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PDBsum entry 2exg
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Cell adhesion PDB id
2exg

 

 

 

 

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Contents
Protein chain
101 a.a. *
Ligands
STF
* Residue conservation analysis
PDB id:
2exg
Name: Cell adhesion
Title: Making protein-protein interactions drugable: discovery of low- molecular-weight ligands for the af6 pdz domain
Structure: Afadin. Chain: a. Fragment: pdz domain (residues 985-1079). Synonym: af-6 protein. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
NMR struc: 20 models
Authors: M.Joshi,C.Vargas,P.Boisguerin,G.Krause,M.Schade,H.Oschkinat
Key ref: M.Joshi et al. (2006). Discovery of low-molecular-weight ligands for the AF6 PDZ domain. Angew Chem Int Ed Engl, 45, 3790-3795. PubMed id: 16671149
Date:
08-Nov-05     Release date:   17-Oct-06    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P55196  (AFAD_HUMAN) -  Afadin from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1824 a.a.
101 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 5 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.?
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

 

 
Angew Chem Int Ed Engl 45:3790-3795 (2006)
PubMed id: 16671149  
 
 
Discovery of low-molecular-weight ligands for the AF6 PDZ domain.
M.Joshi, C.Vargas, P.Boisguerin, A.Diehl, G.Krause, P.Schmieder, K.Moelling, V.Hagen, M.Schade, H.Oschkinat.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21243154 C.Katz, L.Levy-Beladev, S.Rotem-Bamberger, T.Rito, S.G.Rüdiger, and A.Friedler (2011).
Studying protein-protein interactions using peptide arrays.
  Chem Soc Rev, 40, 2131-2145.  
20668766 A.Bach, N.Stuhr-Hansen, T.S.Thorsen, N.Bork, I.S.Moreira, K.Frydenvang, S.Padrah, S.B.Christensen, K.L.Madsen, H.Weinstein, U.Gether, and K.Strømgaard (2010).
Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1.
  Org Biomol Chem, 8, 4281-4288.  
20018661 T.S.Thorsen, K.L.Madsen, N.Rebola, M.Rathje, V.Anggono, A.Bach, I.S.Moreira, N.Stuhr-Hansen, T.Dyhring, D.Peters, T.Beuming, R.Huganir, H.Weinstein, C.Mulle, K.Strømgaard, L.C.Rønn, and U.Gether (2010).
Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.
  Proc Natl Acad Sci U S A, 107, 413-418.  
18780146 J.Shan, and J.J.Zheng (2009).
Optimizing Dvl PDZ domain inhibitor by exploring chemical space.
  J Comput Aided Mol Des, 23, 37-47.  
19437530 R.Volkmer (2009).
Synthesis and application of peptide arrays: quo vadis SPOT technology.
  Chembiochem, 10, 1431-1442.  
17973281 P.Boisguerin, B.Ay, G.Radziwill, R.D.Fritz, K.Moelling, and R.Volkmer (2007).
Characterization of a putative phosphorylation switch: adaptation of SPOT synthesis to analyze PDZ domain regulation mechanisms.
  Chembiochem, 8, 2302-2307.  
18078379 X.Chen, J.C.Longgood, C.Michnoff, S.Wei, D.E.Frantz, and L.Bezprozvanny (2007).
High-throughput screen for small molecule inhibitors of Mint1-PDZ domains.
  Assay Drug Dev Technol, 5, 769-783.  
17011050 K.K.Dev, and J.M.Henley (2006).
The schizophrenic faces of PICK1.
  Trends Pharmacol Sci, 27, 574-579.  
17185220 M.C.Hammond, B.Z.Harris, W.A.Lim, and P.A.Bartlett (2006).
Beta strand peptidomimetics as potent PDZ domain ligands.
  Chem Biol, 13, 1247-1251.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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