|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
|
|
|
|
Enzyme class 1:
|
|
Chain A:
E.C.?
|
|
|
|
|
|
|
Enzyme class 2:
|
|
Chain B:
E.C.1.14.13.39
- nitric-oxide synthase (NADPH).
|
|
|
|
|
|
|
Reaction:
|
|
2 L-arginine + 3 NADPH + 4 O2 + H+ = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
|
|
|
|
|
|
2
×
L-arginine
|
+
|
3
×
NADPH
|
+
|
4
×
O2
|
+
|
H(+)
|
=
|
2
×
L-citrulline
|
+
|
2
×
nitric oxide
|
+
|
3
×
NADP(+)
|
+
|
4
×
H2O
|
|
|
|
|
|
|
|
|
|
|
|
|
Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
| |
|
DOI no:
|
Science
284:812-815
(1999)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex.
|
|
B.J.Hillier,
K.S.Christopherson,
K.E.Prehoda,
D.S.Bredt,
W.A.Lim.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
The PDZ protein interaction domain of neuronal nitric oxide synthase (nNOS) can
heterodimerize with the PDZ domains of postsynaptic density protein 95 and
syntrophin through interactions that are not mediated by recognition of a
typical carboxyl-terminal motif. The nNOS-syntrophin PDZ complex structure
revealed that the domains interact in an unusual linear head-to-tail
arrangement. The nNOS PDZ domain has two opposite interaction surfaces-one face
has the canonical peptide binding groove, whereas the other has a beta-hairpin
"finger." This nNOS beta finger docks in the syntrophin peptide
binding groove, mimicking a peptide ligand, except that a sharp beta turn
replaces the normally required carboxyl terminus. This structure explains how
PDZ domains can participate in diverse interaction modes to assemble protein
networks.
|
|
|
|
|
|
| |
Selected figure(s)
|
|
|
|
| |
|
|
|
|
|
|
Figure 1.
Fig. 1. Linear head-to-tail heterodimer of nNOS-syntrophin PDZ
domains. (A) The nNOS PDZ domain (orange) has a polarized
structure with distinct receptor (peptide binding groove) and
ligand (  -finger)
faces. The nNOS ligand face docks against the syntrophin PDZ
domain (purple) peptide binding groove. (B) Structure of the
syntrophin PDZ domain (purple) in complex with a COOH-terminal
peptide (orange) (10). The figure was generated with the program
MOLSCRIPT (25).
|
|
Figure 3.
Fig. 3. Recognition of internal motifs by PDZ domains. In (A)
through (C), the GLGF loop acts as a steric block at the end of
the binding groove, necessitating chain termination or a sharp
turn
immediately after the recognition motif. (A) Interaction
topology of a COOH-terminal peptide (orange) bound to PSD-95
PDZ3 (purple surface). (B) Interaction topology of the nNOS finger
(orange) with the syntrophin PDZ domain (purple surface). In (A)
and (B), the hydrophobic ligand residue that packs at site 0 is
shown in space-filling mode. Gray, carbon; red, oxygen. (C)
Schematic of structural requirements for PDZ domain recognition
of internal or COOH-terminal ligands. (D) Rigidly stabilized
structure of nNOS finger.
Overlay of C  traces of
the uncomplexed (orange) and complexed (grey) nNOS PDZ domain
structures, highlighting residues that stabilize the nNOS -finger
conformation. The main interaction is a salt bridge between
Arg^121 and Asp^62, which is buried by the surrounding
hydrophobic residues Ile^16, Leu^57, Pro^100, Phe^103, Thr^105,
Leu^107, and Thr^123. (E) Increased contact area in the PDZ
heterodimer through tertiary interactions. Solvent excluded
footprint of the nNOS PDZ domain (C trace
shown in orange) bound to the syntrophin PDZ domain (purple
surface, ~800 Å^2), compared to the footprint of a peptide
ligand (pink surface, ~400 Å^2). Images were generated
with the programs MOLSCRIPT (25) and WebLab Viewer Lite (26).
|
|
|
|
|
|
| |
The above figures are
reprinted
by permission from the AAAs:
Science
(1999,
284,
812-815)
copyright 1999.
|
|
| |
Figures were
selected
by an automated process.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
N.A.Mack,
A.P.Porter,
H.J.Whalley,
J.P.Schwarz,
R.C.Jones,
A.S.Khaja,
A.Bjartell,
K.I.Anderson,
and
A.Malliri
(2012).
β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity.
|
| |
Nat Cell Biol,
14,
1169-1180.
|
|
|
|
|
|
|
D.Gfeller,
F.Butty,
M.Wierzbicka,
E.Verschueren,
P.Vanhee,
H.Huang,
A.Ernst,
N.Dar,
I.Stagljar,
L.Serrano,
S.S.Sidhu,
G.D.Bader,
and
P.M.Kim
(2011).
The multiple-specificity landscape of modular peptide recognition domains.
|
| |
Mol Syst Biol,
7,
484.
|
|
|
|
|
|
|
D.Li,
Y.Yue,
Y.Lai,
C.H.Hakim,
and
D.Duan
(2011).
Nitrosative stress elicited by nNOSµ delocalization inhibits muscle force in dystrophin-null mice.
|
| |
J Pathol,
223,
88-98.
|
|
|
|
|
|
|
D.Oceandy,
T.M.Mohamed,
E.J.Cartwright,
and
L.Neyses
(2011).
Local signals with global impacts and clinical implications: lessons from the plasma membrane calcium pump (PMCA4).
|
| |
Biochim Biophys Acta,
1813,
974-978.
|
|
|
|
|
|
|
B.H.Cool,
G.C.Chan,
L.Lee,
J.Oshima,
G.M.Martin,
and
Q.Hu
(2010).
A flanking gene problem leads to the discovery of a Gprc5b splice variant predominantly expressed in C57Bl/6J mouse brain and in maturing neurons.
|
| |
PLoS One,
5,
e10351.
|
|
|
|
|
|
|
H.J.Lee,
and
J.J.Zheng
(2010).
PDZ domains and their binding partners: structure, specificity, and modification.
|
| |
Cell Commun Signal,
8,
8.
|
|
|
|
|
|
|
J.Li,
H.Kim,
D.G.Aceto,
J.Hung,
S.Aono,
and
K.J.Kemphues
(2010).
Binding to PKC-3, but not to PAR-3 or to a conventional PDZ domain ligand, is required for PAR-6 function in C. elegans.
|
| |
Dev Biol,
340,
88-98.
|
|
|
|
|
|
|
J.M.Elkins,
C.Gileadi,
L.Shrestha,
C.Phillips,
J.Wang,
J.R.Muniz,
and
D.A.Doyle
(2010).
Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms.
|
| |
Protein Sci,
19,
731-741.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
R.C.Tyler,
F.C.Peterson,
and
B.F.Volkman
(2010).
Distal interactions within the par3-VE-cadherin complex.
|
| |
Biochemistry,
49,
951-957.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.Stein,
R.A.Pache,
P.Bernadó,
M.Pons,
and
P.Aloy
(2009).
Dynamic interactions of proteins in complex networks: a more structured view.
|
| |
FEBS J,
276,
5390-5405.
|
|
|
|
|
|
|
C.Punchihewa,
A.M.Ferreira,
R.Cassell,
P.Rodrigues,
and
N.Fujii
(2009).
Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.
|
| |
Protein Sci,
18,
994.
|
|
|
|
|
|
|
D.P.LaLonde,
and
A.Bretscher
(2009).
The scaffold protein PDZK1 undergoes a head-to-tail intramolecular association that negatively regulates its interaction with EBP50.
|
| |
Biochemistry,
48,
2261-2271.
|
|
|
|
|
|
|
H.Chen,
S.Tong,
X.Li,
J.Wu,
Z.Zhu,
L.Niu,
and
M.Teng
(2009).
Structure of the second PDZ domain from human zonula occludens 2.
|
| |
Acta Crystallogr Sect F Struct Biol Cryst Commun,
65,
327-330.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
I.M.Stylianou,
K.L.Svenson,
S.K.VanOrman,
Y.Langle,
J.S.Millar,
B.Paigen,
and
D.J.Rader
(2009).
Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein.
|
| |
PLoS One,
4,
e6521.
|
|
|
|
|
|
|
J.E.Dueber,
G.C.Wu,
G.R.Malmirchegini,
T.S.Moon,
C.J.Petzold,
A.V.Ullal,
K.L.Prather,
and
J.D.Keasling
(2009).
Synthetic protein scaffolds provide modular control over metabolic flux.
|
| |
Nat Biotechnol,
27,
753-759.
|
|
|
|
|
|
|
K.Ellencrona,
A.Syed,
and
M.Johansson
(2009).
Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism.
|
| |
Biol Chem,
390,
319-323.
|
|
|
|
|
|
|
S.S.Yadav,
B.J.Yeh,
B.P.Craddock,
W.A.Lim,
and
W.T.Miller
(2009).
Reengineering the signaling properties of a Src family kinase.
|
| |
Biochemistry,
48,
10956-10962.
|
|
|
|
|
|
|
W.Feng,
and
M.Zhang
(2009).
Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density.
|
| |
Nat Rev Neurosci,
10,
87-99.
|
|
|
|
|
|
|
Y.Lai,
G.D.Thomas,
Y.Yue,
H.T.Yang,
D.Li,
C.Long,
L.Judge,
B.Bostick,
J.S.Chamberlain,
R.L.Terjung,
and
D.Duan
(2009).
Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy.
|
| |
J Clin Invest,
119,
624-635.
|
|
|
|
|
|
|
Z.N.Gerek,
O.Keskin,
and
S.B.Ozkan
(2009).
Identification of specificity and promiscuity of PDZ domain interactions through their dynamic behavior.
|
| |
Proteins,
77,
796-811.
|
|
|
|
|
|
|
A.C.Hanyaloglu,
and
M.von Zastrow
(2008).
Regulation of GPCRs by endocytic membrane trafficking and its potential implications.
|
| |
Annu Rev Pharmacol Toxicol,
48,
537-568.
|
|
|
|
|
|
|
A.Marchese,
M.M.Paing,
B.R.Temple,
and
J.Trejo
(2008).
G protein-coupled receptor sorting to endosomes and lysosomes.
|
| |
Annu Rev Pharmacol Toxicol,
48,
601-629.
|
|
|
|
|
|
|
K.Werme,
M.Wigerius,
and
M.Johansson
(2008).
Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling.
|
| |
Cell Microbiol,
10,
696-712.
|
|
|
|
|
|
|
L.Peng,
D.C.Popescu,
N.Wang,
and
B.H.Shieh
(2008).
Anchoring TRP to the INAD macromolecular complex requires the last 14 residues in its carboxyl terminus.
|
| |
J Neurochem,
104,
1526-1535.
|
|
|
|
|
|
|
R.Tonikian,
Y.Zhang,
S.L.Sazinsky,
B.Currell,
J.H.Yeh,
B.Reva,
H.A.Held,
B.A.Appleton,
M.Evangelista,
Y.Wu,
X.Xin,
A.C.Chan,
S.Seshagiri,
L.A.Lasky,
C.Sander,
C.Boone,
G.D.Bader,
and
S.S.Sidhu
(2008).
A specificity map for the PDZ domain family.
|
| |
PLoS Biol,
6,
e239.
|
|
|
|
|
|
|
S.M.Gisler,
S.Kittanakom,
D.Fuster,
V.Wong,
M.Bertic,
T.Radanovic,
R.A.Hall,
H.Murer,
J.Biber,
D.Markovich,
O.W.Moe,
and
I.Stagljar
(2008).
Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified split-ubiquitin membrane yeast two-hybrid system.
|
| |
Mol Cell Proteomics,
7,
1362-1377.
|
|
|
|
|
|
|
A.S.Fanning,
M.F.Lye,
J.M.Anderson,
and
A.Lavie
(2007).
Domain swapping within PDZ2 is responsible for dimerization of ZO proteins.
|
| |
J Biol Chem,
282,
37710-37716.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.M.Elkins,
E.Papagrigoriou,
G.Berridge,
X.Yang,
C.Phillips,
C.Gileadi,
P.Savitsky,
and
D.A.Doyle
(2007).
Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
|
| |
Protein Sci,
16,
683-694.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.Langnaese,
K.Richter,
K.H.Smalla,
M.Krauss,
U.Thomas,
G.Wolf,
and
G.Laube
(2007).
Splice-isoform specific immunolocalization of neuronal nitric oxide synthase in mouse and rat brain reveals that the PDZ-complex-building nNOSalpha beta-finger is largely exposed to antibodies.
|
| |
Dev Neurobiol,
67,
422-437.
|
|
|
|
|
|
|
P.Boisguerin,
B.Ay,
G.Radziwill,
R.D.Fritz,
K.Moelling,
and
R.Volkmer
(2007).
Characterization of a putative phosphorylation switch: adaptation of SPOT synthesis to analyze PDZ domain regulation mechanisms.
|
| |
Chembiochem,
8,
2302-2307.
|
|
|
|
|
|
|
P.Pacher,
J.S.Beckman,
and
L.Liaudet
(2007).
Nitric oxide and peroxynitrite in health and disease.
|
| |
Physiol Rev,
87,
315-424.
|
|
|
|
|
|
|
Q.Chen,
X.Niu,
Y.Xu,
J.Wu,
and
Y.Shi
(2007).
Solution structure and backbone dynamics of the AF-6 PDZ domain/Bcr peptide complex.
|
| |
Protein Sci,
16,
1053-1062.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
S.P.Lad,
G.Yang,
D.A.Scott,
G.Wang,
P.Nair,
J.Mathison,
V.S.Reddy,
and
E.Li
(2007).
Chlamydial CT441 is a PDZ domain-containing tail-specific protease that interferes with the NF-kappaB pathway of immune response.
|
| |
J Bacteriol,
189,
6619-6625.
|
|
|
|
|
|
|
T.Sugi,
T.Oyama,
T.Muto,
S.Nakanishi,
K.Morikawa,
and
H.Jingami
(2007).
Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation.
|
| |
EMBO J,
26,
2192-2205.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
Y.Kato
(2007).
Xenobiotic transporter-adaptor network.
|
| |
Drug Metab Pharmacokinet,
22,
401-408.
|
|
|
|
|
|
|
Y.Zhang,
B.A.Appleton,
P.Wu,
C.Wiesmann,
and
S.S.Sidhu
(2007).
Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain.
|
| |
Protein Sci,
16,
1738-1750.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.Piserchio,
M.Spaller,
and
D.F.Mierke
(2006).
Targeting the PDZ domains of molecular scaffolds of transmembrane ion channels.
|
| |
AAPS J,
8,
E396-E401.
|
|
|
|
|
|
|
B.J.Hillier,
V.Sundaresan,
C.D.Stout,
and
V.D.Vacquier
(2006).
Expression, purification, crystallization and preliminary X-ray analysis of the olfactomedin domain from the sea urchin cell-adhesion protein amassin.
|
| |
Acta Crystallogr Sect F Struct Biol Cryst Commun,
62,
16-19.
|
|
|
|
|
|
|
M.C.Hammond,
B.Z.Harris,
W.A.Lim,
and
P.A.Bartlett
(2006).
Beta strand peptidomimetics as potent PDZ domain ligands.
|
| |
Chem Biol,
13,
1247-1251.
|
|
|
|
|
|
|
M.Joshi,
C.Vargas,
P.Boisguerin,
A.Diehl,
G.Krause,
P.Schmieder,
K.Moelling,
V.Hagen,
M.Schade,
and
H.Oschkinat
(2006).
Discovery of low-molecular-weight ligands for the AF6 PDZ domain.
|
| |
Angew Chem Int Ed Engl,
45,
3790-3795.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
N.Basdevant,
H.Weinstein,
and
M.Ceruso
(2006).
Thermodynamic basis for promiscuity and selectivity in protein-protein interactions: PDZ domains, a case study.
|
| |
J Am Chem Soc,
128,
12766-12777.
|
|
|
|
|
|
|
P.Day,
and
B.Kobilka
(2006).
PDZ-domain arrays for identifying components of GPCR signaling complexes.
|
| |
Trends Pharmacol Sci,
27,
509-511.
|
|
|
|
|
|
|
R.H.Kedlaya,
K.M.Bhat,
J.Mitchell,
S.J.Darnell,
and
V.Setaluri
(2006).
TRP1 interacting PDZ-domain protein GIPC forms oligomers and is localized to intracellular vesicles in human melanocytes.
|
| |
Arch Biochem Biophys,
454,
160-169.
|
|
|
|
|
|
|
S.L.Dong,
M.Löweneck,
T.E.Schrader,
W.J.Schreier,
W.Zinth,
L.Moroder,
and
C.Renner
(2006).
A photocontrolled beta-hairpin peptide.
|
| |
Chemistry,
12,
1114-1120.
|
|
|
|
|
|
|
A.E.Duquesne,
M.Ruijter,
J.Brouwer,
J.W.Drijfhout,
S.B.Nabuurs,
C.A.Spronk,
G.W.Vuister,
M.Ubbink,
and
G.W.Canters
(2005).
Solution structure of the second PDZ domain of the neuronal adaptor X11alpha and its interaction with the C-terminal peptide of the human copper chaperone for superoxide dismutase.
|
| |
J Biomol NMR,
32,
209-218.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.Yesilaltay,
O.Kocher,
A.Rigotti,
and
M.Krieger
(2005).
Regulation of SR-BI-mediated high-density lipoprotein metabolism by the tissue-specific adaptor protein PDZK1.
|
| |
Curr Opin Lipidol,
16,
147-152.
|
|
|
|
|
|
|
C.Sun,
and
D.F.Mierke
(2005).
Characterization of interactions of Na+/H+ exchanger regulatory factor-1 with the parathyroid hormone receptor and phospholipase C.
|
| |
J Pept Res,
65,
411-417.
|
|
|
|
|
|
|
E.R.Simpson,
J.K.Meldrum,
R.Bofill,
M.D.Crespo,
E.Holmes,
and
M.S.Searle
(2005).
Engineering enhanced protein stability through beta-turn optimization: insights for the design of stable peptide beta-hairpin systems.
|
| |
Angew Chem Int Ed Engl,
44,
4939-4944.
|
|
|
|
|
|
|
L.Funke,
S.Dakoji,
and
D.S.Bredt
(2005).
Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions.
|
| |
Annu Rev Biochem,
74,
219-245.
|
|
|
|
|
|
|
M.Du,
X.Fan,
T.Hanada,
H.Gao,
M.Lutchman,
J.L.Brandsma,
A.H.Chishti,
and
J.J.Chen
(2005).
Association of cottontail rabbit papillomavirus E6 oncoproteins with the hDlg/SAP97 tumor suppressor.
|
| |
J Cell Biochem,
94,
1038-1045.
|
|
|
|
|
|
|
P.De Los Rios,
F.Cecconi,
A.Pretre,
G.Dietler,
O.Michielin,
F.Piazza,
and
B.Juanico
(2005).
Functional dynamics of PDZ binding domains: a normal-mode analysis.
|
| |
Biophys J,
89,
14-21.
|
|
|
|
|
|
|
S.Luo,
Y.Chen,
K.O.Lai,
J.C.Arévalo,
S.C.Froehner,
M.E.Adams,
M.V.Chao,
and
N.Y.Ip
(2005).
{alpha}-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner.
|
| |
J Cell Biol,
169,
813-824.
|
|
|
|
|
|
|
T.Cierpicki,
J.H.Bushweller,
and
Z.S.Derewenda
(2005).
Probing the supramodular architecture of a multidomain protein: the structure of syntenin in solution.
|
| |
Structure,
13,
319-327.
|
|
|
|
|
|
|
T.Haenggi,
M.C.Schaub,
and
J.M.Fritschy
(2005).
Molecular heterogeneity of the dystrophin-associated protein complex in the mouse kidney nephron: differential alterations in the absence of utrophin and dystrophin.
|
| |
Cell Tissue Res,
319,
299-313.
|
|
|
|
|
|
|
V.Papayannopoulos,
C.Co,
K.E.Prehoda,
S.Snapper,
J.Taunton,
and
W.A.Lim
(2005).
A polybasic motif allows N-WASP to act as a sensor of PIP(2) density.
|
| |
Mol Cell,
17,
181-191.
|
|
|
|
|
|
|
C.L.Kielkopf,
S.Lücke,
and
M.R.Green
(2004).
U2AF homology motifs: protein recognition in the RRM world.
|
| |
Genes Dev,
18,
1513-1526.
|
|
|
|
|
|
|
F.C.Peterson,
R.R.Penkert,
B.F.Volkman,
and
K.E.Prehoda
(2004).
Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition.
|
| |
Mol Cell,
13,
665-676.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.K.Dev
(2004).
Making protein interactions druggable: targeting PDZ domains.
|
| |
Nat Rev Drug Discov,
3,
1047-1056.
|
|
|
|
|
|
|
K.Kristiansen
(2004).
Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function.
|
| |
Pharmacol Ther,
103,
21-80.
|
|
|
|
|
|
|
L.C.van den Berk,
M.A.van Ham,
M.M.te Lindert,
T.Walma,
J.Aelen,
G.W.Vuister,
and
W.J.Hendriks
(2004).
The interaction of PTP-BL PDZ domains with RIL: an enigmatic role for the RIL LIM domain.
|
| |
Mol Biol Rep,
31,
203-215.
|
|
|
|
|
|
|
N.Hernando,
C.A.Wagner,
S.M.Gisler,
J.Biber,
and
H.Murer
(2004).
PDZ proteins and proximal ion transport.
|
| |
Curr Opin Nephrol Hypertens,
13,
569-574.
|
|
|
|
|
|
|
R.R.Penkert,
H.M.DiVittorio,
and
K.E.Prehoda
(2004).
Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex.
|
| |
Nat Struct Mol Biol,
11,
1122-1127.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.W.McGee,
and
D.S.Bredt
(2003).
Assembly and plasticity of the glutamatergic postsynaptic specialization.
|
| |
Curr Opin Neurobiol,
13,
111-118.
|
|
|
|
|
|
|
B.S.Kang,
D.R.Cooper,
Y.Devedjiev,
U.Derewenda,
and
Z.S.Derewenda
(2003).
Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm.
|
| |
Structure,
11,
845-853.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
C.C.Yun
(2003).
Concerted roles of SGK1 and the Na+/H+ exchanger regulatory factor 2 (NHERF2) in regulation of NHE3.
|
| |
Cell Physiol Biochem,
13,
29-40.
|
|
|
|
|
|
|
H.C.Wong,
A.Bourdelas,
A.Krauss,
H.J.Lee,
Y.Shao,
D.Wu,
M.Mlodzik,
D.L.Shi,
and
J.Zheng
(2003).
Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled.
|
| |
Mol Cell,
12,
1251-1260.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
K.Kanehara,
K.Ito,
and
Y.Akiyama
(2003).
YaeL proteolysis of RseA is controlled by the PDZ domain of YaeL and a Gln-rich region of RseA.
|
| |
EMBO J,
22,
6389-6398.
|
|
|
|
|
|
|
K.S.Erdmann
(2003).
The protein tyrosine phosphatase PTP-Basophil/Basophil-like. Interacting proteins and molecular functions.
|
| |
Eur J Biochem,
270,
4789-4798.
|
|
|
|
|
|
|
M.van Ham,
H.Croes,
J.Schepens,
J.Fransen,
B.Wieringa,
and
W.Hendriks
(2003).
Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL.
|
| |
Genes Cells,
8,
631-644.
|
|
|
|
|
|
|
S.M.Gisler,
S.Pribanic,
D.Bacic,
P.Forrer,
A.Gantenbein,
L.A.Sabourin,
A.Tsuji,
Z.S.Zhao,
E.Manser,
J.Biber,
and
H.Murer
(2003).
PDZK1: I. a major scaffolder in brush borders of proximal tubular cells.
|
| |
Kidney Int,
64,
1733-1745.
|
|
|
|
|
|
|
T.C.Dong,
and
S.M.Cutting
(2003).
SpoIVB-mediated cleavage of SpoIVFA could provide the intercellular signal to activate processing of Pro-sigmaK in Bacillus subtilis.
|
| |
Mol Microbiol,
49,
1425-1434.
|
|
|
|
|
|
|
V.E.Carlton,
B.Z.Harris,
E.G.Puffenberger,
A.K.Batta,
A.S.Knisely,
D.L.Robinson,
K.A.Strauss,
B.L.Shneider,
W.A.Lim,
G.Salen,
D.H.Morton,
and
L.N.Bull
(2003).
Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT.
|
| |
Nat Genet,
34,
91-96.
|
|
|
|
|
|
|
W.Feng,
Y.Shi,
M.Li,
and
M.Zhang
(2003).
Tandem PDZ repeats in glutamate receptor-interacting proteins have a novel mode of PDZ domain-mediated target binding.
|
| |
Nat Struct Biol,
10,
972-978.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
Y.Hozumi,
T.Ito,
T.Nakano,
T.Nakagawa,
M.Aoyagi,
H.Kondo,
and
K.Goto
(2003).
Nuclear localization of diacylglycerol kinase zeta in neurons.
|
| |
Eur J Neurosci,
18,
1448-1457.
|
|
|
|
|
|
|
A.S.Pupo,
and
K.P.Minneman
(2002).
Interaction of neuronal nitric oxide synthase with alpha1-adrenergic receptor subtypes in transfected HEK-293 cells.
|
| |
BMC Pharmacol,
2,
17.
|
|
|
|
|
|
|
A.T.Nies,
J.König,
Y.Cui,
M.Brom,
H.Spring,
and
D.Keppler
(2002).
Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2).
|
| |
Eur J Biochem,
269,
1866-1876.
|
|
|
|
|
|
|
F.Bladt,
A.Tafuri,
S.Gelkop,
L.Langille,
and
T.Pawson
(2002).
Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1.
|
| |
Proc Natl Acad Sci U S A,
99,
6816-6821.
|
|
|
|
|
|
|
G.Lei,
S.Xue,
N.Chéry,
Q.Liu,
J.Xu,
C.L.Kwan,
Y.P.Fu,
Y.M.Lu,
M.Liu,
K.W.Harder,
and
X.M.Yu
(2002).
Gain control of N-methyl-D-aspartate receptor activity by receptor-like protein tyrosine phosphatase alpha.
|
| |
EMBO J,
21,
2977-2989.
|
|
|
|
|
|
|
J.J.Chung,
S.Shikano,
Y.Hanyu,
and
M.Li
(2002).
Functional diversity of protein C-termini: more than zipcoding?
|
| |
Trends Cell Biol,
12,
146-150.
|
|
|
|
|
|
|
J.Siemens,
P.Kazmierczak,
A.Reynolds,
M.Sticker,
A.Littlewood-Evans,
and
U.Müller
(2002).
The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions.
|
| |
Proc Natl Acad Sci U S A,
99,
14946-14951.
|
|
|
|
|
|
|
S.H.Park,
Y.J.Im,
S.H.Rho,
J.H.Lee,
S.Yang,
E.Kim,
and
S.H.Eom
(2002).
Crystallization and preliminary X-ray crystallographic studies of the sixth PDZ domain of glutamate-receptor interacting protein 1 (GRIP1) from Rattus norvegicus.
|
| |
Acta Crystallogr D Biol Crystallogr,
58,
1063-1065.
|
|
|
|
|
|
|
A.G.Cochran
(2001).
Protein-protein interfaces: mimics and inhibitors.
|
| |
Curr Opin Chem Biol,
5,
654-659.
|
|
|
|
|
|
|
A.G.Lau,
and
R.A.Hall
(2001).
Oligomerization of NHERF-1 and NHERF-2 PDZ domains: differential regulation by association with receptor carboxyl-termini and by phosphorylation.
|
| |
Biochemistry,
40,
8572-8580.
|
|
|
|
|
|
|
A.W.McGee,
S.R.Dakoji,
O.Olsen,
D.S.Bredt,
W.A.Lim,
and
K.E.Prehoda
(2001).
Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins.
|
| |
Mol Cell,
8,
1291-1301.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
B.Z.Harris,
B.J.Hillier,
and
W.A.Lim
(2001).
Energetic determinants of internal motif recognition by PDZ domains.
|
| |
Biochemistry,
40,
5921-5930.
|
|
|
|
|
|
|
D.Blottner,
and
G.Lück
(2001).
Just in time and place: NOS/NO system assembly in neuromuscular junction formation.
|
| |
Microsc Res Tech,
55,
171-180.
|
|
|
|
|
|
|
D.L.Sherman,
C.Fabrizi,
C.S.Gillespie,
and
P.J.Brophy
(2001).
Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy.
|
| |
Neuron,
30,
677-687.
|
|
|
|
|
|
|
G.Webster,
T.Leung,
S.Karthikeyan,
G.Birrane,
and
J.A.Ladias
(2001).
Crystallographic characterization of the PDZ1 domain of the human Na+/H+ exchanger regulatory factor.
|
| |
Acta Crystallogr D Biol Crystallogr,
57,
714-716.
|
|
|
|
|
|
|
H.Li,
C.S.Raman,
P.Martásek,
B.S.Masters,
and
T.L.Poulos
(2001).
Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors.
|
| |
Biochemistry,
40,
5399-5406.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.Schuh,
S.Uldrijan,
M.Telkamp,
N.Rothlein,
and
L.Neyses
(2001).
The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I.
|
| |
J Cell Biol,
155,
201-205.
|
|
|
|
|
|
|
M.E.Adams,
H.A.Mueller,
and
S.C.Froehner
(2001).
In vivo requirement of the alpha-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4.
|
| |
J Cell Biol,
155,
113-122.
|
|
|
|
|
|
|
M.E.Kimple,
D.P.Siderovski,
and
J.Sondek
(2001).
Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA.
|
| |
EMBO J,
20,
4414-4422.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.M.Halford,
and
S.A.Stacker
(2001).
Revelations of the RYK receptor.
|
| |
Bioessays,
23,
34-45.
|
|
|
|
|
|
|
M.Sheng,
and
C.Sala
(2001).
PDZ domains and the organization of supramolecular complexes.
|
| |
Annu Rev Neurosci,
24,
1.
|
|
|
|
|
|
|
N.L.Ogihara,
G.Ghirlanda,
J.W.Bryson,
M.Gingery,
W.F.DeGrado,
and
D.Eisenberg
(2001).
Design of three-dimensional domain-swapped dimers and fibrous oligomers.
|
| |
Proc Natl Acad Sci U S A,
98,
1404-1409.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
N.T.Hoa,
J.A.Brannigan,
and
S.M.Cutting
(2001).
The PDZ domain of the SpoIVB serine peptidase facilitates multiple functions.
|
| |
J Bacteriol,
183,
4364-4373.
|
|
|
|
|
|
|
V.Raghuram,
D.O.Mak,
and
J.K.Foskett
(2001).
Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction.
|
| |
Proc Natl Acad Sci U S A,
98,
1300-1305.
|
|
|
|
|
|
|
X.Lou,
H.Yano,
F.Lee,
M.V.Chao,
and
M.G.Farquhar
(2001).
GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways.
|
| |
Mol Biol Cell,
12,
615-627.
|
|
|
|
|
|
|
Y.Miyagoe-Suzuki,
and
S.I.Takeda
(2001).
Association of neuronal nitric oxide synthase (nNOS) with alpha1-syntrophin at the sarcolemma.
|
| |
Microsc Res Tech,
55,
164-170.
|
|
|
|
|
|
|
Z.Grozdanovic
(2001).
NO message from muscle.
|
| |
Microsc Res Tech,
55,
148-153.
|
|
|
|
|
|
|
D.P.Wright,
D.I.Rosendale,
and
A.M.Robertson
(2000).
Prevotella enzymes involved in mucin oligosaccharide degradation and evidence for a small operon of genes expressed during growth on mucin.
|
| |
FEMS Microbiol Lett,
190,
73-79.
|
|
|
|
|
|
|
G.Kozlov,
K.Gehring,
and
I.Ekiel
(2000).
Solution structure of the PDZ2 domain from human phosphatase hPTP1E and its interactions with C-terminal peptides from the Fas receptor.
|
| |
Biochemistry,
39,
2572-2580.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
L.A.Van Geldre,
N.H.Fraeyman,
and
R.A.Lefebvre
(2000).
Subcellular localization of neuronal nitric oxide synthase in rat small intestine.
|
| |
Biochem Pharmacol,
60,
145-153.
|
|
|
|
|
|
|
M.E.Adams,
N.Kramarcy,
S.P.Krall,
S.G.Rossi,
R.L.Rotundo,
R.Sealock,
and
S.C.Froehner
(2000).
Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin.
|
| |
J Cell Biol,
150,
1385-1398.
|
|
|
|
|
|
|
M.F.Mehler
(2000).
Brain dystrophin, neurogenetics and mental retardation.
|
| |
Brain Res Brain Res Rev,
32,
277-307.
|
|
|
|
|
|
|
P.Wang,
Q.Zhang,
H.Tochio,
J.S.Fan,
and
M.Zhang
(2000).
Formation of a native-like beta-hairpin finger structure of a peptide from the extended PDZ domain of neuronal nitric oxide synthase in aqueous solution.
|
| |
Eur J Biochem,
267,
3116-3122.
|
|
|
|
|
|
|
S.H.Gee,
S.Quenneville,
C.R.Lombardo,
and
J.Chabot
(2000).
Single-amino acid substitutions alter the specificity and affinity of PDZ domains for their ligands.
|
| |
Biochemistry,
39,
14638-14646.
|
|
|
|
|
|
|
S.Wang,
H.Yue,
R.B.Derin,
W.B.Guggino,
and
M.Li
(2000).
Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity.
|
| |
Cell,
103,
169-179.
|
|
|
|
|
|
|
X.Wu,
K.Hepner,
S.Castelino-Prabhu,
D.Do,
M.B.Kaye,
X.J.Yuan,
J.Wood,
C.Ross,
C.L.Sawyers,
and
Y.E.Whang
(2000).
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2.
|
| |
Proc Natl Acad Sci U S A,
97,
4233-4238.
|
|
|
|
|
|
|
B.R.Crane,
R.J.Rosenfeld,
A.S.Arvai,
D.K.Ghosh,
S.Ghosh,
J.A.Tainer,
D.J.Stuehr,
and
E.D.Getzoff
(1999).
N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.
|
| |
EMBO J,
18,
6271-6281.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
D.J.Blake,
R.Hawkes,
M.A.Benson,
and
P.W.Beesley
(1999).
Different dystrophin-like complexes are expressed in neurons and glia.
|
| |
J Cell Biol,
147,
645-658.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
|
 |
Links
