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PDBsum entry 2b7z
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Viral protein
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PDB id
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2b7z
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Contents |
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* Residue conservation analysis
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PDB id:
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Viral protein
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Title:
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Structure of HIV-1 protease mutant bound to indinavir
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Structure:
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HIV-1 protease. Chain: b, a. Engineered: yes. Mutation: yes
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Source:
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Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Biol. unit:
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Dimer (from
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Resolution:
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2.20Å
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R-factor:
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0.216
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R-free:
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0.254
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Authors:
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J.C.Clemente,L.R.Stow,L.K.Janka,J.A.Jeung,K.A.Desai,L.Govindasamy, M.Agbandje-Mckenna,R.Mckenna,M.M.Goodenow,B.M.Dunn
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Key ref:
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J.C.Clemente
et al.
In vivo, Kinetic, And structural analysis of the development of ritonavir resistance.
To be published,
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Date:
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05-Oct-05
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Release date:
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14-Nov-06
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PROCHECK
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Headers
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References
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P03367
(POL_HV1BR) -
Gag-Pol polyprotein from Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)
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Seq:
Struc:
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1447 a.a.
99 a.a.*
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Key: |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 10 residue positions (black
crosses)
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Enzyme class 1:
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E.C.2.7.7.-
- ?????
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Enzyme class 2:
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E.C.2.7.7.49
- RNA-directed Dna polymerase.
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Reaction:
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DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate
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DNA(n)
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+
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2'-deoxyribonucleoside 5'-triphosphate
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=
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DNA(n+1)
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+
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diphosphate
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Enzyme class 3:
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E.C.2.7.7.7
- DNA-directed Dna polymerase.
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Reaction:
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DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate
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DNA(n)
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+
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2'-deoxyribonucleoside 5'-triphosphate
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=
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DNA(n+1)
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+
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diphosphate
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Enzyme class 4:
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E.C.3.1.-.-
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Enzyme class 5:
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E.C.3.1.13.2
- exoribonuclease H.
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Reaction:
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Exonucleolytic cleavage to 5'-phosphomonoester oligonucleotides in both 5'- to 3'- and 3'- to 5'-directions.
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Enzyme class 6:
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E.C.3.1.26.13
- retroviral ribonuclease H.
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Enzyme class 7:
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E.C.3.4.23.16
- HIV-1 retropepsin.
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Reaction:
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Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
