Source: Hepatitis c virus. Hcv. Organism_taxid: 333284
Chain: A (33 residues)
2kwz
Solution structure of ns2 [60-99]
Source: Hepatitis c virus. Hcv. Organism_taxid: 11103
Chain: A (40 residues) CATH domain: Unassigned
2kzq
S34r structure
Source: Synthetic: yes. Hepatitis c virus. Hcv. Organism_taxid: 356411. Other_details: chemical synthesis
Chain: A (36 residues)
2lif
Solution structure of kkgf
Source: Synthetic: yes. Hepatitis c virus jfh-1. Hcv. Organism_taxid: 356411
Chain: A (27 residues)
2lvg
Nmr structure of hcv non-structural protein ab, ns4b(1-40)
Source: Synthetic: yes. Hepatitis c virus jfh-1. Hcv. Organism_taxid: 356411
Chain: A (40 residues) CATH domain: Unassigned
2lzp
Structure of ns2(2-32) gbvb protein
Source: Synthetic: yes. Hepatitis gb virus b. Gbv-b. Organism_taxid: 39113
Chain: A (31 residues)
2lzq
Structure of ns2(32-57) gbvb protein
Source: Synthetic: yes. Hepatitis gb virus b. Gbv-b. Organism_taxid: 39113
Chain: A (26 residues)
2m6x
Structure of the p7 channel of hepatitis c virus, genotype 5
Source: Hepatitis c virus. Hcv. Organism_taxid: 356419. Strain: euh1480. Variant: genotype 5a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (63 residues) CATH domain: Unassigned
2mkb
Structure of ns2(113-137) gbvb protein
Source: Synthetic: yes. Hepatitis gb virus b. Gbv-b. Organism_taxid: 39113
Chain: A (25 residues)
2o5d
Thiazolone-acylsulfonamides as novel hcv ns5b polymerase allosteric inhibitors: convergence of structure-based drug design and x-ray crystallographic study
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2o8m
Crystal structure of the s139a mutant of hepatitis c virus ns3/4a protease
Source: Hepatitis c virus. Organism_taxid: 11103. Gene: hcv. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: C, D (23 residues)
2obq
Discovery of the hcv ns3/4a protease inhibitor sch503034. Ke structure-based optimization
Source: Hepatitis c virus. Organism_taxid: 11103. Gene: hcv. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: B, D (22 residues)
2oin
Crystal structure of hcv ns3-4a r155k muntant
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: h. Gene: ns3. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B, C, D (151 residues) CATH domains: 2.40.10.120 2.40.10.10
2p59
Crystal structure of hepatitis c virus ns3.4a protease
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: hcv-h strain. Gene: ns3 protease domain. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: synthetic peptide
Chains: C, D (16 residues)
2qv1
Crystal structure of hcv ns3-4a v36m mutant
Source: Hepatitis c virus. Strain: h. Gene: ns3. Expressed in: escherichia coli. Synthetic: yes
Chains: C, D (16 residues)
2wcx
Crystal structure of hepatitis c virus ns5b polymerase in complex with thienopyrrole-based finger-loop inhibitors
Source: Hepatitis c virus. Organism_taxid: 11105. Strain: (isolate bk). Variant: genotype 1b. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: genbank accession number ab016785
Chain: A (512 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2who
Crystal structure of hepatitis c virus ns5b polymerase from 1b genotype in complex with a non-nucleoside inhibitor
Source: Hepatitis c virus. Organism_taxid: 11105. Strain: isolate bk. Variant: genotype 1b. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: genbank accession number ab016785
Chains: A, B (531 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2wrm
Identification of novel allosteric inhibitors of hepatitis c virus ns5b polymerase thumb domain (site ii) by structure-based design
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: isolate bk. Variant: genotype 1b. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: genbank accession number ab016785
Chain: A (531 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2xhu
Hcv-j4 ns5b polymerase orthorhombic crystal form
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: j4. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (562 residues) CATH domains: Unassigned Unassigned
2xhv
Hcv-j4 ns5b polymerase point mutant orthorhombic crystal form
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: j4. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (563 residues) CATH domains: Unassigned Unassigned
2xhw
Hcv-j4 ns5b polymerase trigonal crystal form
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: j4. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (560 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned
2xi2
Hcv-h77 ns5b apo polymerase
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: h77. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (562 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2xi3
Hcv-h77 ns5b polymerase complexed with gtp
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: h77. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (562 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2xni
Protein-ligand complex of a novel macrocyclic hcv ns3 protea inhibitor derived from amino cyclic boronates
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: h. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Strain: h
Chains: A, B (181 residues) CATH domains: 2.40.10.120 2.40.10.10
2xwh
Hcv-j6 ns5b polymerase structure at 1.8 angstrom
Source: Hepatitis c virus isolate hc-j6. Organism_taxid: 11113. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (561 residues) CATH domains: Unassigned Unassigned
2xwy
Structure of mk-3281, a potent non-nucleoside finger-loop inhibitor, in complex with the hepatitis c virus ns5b polymerase
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: isolate bk. Variant: genotype 1b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (507 residues) CATH domains: Unassigned Unassigned 3.30.70.270
2xxd
Hcv-jfh1 ns5b polymerase structure at 1.9 angstrom
Source: Hepatitis c virus. Hcv. Organism_taxid: 11103. Strain: jfh1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.
Chain: A (563 residues) CATH domains: Unassigned Unassigned
2xym
Hcv-jfh1 ns5b t385a mutant
Source: Hepatitis c virus. Organism_taxid: 356411. Strain: jfh-1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (563 residues) CATH domains: Unassigned Unassigned
2yoj
Hcv ns5b polymerase complexed with pyridonylindole compound
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (563 residues) CATH domains: Unassigned Unassigned
2zjo
Crystal structure of hepatitis c virus ns3 helicase with a novel inhibitor
Source: Hepatitis c virus (isolate taiwan). Viruses. Organism_taxid: 31645. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (444 residues) CATH domains: 3.40.50.300 3.40.50.300 1.10.820.10
2zku
Structure of hepatitis c virus ns5b polymerase in a new crys
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Strain: bk isolate. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (562 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3br9
Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: genotype 1b bk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3bsa
Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Strain: genotype 1b bk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3bsc
Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Strain: genotype 1b bk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3cde
Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor
Source: Hepatitis c virus. Strain: genotype 1b bk. Expressed in: escherichia coli.
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3ciz
Crystal structure of hepatitis c virus RNA-dependent RNA pol ns5b in complex with small molecule fragments
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Strain: genotype 1b. Strain bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (562 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3cj0
Crystal structure of hepatitis c virus RNA-dependent RNA polymerase ns5b in complex with small molecule fragments
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Strain: genotype 1b. Strain bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (562 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3cj2
Crystal structure of hepatitis c virus RNA-dependent RNA polymerase ns5b in complex with optimized small molecule fragments
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Strain: genotype 1b. Strain bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3cj3
Crystal structure of hepatitis c virus RNA-dependent RNA polymerase ns5b in complex with optimized small molecule fragments
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Strain: genotype 1b. Strain bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (560 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3cj4
Crystal structure of hepatitis c virus RNA-dependent RNA polymerase ns5b in complex with optimized small molecule fragments
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Strain: genotype 1b. Strain bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (558 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3cj5
Crystal structure of hepatitis c virus RNA-dependent RNA polymerase ns5b in complex with optimized small molecule fragments
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Strain: genotype 1b. Strain bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (562 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3co9
Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (562 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3cso
Hcv polymerase in complex with a 1,5 benzodiazepine inhibito
Source: Hepatitis c virus isolate. Organism_taxid: 420174. Strain: hc-j4. Gene: hcv-ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (561 residues) CATH domains: Unassigned Unassigned
3cvk
Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3cwj
Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor
Source: Hepatitis c virus. Strain: genotype 1b bk. Expressed in: escherichia coli.
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3d28
Crystal structure of hcv ns5b polymerase with a novel benzisothiazole inhibitor
Source: Hepatitis c virus (isolate bk). Hcv. Organism_taxid: 11105. Strain: genotype 1b bk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3d5m
Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Strain: genotype 1b bk. Expressed in: escherichia coli.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3e51
Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor
Source: Hepatitis c virus (isolate bk). Hcv. Organism_taxid: 11105. Strain: genotype 1b bk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3eyd
Structure of hcv ns3-4a protease with an inhibitor derived from a boronic acid
Source: Hepatitis c virus subtype 1a. Organism_taxid: 31646. Strain: h77 strain of genotype 1a. Gene: ns3. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: peptides were synthesized using fmoc solid- phase chemistry on an abi 431 synthesizer (foster city,
Chains: A, B, C, D (181 residues) CATH domains: 2.40.10.120 2.40.10.10
3fqk
Hepatitis c virus polymerase ns5b (bk 1-570) with hcv-796 inhibitor
Source: Hepatitis c virus. Hcv. Organism_taxid: 11105. Strain: bk. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3fql
Hepatitis c virus polymerase ns5b (con1 1-570) with hcv-796
Source: Hepatitis c virus. Hcv. Organism_taxid: 333284. Strain: con 1. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (560 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3fqm
Crystal structure of a novel dimeric form of hcv ns5a domain
Source: Hepatitis c virus (isolate con1). Hcv. Organism_taxid: 333284. Strain: hcv genotype 1b. Subtype con1. Gene: nonstructural protein 5a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (160 residues) CATH domains: Unassigned Unassigned
3fqq
Crystal structure of a novel dimeric form of hcv ns5a domain
Source: Hepatitis c virus (isolate con1). Hcv. Organism_taxid: 333284. Strain: hcv genotype 1b. Subtype con1. Gene: nonstructural protein ns5a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (160 residues) CATH domains: Unassigned Unassigned
3frz
Crystal structure of hcv ns5b RNA polymerase in complex with
Source: Hepatitis c virus. Organism_taxid: 11105. Strain: 1b. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (562 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3g86
Hepatitis c virus polymerase ns5b (bk 1-570) with thiazine inhibitor
Source: Hepatitis c virus. Organism_taxid: 11105. Strain: bk. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3gnv
Hcv ns5b polymerase in complex with 1,5 benzodiazepine inhib
Source: Hepatitis c virus isolate. Hcv. Organism_taxid: 420174. Strain: hc-j4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (563 residues) CATH domains: Unassigned Unassigned
3gnw
Hcv ns5b polymerase in complex with 1,5 benzodiazepine inhib
Source: Hepatitis c virus isolate. Hcv. Organism_taxid: 420174. Strain: hc-j4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (560 residues) CATH domains: Unassigned Unassigned
3gol
Hcv ns5b polymerase in complex with 1,5 benzodiazepine inhib 11d
Source: Hepatitis c virus isolate. Hcv. Organism_taxid: 420174. Strain: hc-j4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned
3gsz
Structure of the genotype 2b hcv polymerase
Source: Hepatitis c virus isolate hc-j8. Hcv. Organism_taxid: 11115. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (558 residues) CATH domains: Unassigned Unassigned
3gyn
Crystal structure of hcv ns5b polymerase with a novel monocyclic dihydropyridinone inhibitor
Source: Hepatitis c virus (isolate bk). Hcv. Organism_taxid: 11105. Strain: genotype 1b bk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3h2l
Crystal structure of hcv ns5b polymerase in complex with a novel bicyclic dihydro-pyridinone inhibitor
Source: Hepatitis c virus (isolate bk). Virus. Organism_taxid: 11105. Strain: genotype 1b, isolate bk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3h59
Hepatitis c virus polymerase ns5b with thiazine inhibitor 2
Source: Hepatitis c virus. Organism_taxid: 11105. Strain: bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3h5s
Hepatitis c virus polymerase ns5b with saccharin inhibitor
Source: Hepatitis c virus. Organism_taxid: 11105. Strain: bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3h5u
Hepatitis c virus polymerase ns5b with saccharin inhibitor 1
Source: Hepatitis c virus. Organism_taxid: 11105. Strain: bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3h98
Crystal structure of hcv ns5b 1b with (1,1-dioxo-2h-[1,2, 4]benzothiadiazin-3-yl) azolo[1,5-a]pyrimidine derivative
Source: Hepatitis c virus (isolate bk). Hcv. Organism_taxid: 11105. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (551 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3hkw
Hcv ns5b genotype 1a in complex with 1,5 benzodiazepine inhi
Source: Hepatitis c virus subtype 1a. Organism_taxid: 31646. Gene: hcv infected patient. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (561 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3hky
Hcv ns5b polymerase genotype 1b in complex with 1,5 benzodia
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Strain: strain hc-j4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (564 residues) CATH domains: Unassigned Unassigned
3hvo
Structure of the genotype 2b hcv polymerase bound to a nni
Source: Hepatitis c virus isolate hc-j8. Hcv. Organism_taxid: 11115. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
3i5k
Crystal structure of the ns5b polymerase from hepatitis c vi strain jfh1
Source: Hepatitis c virus jfh-1. Hcv. Organism_taxid: 356411. Strain: genotype 2a, strain jfh1. Gene: ns5b, p68. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (566 residues) CATH domains: Unassigned Unassigned
3igv
Crystal structure of hcv ns5b polymerase with a novel monocyclic dihydro-pyridinone inhibitor
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Strain: genotype 1b bk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3kn2
Hcv ns3 protease domain with ketoamide inhibitor
Source: Hepatitis c virus subtype 1a. Organism_taxid: 31646. Strain: h77 strain of genotype 1a. Gene: ns3. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthesized using fmoc solid-phase chemistry
Chains: A, B, C, D (181 residues) CATH domains: 2.40.10.120 2.40.10.10
3kqh
Three conformational snapshots of the hepatitis c virus ns3 helicase reveal a ratchet translocation mechanism
Source: Hepatitis c virus. Hcv. Organism_taxid: 333284. Strain: con1. Gene: ns3. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chains: A, B (436 residues) CATH domains: 3.40.50.300 3.40.50.300 1.10.820.10
3kqk
Three conformational snapshots of the hepatitis c virus ns3 helicase reveal a ratchet translocation mechanism
Source: Hepatitis c virus. Hcv. Organism_taxid: 333284. Strain: con1. Gene: ns3. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chains: A, B (436 residues) CATH domains: 3.40.50.300 3.40.50.300 1.10.820.10
3kql
Three conformational snapshots of the hepatitis c virus ns3 helicase reveal a ratchet translocation mechanism
Source: Hepatitis c virus. Hcv. Organism_taxid: 333284. Strain: con1. Gene: ns3. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chains: A, B (437 residues) CATH domains: 3.40.50.300 3.40.50.300 1.10.820.10
3kqn
Three conformational snapshots of the hepatitis c virus ns3 helicase reveal a ratchet translocation mechanism
Source: Hepatitis c virus. Hcv. Organism_taxid: 333284. Strain: con1. Gene: ns3. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chain: A (437 residues) CATH domains: 3.40.50.300 3.40.50.300 1.10.820.10
3kqu
Three conformational snapshots of the hepatitis c virus ns3 helicase reveal a ratchet translocation mechanism
Source: Hepatitis c virus. Hcv. Organism_taxid: 333284. Strain: con1. Gene: ns3. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chains: A, B, C, D, E, F (437 residues) CATH domains: 3.40.50.300 3.40.50.300 1.10.820.10
3lkh
Inhibitors of hepatitis c virus polymerase: synthesis and characterization of novel 6-fluoro-n-[2-hydroxy-1(s)-benzam
Source: Hepatitis c virus. Hcv. Organism_taxid: 11103. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (554 residues) CATH domains: Unassigned Unassigned
3mf5
Hepatitis c virus polymerase ns5b (bk) with amide bioisoster site inhibitor
Source: Hepatitis c virus. Hcv. Organism_taxid: 11105. Strain: isolate bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3mwv
Crystal structure of hcv ns5b polymerase
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: hc-j4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
3mww
Crystal structure of hcv ns5b polymerase
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: hc-j4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
3oyp
Hcv ns3/4a in complex with ligand 3
Source: Hepatitis c virus (isolate japanese). Hcv. Organism_taxid: 11116. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B, C, D (174 residues) CATH domains: 2.40.10.120 2.40.10.10
3p8n
Crystal structure of hcv ns3/ns4a protease complexed with bi
Source: Hepatitis c virus. Hcv. Organism_taxid: 11116. Strain: isolate japanese. Gene: polg_hcvja. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B, C (182 residues) CATH domains: 2.40.10.120 2.40.10.10
3p8o
Crystal structure of hcv ns3/ns4a protease complexed with de analogue of bi 201335
Source: Hepatitis c virus. Hcv. Organism_taxid: 11116. Strain: isolate japanese. Gene: polg_hcvja. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B, D (182 residues) CATH domains: 2.40.10.120 2.40.10.10
3q0z
Crystal structure of the hepatitis c virus ns5b RNA-dependen polymerase complex with (2e)-3-(4-{[(1-{[(13-cyclohexyl-6-o dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl) carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-eno
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Strain: bartenschlager. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (551 residues) CATH domains: Unassigned Unassigned
3qgd
Crystal structure of the hepatitis c virus ns5b RNA-dependen polymerase complex with (2e)-3-(4-{[(1-{[(13-cyclohexyl-6-o dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl) carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-eno and (2r)-4-(2,6-dimethoxypyrimidin-4-yl)-1-[(4-ethylphenyl) n-(4-methoxybenzyl)piperazine-2-carboxamide
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Strain: bartenschlager. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (538 residues) CATH domains: Unassigned Unassigned
3qge
Crystal structure of the hepatitis c virus ns5b RNA-dependen polymerase complex with (2e)-3-(4-{[(1-{[(13-cyclohexyl-6-o dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl) carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-eno and (2r)-4-(2,6-dimethoxypyrimidin-4-yl)-n-(4-methoxybenzyl (trifluoromethoxy)phenyl]sulfonyl}piperazine-2-carboxamide
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Strain: bartenschlager. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (541 residues) CATH domains: Unassigned Unassigned
3qgf
Crystal structure of the hepatitis c virus ns5b RNA-dependen polymerase complex with (2e)-3-(4-{[(1-{[(13-cyclohexyl-6-o dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl) carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-eno and (2r)-4-(6-chloropyridazin-3-yl)-n-(4-methoxybenzyl)-1-{ (trifluoromethoxy)phenyl]sulfonyl}piperazine-2-carboxamide
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Strain: bartenschlager. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (534 residues) CATH domains: Unassigned Unassigned
3qgg
Crystal structure of the hepatitis c virus ns5b RNA-dependen polymerase complex with (2e)-3-(4-{[(1-{[(13-cyclohexyl-6-o dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl) carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-eno and n-cyclopropyl-6-[(3r)-3-{[4-(trifluoromethoxy)benzyl]ca 4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyri carboxamide
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Strain: bartenschlager. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (531 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3qgh
Crystal structure of the hepatitis c virus ns5b RNA-dependen polymerase genotype 1a complex with n-cyclopropyl-6-[(3r)-3 (trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide
Source: Hepatitis c virus subtype 1a. Organism_taxid: 31646. Strain: bartenschlager. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (559 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3qgi
Crystal structure of the hepatitis c virus ns5b RNA-dependen polymerase genotype 1a complex with n-[(2s)-butan-2-yl]-6-[ {[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromet phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide
Source: Hepatitis c virus subtype 1a. Organism_taxid: 31646. Strain: bartenschlager. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (561 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3rc4
Molecular mechanisms of viral and host-cell substrate recogn hcv ns3/4a protease
Source: Hepatitis c virus subtype 1a. Organism_taxid: 31646. Gene: ns3. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
Chain: A (199 residues) CATH domains: 2.40.10.120 2.40.10.10
3rc5
Molecular mechanisms of viral and host-cell substrate recogn hcv ns3/4a protease
Source: Hepatitis c virus subtype 1a. Organism_taxid: 31646. Gene: ns3. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
Chain: A (198 residues) CATH domains: 2.40.10.120 2.40.10.10
3ska
I. Novel hcv ns5b polymerase inhibitors: discovery of indole carboxylic acids with c3-heterocycles
Source: Hepatitis c virus isolate hc-j4. Hcv. Organism_taxid: 420174. Strain: hc-j4. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (563 residues) CATH domains: Unassigned Unassigned
3ske
I. Novel hcv ns5b polymerase inhibitors: discovery of indole carboxylic acids with c3-heterocycles
Source: Hepatitis c virus isolate hc-j4. Hcv. Organism_taxid: 420174. Strain: hc-j4. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (563 residues) CATH domains: Unassigned Unassigned
3skh
I. Novel hcv ns5b polymerase inhibitors: discovery of indole carboxylic acids with c3-heterocycles
Source: Hepatitis c virus isolate hc-j4. Hcv. Organism_taxid: 420174. Strain: hc-j4. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (558 residues) CATH domains: Unassigned Unassigned
3tyq
Sar development and discovery of potent indole-based inhibit hepatitis c virus ns5b polymerase
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: hc-j4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (563 residues) CATH domains: Unassigned Unassigned
3tyv
Sar development and discovery of potent indole-based inhibit hepatitis c virus ns5b polymerase
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: hc-j4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (563 residues) CATH domains: Unassigned Unassigned
3u4o
Novel hcv ns5b polymerase inhibitors: discovery of indole c2 sulfonamides
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: hc-j4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (563 residues) CATH domains: Unassigned Unassigned
3u4r
Novel hcv ns5b polymerase inhibitors: discovery of indole c2 sulfonamides
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: hc-j4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (558 residues) CATH domains: Unassigned Unassigned
3udl
3-heterocyclyl quinolone bound to hcv ns5b
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (555 residues) CATH domains: Unassigned Unassigned 3.30.70.270
3uph
Synthesis of novel 4,5-dihydrofurano indoles and their evalu hcv ns5b polymerase inhibitors
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: hc-j4. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (563 residues) CATH domains: Unassigned Unassigned
3upi
Synthesis of novel 4,5-dihydrofurano indoles and their evalu hcv ns5b polymerase inhibitors
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: hc-j4. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (563 residues) CATH domains: Unassigned Unassigned
3vqs
Crystal structure of hcv ns5b RNA polymerase with a novel pi inhibitor
Source: Hepatitis c virus. Organism_taxid: 11103. Strain: bk. Gene: genotype 1b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (553 residues) CATH domains: Unassigned Unassigned 3.30.70.270
4a1t
Co-complex of the of ns3-4a protease with the inhibitory peptide cp5-46-a (in-house data)
Source: Hepatitis c virus. Organism_taxid: 31647. Strain: 1b. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta2. Other_details: hcv replicon i389/ns3-3'utr (aj242654). Synthetic: yes. Synthetic construct.
Chains: A, B (193 residues) CATH domains: 2.40.10.120 2.40.10.10
4a1v
Co-complex structure of ns3-4a protease with the optimized inhibitory peptide cp5-46a-4d5e
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta2. Other_details: hcv replicon i389/ns3-3'utr (aj242654). Synthetic: yes. Synthetic construct. Organism_taxid: 32630
Chains: A, B (190 residues) CATH domains: 2.40.10.120 2.40.10.10
4a1x
Co-complex structure of ns3-4a protease with the inhibitory peptide cp5-46-a (synchrotron data)
Source: Hepatitis c virus subtype 1b. Organism_taxid: 31647. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta2. Other_details: hcv replicon i389/ns3-3'utr (aj242654). Synthetic: yes. Synthetic construct. Organism_taxid: 32630.
Chains: A, B (191 residues) CATH domains: 2.40.10.120 2.40.10.10
4a92
Full-length hcv ns3-4a protease-helicase in complex with a macrocyclic protease inhibitor.
Source: Hepatitis c virus. Hcv. Organism_taxid: 11103. Strain: 1b. Variant: bk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (639 residues) CATH domains: 2.40.10.120 2.40.10.10 3.40.50.300 3.40.50.300 1.10.820.10
4adp
Hcv-j6 ns5b polymerase v405i mutant
Source: Hepatitis c virus. Hcv. Organism_taxid: 11103. Strain: j6. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (564 residues) CATH domains: Unassigned Unassigned
4aep
Hcv-jfh1 ns5b polymerase structure at 1.8 angstrom
Source: Hepatitis c virus. Hcv. Organism_taxid: 11103. Strain: jfh1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.
Chain: A (563 residues) CATH domains: Unassigned Unassigned
4aex
Hcv-jfh1 ns5b polymerase structure at 2.4 angstrom in a primitive orthorhombic space group
Source: Hepatitis c virus. Hcv. Organism_taxid: 11103. Strain: jfh1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.
Chains: A, B (563 residues) CATH domains: Unassigned Unassigned
4b6e
Discovery of an allosteric mechanism for the regulation of hcv ns3 protein function
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Strain: genotype 1b. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (646 residues) CATH domains: Unassigned 3.40.50.300 3.40.50.300 1.10.820.10
4b6f
Discovery of an allosteric mechanism for the regulation of hcv ns3 protein function
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Strain: genotype 1b. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (646 residues) CATH domains: Unassigned 3.40.50.300 3.40.50.300 1.10.820.10
4b71
Discovery of an allosteric mechanism for the regulation of hcv ns3 protein function
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Strain: genotype 1b. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.
Chains: A, B (645 residues) CATH domains: 2.40.10.120 2.40.10.10 3.40.50.300 3.40.50.300 1.10.820.10
4b73
Discovery of an allosteric mechanism for the regulation of hcv ns3 protein function
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Strain: genotype 1b. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.
Chains: A, B (645 residues) CATH domains: 2.40.10.120 2.40.10.10 3.40.50.300 3.40.50.300 1.10.820.10
4b74
Discovery of an allosteric mechanism for the regulation of hcv ns3 protein function
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Strain: genotype 1b. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: rosetta.
Chains: A, B (645 residues) CATH domains: 2.40.10.120 2.40.10.10 3.40.50.300 3.40.50.300 1.10.820.10
4b75
Discovery of an allosteric mechanism for the regulation of hcv ns3 protein function
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Strain: genotype 1b. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.
Chains: A, B (645 residues) CATH domains: 2.40.10.120 2.40.10.10 3.40.50.300 3.40.50.300 1.10.820.10
4b76
Discovery of an allosteric mechanism for the regulation of hcv ns3 protein function
Source: Hepatitis c virus (isolate bk). Organism_taxid: 11105. Strain: genotype 1b. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.
Chains: A, B (645 residues) CATH domains: 2.40.10.120 2.40.10.10 3.40.50.300 3.40.50.300 1.10.820.10
4dgv
Structure of the hepatitis c virus envelope glycoprotein e2 region 412-423 bound to the broadly neutralizing antibody h form
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293 freestyle. Synthetic: yes. Hepatitis c virus. Organism_taxid: 11103
Chain: A (13 residues)
4dgy
Structure of the hepatitis c virus envelope glycoprotein e2 region 412-423 bound to the broadly neutralizing antibody h form
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293 freestyle. Synthetic: yes. Hepatitis c virus. Organism_taxid: 11103
Chain: A (12 residues)
4dru
Hcv ns5b in complex with macrocyclic indole inhibitor
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: hc-j4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (549 residues) CATH domains: Unassigned Unassigned
4e76
Apo crystal structure of hcv ns5b genotype 2a jfh-1 isolate hairpin loop deletion
Source: Hepatitis c virus. Hcv. Organism_taxid: 356411. Strain: jfh-1. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (544 residues) CATH domains: Unassigned Unassigned
4e78
Crystal structure of a product state assembly of hcv ns5b ge jfh-1 isolate with beta hairpin loop deletion bound to prim template RNA with 3'-dg
Source: Synthetic: yes. Hepatitis c virus. Hcv. Organism_taxid: 356411. Strain: jfh-1. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (538 residues) CATH domains: Unassigned Unassigned
4e7a
Crystal structure of a product state assembly of hcv ns5b ge jfh-1 isolate with beta hairpin deletion bound to primer-te with a 2',3'-ddc
Source: Synthetic: yes. Hepatitis c virus. Hcv. Organism_taxid: 356411. Strain: jfh-1. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (536 residues) CATH domains: Unassigned Unassigned
4eaw
Hcv ns5b in complex with idx375
Source: Hepatitis c virus subtype 1b. Hcv. Organism_taxid: 31647. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
4eo6
Hcv ns5b polymerase inhibitors: tri-substituted acylhydrazin tertiary amide bioisosteres
Source: Hepatitis c virus (isolate bk). Hcv. Organism_taxid: 11105. Strain: bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
4eo8
Hcv ns5b polymerase inhibitors: tri-substituted acylhydrazin tertiary amide bioisosteres
Source: Hepatitis c virus (isolate bk). Hcv. Organism_taxid: 11105. Strain: bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
4gmc
Crystal structure of hcv ns5b polymerase in complex with a t inhibitor
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: hc-j4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
4i31
Crystal structure of hcv ns3/ns4a protease complexed with co
Source: Hepatitis c virus. Hcv. Organism_taxid: 11116. Strain: isolate japanese. Gene: polg_hcvja. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemically synthesized
Chains: A, B, C, D (182 residues) CATH domains: 2.40.10.120 2.40.10.10
4i32
Crystal structure of hcv ns3/4a d168v protease complexed wit 4
Source: Hepatitis c virus. Hcv. Organism_taxid: 11116. Strain: isolate japanese. Gene: polg_hcvja. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemically synthesized
Chains: A, B, C, D (182 residues) CATH domains: 2.40.10.120 2.40.10.10
4i33
Crystal structure of hcv ns3/4a r155k protease complexed wit 4
Source: Hepatitis c virus. Hcv. Organism_taxid: 11116. Strain: isolate japanese. Gene: polg_hcvja. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemically synthesized
Chains: A, B, C, D (182 residues) CATH domains: 2.40.10.120 2.40.10.10
4ih5
Hepatitis c virus polymerase ns5b (bk) with fragment-based c
Source: Hepatitis c virus. Hcv. Organism_taxid: 11105. Strain: isolate bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
4ih6
Hepatitis c virus polymerase ns5b (bk) with fragment-based c
Source: Hepatitis c virus. Hcv. Organism_taxid: 11105. Strain: isolate bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
4ih7
Hepatitis c virus polymerase ns5b (bk) with fragment-based c
Source: Hepatitis c virus. Hcv. Organism_taxid: 11105. Strain: isolate bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
4iz0
Crystal structure of hcv ns5b polymerase in complex with 2,4 trichloro-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: hc-j4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
4j02
Crystal structure of hcv ns5b polymerase in complex with [(1 dichloro-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl acid
Source: Hepatitis c virus isolate. Organism_taxid: 420174. Strain: 1bj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
4j04
Crystal structure of hcv ns5b polymerase in complex with 4-c {[(2,4,5-trichlorophenyl)sulfonyl]amino}benzoic acid
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: 1b-j4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
4j06
Crystal structure of hcv ns5b polymerase in complex with 2-{ bromothiophen-2-yl)sulfonyl]amino}-4-chlorobenzoic acid
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: 1bj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
4j08
Crystal structure of hcv ns5b polymerase in complex with 2-{ methylphenyl)sulfonyl]amino}-5-phenoxybenzoic acid
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: 1bj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
4j0a
Crystal structure of hcv ns5b polymerase in complex with 2-{ methylphenyl)sulfonyl]amino}-4-phenoxybenzoic acid
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: ibj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
4j1v
Functional and structural studies of mobkl1b, a salvador/war tumor suppressor pathway, in hcv replication
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mob1a, c2orf6, mob4b, mobk1b, mobkl1b. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Hepatitis c virus. Hcv.
Chains: G, H (15 residues)
4jjs
Crystal structure of hcv ns5b polymerase in complex with com
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: ibj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
4jju
Crystal structure of hcv ns5b polymerase in complex with com
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: 1bj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
4jmy
Crystal structure of hcv ns3/ns4a protease complexed with dd peptide
Source: Hepatitis c virus genotype 2. Organism_taxid: 40271. Strain: isolate japanes, taxonomy id: 11116. Gene: polg_hcvja. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemically synthesized. Other_details: chemically synthesized
Chains: A, C (182 residues) CATH domains: 2.40.10.120 2.40.10.10
4jtw
Crystal structure of hcv ns5b polymerase in complex with cou
Source: Hepatitis c virus. Organism_taxid: 420174. Strain: 1bj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (560 residues) CATH domains: Unassigned Unassigned
4jty
Crystal structure of hcv ns5b polymerase with compound 2
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: 1bj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (560 residues) CATH domains: Unassigned Unassigned
4jtz
Crystal structure of hcv ns5b polymerase in complex with com
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: 1bj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (560 residues) CATH domains: Unassigned Unassigned
4ju1
Crystal structure of hcv ns5b polymerase in complex with com
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: 1bj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (560 residues) CATH domains: Unassigned Unassigned
4ju2
Crystal structure of hcv ns5b polymerase in complex with com
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: 1bj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (560 residues) CATH domains: Unassigned Unassigned
4ju3
Crystal structure of hcv ns5b polymerase in complex with com
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: 1bj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
4ju4
Crystal structure of hcv ns5b polymerase in complex with com
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: 1bj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
4ju6
Crystal structure of hcv ns5b polymerase in complex with com
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: 1bj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
4ju7
Crystal structure of hcv ns5b polymerase in complex with com
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: 1bj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues) CATH domains: Unassigned Unassigned
4jvq
Crystal structure of hcv ns5b polymerase in complex with com
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: 1bj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (560 residues) CATH domains: Unassigned Unassigned
4jy0
Crystal structure of hcv ns5b polymerase in complex with com
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: ibj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues)
4jy1
Crystal structure of hcv ns5b polymerase in complex with com
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: 1bj4. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (559 residues)
4k8b
Crystal structure of hcv ns3/4a protease complexed with inhi
Source: Hepatitis c virus. Organism_taxid: 11103. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ns3-ns4. Expression_system_taxid: 562
Chains: C, D (12 residues)
4kai
Hcv ns5b gt1b n316 with gsk5852a
Source: Hepatitis c virus. Hcv. Organism_taxid: 31647. Strain: genotype 1b. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: ?469008.
Chains: A, B (552 residues) CATH domains: Unassigned Unassigned 3.30.70.270
4kb7
Hcv ns5b gt1b n316y with cmpd 32
Source: Hepatitis c virus. Hcv. Organism_taxid: 31647. Strain: genotype 1b. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (545 residues) CATH domains: Unassigned Unassigned 3.30.70.270
4kbi
Hcv ns5b gt1b n316y with cmpd 4
Source: Hepatitis c virus. Hcv. Organism_taxid: 31647. Strain: genotype 1b. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (544 residues) CATH domains: Unassigned Unassigned 3.30.70.270
4ke5
Hcv ns5b gt1b n316y with gsk5852
Source: Hepatitis c virus. Hcv. Organism_taxid: 31647. Strain: genotype 1b. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (548 residues) CATH domains: Unassigned Unassigned 3.30.70.270
4ktc
Ns3/ns4a protease with inhibitor
Source: Hepatitis c virus (isolate japanese). Hcv. Organism_taxid: 11116. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic. Organism_taxid: 32630. Other_details: solid-phase peptide synthesis
Chains: A, C (175 residues) CATH domains: 2.40.10.120 2.40.10.10
4mia
Hepatitis c virus polymerase ns5b genotype 1b (bk) in comple rg7109 (n-{4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-2,5 dihydropyridin-3-yl)quinolin-3-yl]phenyl}methanesulfonamide
Source: Hepatitis c virus. Hcv. Organism_taxid: 11105. Strain: 1b bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (546 residues)
4mib
Hepatitis c virus polymerase ns5b genotype 1b (bk) in comple compound 48 (n-({(3s)-1-[6-tert-butyl-5-methoxy-8-(2-oxo-1, dihydropyridin-3-yl)quinolin-3-yl]pyrrolidin-3-yl}methyl) methanesulfonamide)
Source: Hepatitis c virus. Hcv. Organism_taxid: 11105. Strain: 1b bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues)
4mk7
Hepatitis c virus polymerase ns5b genotype 1b (bk) in comple inhibitor 2 (3-(3-tert-butyl-4-methoxyphenyl)pyridin-2(1h)-
Source: Hepatitis c virus. Hcv. Organism_taxid: 11105. Strain: 1b bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
4mk8
Hepatitis c virus polymerase ns5b genotype 1b (bk) in comple inhibitor 4 (n-(4-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2- dihydropyridin-3-yl)phenyl]ethyl}phenyl)methanesulfonamide)
Source: Hepatitis c virus. Hcv. Organism_taxid: 11105. Strain: 1b bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
4mk9
Hepatitis c virus polymerase ns5b genotype 1b (bk) in comple inhibitor 12 (n-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2- dihydropyridin-3-yl)phenyl]-1,3-benzoxazol-5-yl}methanesulf
Source: Hepatitis c virus. Hcv. Organism_taxid: 11105. Strain: 1b bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
4mka
Hepatitis c virus polymerase ns5b genotype 1b (bk) in comple inhibitor 13 (n-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2- dihydropyridin-3-yl)phenyl]-1,3-benzoxazol-5-yl}methanesulf
Source: Hepatitis c virus. Hcv. Organism_taxid: 11105. Strain: 1b bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
4mkb
Hepatitis c virus polymerase ns5b genotype 1b (bk) in comple inhibitor 14 (n-(4-{(e)-2-[3-tert-butyl-2-methoxy-5-(3-oxo- dihydropyridazin-4-yl)phenyl]ethenyl}phenyl)methanesulfonam
Source: Hepatitis c virus. Hcv. Organism_taxid: 11105. Strain: 1b bk. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (557 residues) CATH domains: Unassigned Unassigned 3.30.70.270
4mwf
Structure of hepatitis c virus envelope glycoprotein e2 core broadly neutralizing antibody ar3c
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Hepatitis c virus (isolate h). Hcv. Organism_taxid: 11108. Expressed in: homo sapiens.
Chains: C, D (169 residues)
4mz4
Discovery of an irreversible hcv ns5b polymerase inhibitor
Source: Hepatitis c virus. Hcv. Organism_taxid: 420174. Strain: hc-j4. Gene: ns5b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (563 residues) CATH domains: Unassigned Unassigned
4nld
Crystal structure of the hepatitis c virus ns5b RNA-dependen polymerase complex with bms-791325 also known as (1ar,12bs) cyclohexyl-n-(dimethylsulfamoyl)-11-methoxy-1a-{[(1r,5s)-3- 8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b- tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carbox 2-(4-fluorophenyl)-n-methyl-6-[(methylsulfonyl)amino]-5-(pr yloxy)-1-benzofuran-3-carboxamide
Source: Hepatitis c virus. Hcv. Organism_taxid: 333284. Strain: bartenschlager. Gene: ns5b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (500 residues)
4obc
Crystal structure of hcv polymerase ns5b genotype 2a jfh-1 i with the s15g, c223h, v321i resistance mutations against th guanosine analog gs-0938 (psi-3529238)
Source: Hepatitis c virus jfh-1. Hcv. Organism_taxid: 356411. Strain: jfh-1. Gene: polg_hcvjf. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (554 residues)
8ohm
Crystal structure of RNA helicase from genotype 1b hepatitis c virus: mechanism of unwinding duplex RNA
Source: Hepatitis c virus. Organism_taxid: 11103. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (435 residues) CATH domains: 3.40.50.300 3.40.50.300 1.10.820.10