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PDBsum entry 1g29
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Sugar binding protein
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PDB id
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1g29
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* Residue conservation analysis
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PDB id:
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| Name: |
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Sugar binding protein
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Title:
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Malk
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Structure:
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Maltose transport protein malk. Chain: 1, 2. Synonym: malk. Engineered: yes
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Source:
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Thermococcus litoralis. Organism_taxid: 2265. Gene: malk. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Biol. unit:
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Dimer (from
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Resolution:
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1.90Å
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R-factor:
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0.211
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R-free:
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0.247
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Authors:
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K.Diederichs,J.Diez,G.Greller,C.Mueller,J.Breed,C.Schnell,C.Vonrhein, W.Boos,W.Welte
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Key ref:
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K.Diederichs
et al.
(2000).
Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis.
EMBO J,
19,
5951-5961.
PubMed id:
DOI:
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Date:
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18-Oct-00
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Release date:
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06-Dec-00
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PROCHECK
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Headers
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References
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Q9YGA6
(MALK_THELN) -
Trehalose/maltose import ATP-binding protein MalK from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
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Seq:
Struc:
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372 a.a.
372 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.7.5.2.1
- ABC-type maltose transporter.
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Reaction:
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D-maltose(out) + ATP + H2O = D-maltose(in) + ADP + phosphate + H+
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D-maltose(out)
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+
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ATP
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+
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H2O
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=
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D-maltose(in)
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+
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ADP
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+
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phosphate
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+
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H(+)
Bound ligand (Het Group name = )
matches with 55.56% similarity
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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EMBO J
19:5951-5961
(2000)
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PubMed id:
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Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis.
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K.Diederichs,
J.Diez,
G.Greller,
C.Müller,
J.Breed,
C.Schnell,
C.Vonrhein,
W.Boos,
W.Welte.
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ABSTRACT
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The members of the ABC transporter family transport a wide variety of molecules
into or out of cells and cellular compartments. Apart from a translocation pore,
each member possesses two similar nucleoside triphosphate-binding subunits or
domains in order to couple the energy-providing reaction with transport. In the
maltose transporter of several Gram-negative bacteria and the archaeon Thermo
coccus litoralis, the nucleoside triphosphate-binding subunit contains a
C-terminal regulatory domain. A dimer of the subunit is attached cytoplasmically
to the translocation pore. Here we report the crystal structure of this dimer
showing two bound pyrophosphate molecules at 1.9 A resolution. The dimer forms
by association of the ATPase domains, with the two regulatory domains attached
at opposite poles. Significant deviation from 2-fold symmetry is seen at the
interface of the dimer and in the regions corresponding to those residues known
to be in contact with the translocation pore. The structure and its relationship
to function are discussed in the light of known mutations from the homologous
Escherichia coli and Salmonella typhimurium proteins.
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Selected figure(s)
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Figure 5.
Figure 5 Comparison of the A- and B-view. In the A-view (A), the
interface appears to be more narrow than in the corresponding
B-view (B) due to the upward shift of the loop containing the
'lid' region, which has been clarified by including side chains
of residues 90, 93, 96 and 104. Notably, B-His95 approaches the
pyrophosphate to within hydrogen-bonding distance in the A-view,
while A-Tyr93 plays this role in the B-view. Arg47 shows a
difference in side chain conformation in the two views. Helices
2 and 3 are shifted outwards in the B-monomer by  3
Å as compared with the A-monomer.
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Figure 6.
Figure 6 The two pyrophosphate-binding sites. Hydrogen-bonding
partners of the pyrophosphates as seen in the A- and B-view are
shown. Labels A- and B- in front of the residues refer to the
two monomers. The bond length in angstroms is given as a number.
This figure was made with ISIS-DRAW.
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The above figures are
reprinted
from an Open Access publication published by Macmillan Publishers Ltd:
EMBO J
(2000,
19,
5951-5961)
copyright 2000.
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Figures were
selected
by an automated process.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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R.Yang,
Y.X.Hou,
C.A.Campbell,
K.Palaniyandi,
Q.Zhao,
A.J.Bordner,
and
X.B.Chang
(2011).
Glutamine residues in Q-loops of multidrug resistance protein MRP1 contribute to ATP binding via interaction with metal cofactor.
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Biochim Biophys Acta,
1808,
1790-1796.
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T.Eitinger,
D.A.Rodionov,
M.Grote,
and
E.Schneider
(2011).
Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions.
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FEMS Microbiol Rev,
35,
3.
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C.Wang,
I.Protasevich,
Z.Yang,
D.Seehausen,
T.Skalak,
X.Zhao,
S.Atwell,
J.Spencer Emtage,
D.R.Wetmore,
C.G.Brouillette,
and
J.F.Hunt
(2010).
Integrated biophysical studies implicate partial unfolding of NBD1 of CFTR in the molecular pathogenesis of F508del cystic fibrosis.
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Protein Sci,
19,
1932-1947.
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D.W.Urry,
K.D.Urry,
W.Szaflarski,
and
M.Nowicki
(2010).
Elastic-contractile model proteins: Physical chemistry, protein function and drug design and delivery.
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Adv Drug Deliv Rev,
62,
1404-1455.
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E.Bordignon,
M.Grote,
and
E.Schneider
(2010).
The maltose ATP-binding cassette transporter in the 21st century--towards a structural dynamic perspective on its mode of action.
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Mol Microbiol,
77,
1354-1366.
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M.Haffke,
A.Menzel,
Y.Carius,
D.Jahn,
and
D.W.Heinz
(2010).
Structures of the nucleotide-binding domain of the human ABCB6 transporter and its complexes with nucleotides.
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Acta Crystallogr D Biol Crystallogr,
66,
979-987.
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PDB codes:
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T.Gheyi,
L.Rodgers,
R.Romero,
J.M.Sauder,
and
S.K.Burley
(2010).
Mass spectrometry guided in situ proteolysis to obtain crystals for X-ray structure determination.
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J Am Soc Mass Spectrom,
21,
1795-1801.
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J.P.Mornon,
P.Lehn,
and
I.Callebaut
(2009).
Molecular models of the open and closed states of the whole human CFTR protein.
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Cell Mol Life Sci,
66,
3469-3486.
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M.Gonzalez-Pons,
A.C.Szeto,
R.Gonzalez-Mendez,
and
A.E.Serrano
(2009).
Identification and bioinformatic characterization of a multidrug resistance associated protein (ABCC) gene in Plasmodium berghei.
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Malar J,
8,
1.
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S.Newstead,
P.W.Fowler,
P.Bilton,
E.P.Carpenter,
P.J.Sadler,
D.J.Campopiano,
M.S.Sansom,
and
S.Iwata
(2009).
Insights into how nucleotide-binding domains power ABC transport.
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Structure,
17,
1213-1222.
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PDB code:
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U.A.Hellmich,
and
C.Glaubitz
(2009).
NMR and EPR studies of membrane transporters.
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Biol Chem,
390,
815-834.
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V.Kos,
and
R.C.Ford
(2009).
The ATP-binding cassette family: a structural perspective.
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Cell Mol Life Sci,
66,
3111-3126.
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Y.X.Hou,
C.Z.Li,
K.Palaniyandi,
P.M.Magtibay,
L.Homolya,
B.Sarkadi,
and
X.B.Chang
(2009).
Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport.
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Biochemistry,
48,
9122-9131.
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A.B.Karger,
S.Park,
S.Reyes,
M.Bienengraeber,
R.B.Dyer,
A.Terzic,
and
A.E.Alekseev
(2008).
Role for SUR2A ED domain in allosteric coupling within the K(ATP) channel complex.
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J Gen Physiol,
131,
185-196.
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I.Carrier,
and
P.Gros
(2008).
Investigating the role of the invariant carboxylate residues E552 and E1197 in the catalytic activity of Abcb1a (mouse Mdr3).
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FEBS J,
275,
3312-3324.
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J.Weng,
J.Ma,
K.Fan,
and
W.Wang
(2008).
The conformational coupling and translocation mechanism of vitamin B12 ATP-binding cassette transporter BtuCD.
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Biophys J,
94,
612-621.
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P.Lindberg,
and
A.Melis
(2008).
The chloroplast sulfate transport system in the green alga Chlamydomonas reinhardtii.
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Planta,
228,
951-961.
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R.Masia,
and
C.G.Nichols
(2008).
Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor.
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J Biol Chem,
283,
30322-30329.
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S.J.Lee,
M.Surma,
W.Hausner,
M.Thomm,
and
W.Boos
(2008).
The role of TrmB and TrmB-like transcriptional regulators for sugar transport and metabolism in the hyperthermophilic archaeon Pyrococcus furiosus.
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Arch Microbiol,
190,
247-256.
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C.A.McDevitt,
and
R.Callaghan
(2007).
How can we best use structural information on P-glycoprotein to design inhibitors?
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Pharmacol Ther,
113,
429-441.
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C.D.Putnam,
M.Hammel,
G.L.Hura,
and
J.A.Tainer
(2007).
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution.
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Q Rev Biophys,
40,
191-285.
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J.Lubelski,
W.N.Konings,
and
A.J.Driessen
(2007).
Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria.
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Microbiol Mol Biol Rev,
71,
463-476.
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L.Cuthbertson,
M.S.Kimber,
and
C.Whitfield
(2007).
Substrate binding by a bacterial ABC transporter involved in polysaccharide export.
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Proc Natl Acad Sci U S A,
104,
19529-19534.
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PDB code:
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P.M.Jones,
and
A.M.George
(2007).
Nucleotide-dependent allostery within the ABC transporter ATP-binding cassette: a computational study of the MJ0796 dimer.
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J Biol Chem,
282,
22793-22803.
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R.Yang,
and
X.B.Chang
(2007).
Hydrogen-bond formation of the residue in H-loop of the nucleotide binding domain 2 with the ATP in this site and/or other residues of multidrug resistance protein MRP1 plays a crucial role during ATP-dependent solute transport.
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Biochim Biophys Acta,
1768,
324-335.
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S.J.Lee,
A.Böhm,
M.Krug,
and
W.Boos
(2007).
The ABC of binding-protein-dependent transport in Archaea.
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Trends Microbiol,
15,
389-397.
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S.L.Rusch,
and
D.A.Kendall
(2007).
Oligomeric states of the SecA and SecYEG core components of the bacterial Sec translocon.
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Biochim Biophys Acta,
1768,
5.
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C.Oswald,
I.B.Holland,
and
L.Schmitt
(2006).
The motor domains of ABC-transporters. What can structures tell us?
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Naunyn Schmiedebergs Arch Pharmacol,
372,
385-399.
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D.L.Croteau,
M.J.DellaVecchia,
H.Wang,
R.J.Bienstock,
M.A.Melton,
and
B.Van Houten
(2006).
The C-terminal zinc finger of UvrA does not bind DNA directly but regulates damage-specific DNA binding.
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J Biol Chem,
281,
26370-26381.
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J.Deutscher,
C.Francke,
and
P.W.Postma
(2006).
How phosphotransferase system-related protein phosphorylation regulates carbohydrate metabolism in bacteria.
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Microbiol Mol Biol Rev,
70,
939.
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M.A.Mir,
H.S.Rajeswari,
U.Veeraraghavan,
and
P.Ajitkumar
(2006).
Molecular characterisation of ABC transporter type FtsE and FtsX proteins of Mycobacterium tuberculosis.
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Arch Microbiol,
185,
147-158.
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X.Guo,
R.W.Harrison,
and
P.C.Tai
(2006).
Nucleotide-dependent dimerization of the C-terminal domain of the ABC transporter CvaB in colicin V secretion.
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J Bacteriol,
188,
2383-2391.
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X.Guo,
X.Chen,
I.T.Weber,
R.W.Harrison,
and
P.C.Tai
(2006).
Molecular basis for differential nucleotide binding of the nucleotide-binding domain of ABC-transporter CvaB.
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Biochemistry,
45,
14473-14480.
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A.Karcher,
K.Büttner,
B.Märtens,
R.P.Jansen,
and
K.P.Hopfner
(2005).
X-ray structure of RLI, an essential twin cassette ABC ATPase involved in ribosome biogenesis and HIV capsid assembly.
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Structure,
13,
649-659.
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PDB code:
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A.L.Berger,
M.Ikuma,
and
M.J.Welsh
(2005).
Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain.
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Proc Natl Acad Sci U S A,
102,
455-460.
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G.Lu,
J.M.Westbrooks,
A.L.Davidson,
and
J.Chen
(2005).
ATP hydrolysis is required to reset the ATP-binding cassette dimer into the resting-state conformation.
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Proc Natl Acad Sci U S A,
102,
17969-17974.
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PDB codes:
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J.E.Moody,
and
P.J.Thomas
(2005).
Nucleotide binding domain interactions during the mechanochemical reaction cycle of ATP-binding cassette transporters.
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J Bioenerg Biomembr,
37,
475-479.
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L.Csanády,
K.W.Chan,
A.C.Nairn,
and
D.C.Gadsby
(2005).
Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain.
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J Gen Physiol,
125,
43-55.
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L.Cuthbertson,
J.Powers,
and
C.Whitfield
(2005).
The C-terminal domain of the nucleotide-binding domain protein Wzt determines substrate specificity in the ATP-binding cassette transporter for the lipopolysaccharide O-antigens in Escherichia coli serotypes O8 and O9a.
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J Biol Chem,
280,
30310-30319.
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M.F.Rosenberg,
R.Callaghan,
S.Modok,
C.F.Higgins,
and
R.C.Ford
(2005).
Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.
|
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J Biol Chem,
280,
2857-2862.
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S.G.Bompadre,
J.H.Cho,
X.Wang,
X.Zou,
Y.Sohma,
M.Li,
and
T.C.Hwang
(2005).
CFTR gating II: Effects of nucleotide binding on the stability of open states.
|
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J Gen Physiol,
125,
377-394.
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Z.Silva,
M.M.Sampaio,
A.Henne,
A.Böhm,
R.Gutzat,
W.Boos,
M.S.da Costa,
and
H.Santos
(2005).
The high-affinity maltose/trehalose ABC transporter in the extremely thermophilic bacterium Thermus thermophilus HB27 also recognizes sucrose and palatinose.
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J Bacteriol,
187,
1210-1218.
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A.Böhm,
and
W.Boos
(2004).
Gene regulation in prokaryotes by subcellular relocalization of transcription factors.
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Curr Opin Microbiol,
7,
151-156.
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A.L.Davidson,
and
J.Chen
(2004).
ATP-binding cassette transporters in bacteria.
|
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Annu Rev Biochem,
73,
241-268.
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C.van der Does,
and
R.Tampé
(2004).
How do ABC transporters drive transport?
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| |
Biol Chem,
385,
927-933.
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J.D.Campbell,
S.S.Deol,
F.M.Ashcroft,
I.D.Kerr,
and
M.S.Sansom
(2004).
Nucleotide-dependent conformational changes in HisP: molecular dynamics simulations of an ABC transporter nucleotide-binding domain.
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| |
Biophys J,
87,
3703-3715.
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J.Kovári,
O.Barabás,
E.Takács,
A.Békési,
Z.Dubrovay,
V.Pongrácz,
I.Zagyva,
T.Imre,
P.Szabó,
and
B.G.Vértessy
(2004).
Altered active site flexibility and a structural metal-binding site in eukaryotic dUTPase: kinetic characterization, folding, and crystallographic studies of the homotrimeric Drosophila enzyme.
|
| |
J Biol Chem,
279,
17932-17944.
|
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J.Zaitseva,
I.B.Holland,
and
L.Schmitt
(2004).
The role of CAPS buffer in expanding the crystallization space of the nucleotide-binding domain of the ABC transporter haemolysin B from Escherichia coli.
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| |
Acta Crystallogr D Biol Crystallogr,
60,
1076-1084.
|
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K.H.Wu,
and
P.C.Tai
(2004).
Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolytic activity of CvaB, an ATP-binding cassette transporter.
|
| |
J Biol Chem,
279,
901-909.
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|
|
|
K.P.Locher
(2004).
Structure and mechanism of ABC transporters.
|
| |
Curr Opin Struct Biol,
14,
426-431.
|
|
|
|
|
|
|
M.F.Rosenberg,
A.B.Kamis,
L.A.Aleksandrov,
R.C.Ford,
and
J.R.Riordan
(2004).
Purification and crystallization of the cystic fibrosis transmembrane conductance regulator (CFTR).
|
| |
J Biol Chem,
279,
39051-39057.
|
|
|
|
|
|
|
Q.Qu,
S.J.Lee,
and
W.Boos
(2004).
TreT, a novel trehalose glycosyltransferring synthase of the hyperthermophilic archaeon Thermococcus litoralis.
|
| |
J Biol Chem,
279,
47890-47897.
|
|
|
|
|
|
|
T.Ishikawa,
A.Tsuji,
K.Inui,
Y.Sai,
N.Anzai,
M.Wada,
H.Endou,
and
Y.Sumino
(2004).
The genetic polymorphism of drug transporters: functional analysis approaches.
|
| |
Pharmacogenomics,
5,
67-99.
|
|
|
|
|
|
|
T.Ose,
T.Fujie,
M.Yao,
N.Watanabe,
and
I.Tanaka
(2004).
Crystal structure of the ATP-binding cassette of multisugar transporter from Pyrococcus horikoshii OT3.
|
| |
Proteins,
57,
635-638.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
Z.E.Sauna,
K.Nandigama,
and
S.V.Ambudkar
(2004).
Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: effect of transport substrates and characterization of the post-hydrolysis transition state.
|
| |
J Biol Chem,
279,
48855-48864.
|
|
|
|
|
|
|
B.Wu,
A.Yee,
A.Pineda-Lucena,
A.Semesi,
T.A.Ramelot,
J.R.Cort,
J.W.Jung,
A.Edwards,
W.Lee,
M.Kennedy,
and
C.H.Arrowsmith
(2003).
Solution structure of ribosomal protein S28E from Methanobacterium thermoautotrophicum.
|
| |
Protein Sci,
12,
2831-2837.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
C.Randak,
and
M.J.Welsh
(2003).
An intrinsic adenylate kinase activity regulates gating of the ABC transporter CFTR.
|
| |
Cell,
115,
837-850.
|
|
|
|
|
|
|
E.A.Cartier,
S.Shen,
and
S.L.Shyng
(2003).
Modulation of the trafficking efficiency and functional properties of ATP-sensitive potassium channels through a single amino acid in the sulfonylurea receptor.
|
| |
J Biol Chem,
278,
7081-7090.
|
|
|
|
|
|
|
E.Janas,
M.Hofacker,
M.Chen,
S.Gompf,
C.van der Does,
and
R.Tampé
(2003).
The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p.
|
| |
J Biol Chem,
278,
26862-26869.
|
|
|
|
|
|
|
G.Berridge,
J.A.Walker,
R.Callaghan,
and
I.D.Kerr
(2003).
The nucleotide-binding domains of P-glycoprotein. Functional symmetry in the isolated domain demonstrated by N-ethylmaleimide labelling.
|
| |
Eur J Biochem,
270,
1483-1492.
|
|
|
|
|
|
|
I.D.Kerr,
G.Berridge,
K.J.Linton,
C.F.Higgins,
and
R.Callaghan
(2003).
Definition of the domain boundaries is critical to the expression of the nucleotide-binding domains of P-glycoprotein.
|
| |
Eur Biophys J,
32,
644-654.
|
|
|
|
|
|
|
J.Chen,
G.Lu,
J.Lin,
A.L.Davidson,
and
F.A.Quiocho
(2003).
A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle.
|
| |
Mol Cell,
12,
651-661.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.D.Campbell,
M.S.Sansom,
and
F.M.Ashcroft
(2003).
Potassium channel regulation.
|
| |
EMBO Rep,
4,
1038-1042.
|
|
|
|
|
|
|
J.M.Aramini,
Y.J.Huang,
J.R.Cort,
S.Goldsmith-Fischman,
R.Xiao,
L.Y.Shih,
C.K.Ho,
J.Liu,
B.Rost,
B.Honig,
M.A.Kennedy,
T.B.Acton,
and
G.T.Montelione
(2003).
Solution NMR structure of the 30S ribosomal protein S28E from Pyrococcus horikoshii.
|
| |
Protein Sci,
12,
2823-2830.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
K.S.McKeegan,
M.I.Borges-Walmsley,
and
A.R.Walmsley
(2003).
The structure and function of drug pumps: an update.
|
| |
Trends Microbiol,
11,
21-29.
|
|
|
|
|
|
|
M.F.Rosenberg,
A.B.Kamis,
R.Callaghan,
C.F.Higgins,
and
R.C.Ford
(2003).
Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding.
|
| |
J Biol Chem,
278,
8294-8299.
|
|
|
|
|
|
|
M.H.Lamers,
H.H.Winterwerp,
and
T.K.Sixma
(2003).
The alternating ATPase domains of MutS control DNA mismatch repair.
|
| |
EMBO J,
22,
746-756.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
P.Vergani,
A.C.Nairn,
and
D.C.Gadsby
(2003).
On the mechanism of MgATP-dependent gating of CFTR Cl- channels.
|
| |
J Gen Physiol,
121,
17-36.
|
|
|
|
|
|
|
S.Samanta,
T.Ayvaz,
M.Reyes,
H.A.Shuman,
J.Chen,
and
A.L.Davidson
(2003).
Disulfide cross-linking reveals a site of stable interaction between C-terminal regulatory domains of the two MalK subunits in the maltose transport complex.
|
| |
J Biol Chem,
278,
35265-35271.
|
|
|
|
|
|
|
U.Honisch,
and
W.G.Zumft
(2003).
Operon structure and regulation of the nos gene region of Pseudomonas stutzeri, encoding an ABC-Type ATPase for maturation of nitrous oxide reductase.
|
| |
J Bacteriol,
185,
1895-1902.
|
|
|
|
|
|
|
Y.R.Yuan,
O.Martsinkevich,
and
J.F.Hunt
(2003).
Structural characterization of an MJ1267 ATP-binding cassette crystal with a complex pattern of twinning caused by promiscuous fiber packing.
|
| |
Acta Crystallogr D Biol Crystallogr,
59,
225-238.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.C.Powe,
L.Al-Nakkash,
M.Li,
and
T.C.Hwang
(2002).
Mutation of Walker-A lysine 464 in cystic fibrosis transmembrane conductance regulator reveals functional interaction between its nucleotide-binding domains.
|
| |
J Physiol,
539,
333-346.
|
|
|
|
|
|
|
A.Iliás,
Z.Urbán,
T.L.Seidl,
O.Le Saux,
E.Sinkó,
C.D.Boyd,
B.Sarkadi,
and
A.Váradi
(2002).
Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6).
|
| |
J Biol Chem,
277,
16860-16867.
|
|
|
|
|
|
|
A.L.Davidson
(2002).
Mechanism of coupling of transport to hydrolysis in bacterial ATP-binding cassette transporters.
|
| |
J Bacteriol,
184,
1225-1233.
|
|
|
|
|
|
|
A.Schiefner,
K.Diederichs,
K.Hashimoto,
W.Boos,
and
W.Welte
(2002).
Crystallization and preliminary X-ray analysis of the trehalose/maltose ABC transporter MalFGK2 from Thermococcus litoralis.
|
| |
Acta Crystallogr D Biol Crystallogr,
58,
2147-2149.
|
|
|
|
|
|
|
A.Stein,
M.Seifert,
R.Volkmer-Engert,
J.Siepelmeyer,
K.Jahreis,
and
E.Schneider
(2002).
Functional characterization of the maltose ATP-binding-cassette transporter of Salmonella typhimurium by means of monoclonal antibodies directed against the MalK subunit.
|
| |
Eur J Biochem,
269,
4074-4085.
|
|
|
|
|
|
|
E.E.Fetsch,
and
A.L.Davidson
(2002).
Vanadate-catalyzed photocleavage of the signature motif of an ATP-binding cassette (ABC) transporter.
|
| |
Proc Natl Acad Sci U S A,
99,
9685-9690.
|
|
|
|
|
|
|
G.Verdon,
S.V.Albers,
B.W.Dijkstra,
A.J.Driessen,
and
A.M.Thunnissen
(2002).
Purification, crystallization and preliminary X-ray diffraction analysis of an archaeal ABC-ATPase.
|
| |
Acta Crystallogr D Biol Crystallogr,
58,
362-365.
|
|
|
|
|
|
|
H.Nikaido
(2002).
How are the ABC transporters energized?
|
| |
Proc Natl Acad Sci U S A,
99,
9609-9610.
|
|
|
|
|
|
|
J.E.Moody,
L.Millen,
D.Binns,
J.F.Hunt,
and
P.J.Thomas
(2002).
Cooperative, ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters.
|
| |
J Biol Chem,
277,
21111-21114.
|
|
|
|
|
|
|
J.Y.Lee,
I.L.Urbatsch,
A.E.Senior,
and
S.Wilkens
(2002).
Projection structure of P-glycoprotein by electron microscopy. Evidence for a closed conformation of the nucleotide binding domains.
|
| |
J Biol Chem,
277,
40125-40131.
|
|
|
|
|
|
|
K.Kashiwagi,
A.Innami,
R.Zenda,
H.Tomitori,
and
K.Igarashi
(2002).
The ATPase activity and the functional domain of PotA, a component of the sermidine-preferential uptake system in Escherichia coli.
|
| |
J Biol Chem,
277,
24212-24219.
|
|
|
|
|
|
|
L.Aleksandrov,
A.A.Aleksandrov,
X.B.Chang,
and
J.R.Riordan
(2002).
The First Nucleotide Binding Domain of Cystic Fibrosis Transmembrane Conductance Regulator Is a Site of Stable Nucleotide Interaction, whereas the Second Is a Site of Rapid Turnover.
|
| |
J Biol Chem,
277,
15419-15425.
|
|
|
|
|
|
|
L.Kránitz,
H.Benabdelhak,
C.Horn,
M.A.Blight,
I.B.Holland,
and
L.Schmitt
(2002).
Crystallization and preliminary X-ray analysis of the ATP-binding domain of the ABC transporter haemolysin B from Escherichia coli.
|
| |
Acta Crystallogr D Biol Crystallogr,
58,
539-541.
|
|
|
|
|
|
|
L.V.Zingman,
D.M.Hodgson,
M.Bienengraeber,
A.B.Karger,
E.C.Kathmann,
A.E.Alekseev,
and
A.Terzic
(2002).
Tandem function of nucleotide binding domains confers competence to sulfonylurea receptor in gating ATP-sensitive K+ channels.
|
| |
J Biol Chem,
277,
14206-14210.
|
|
|
|
|
|
|
M.I.Milewski,
J.E.Mickle,
J.K.Forrest,
B.A.Stanton,
and
G.R.Cutting
(2002).
Aggregation of misfolded proteins can be a selective process dependent upon peptide composition.
|
| |
J Biol Chem,
277,
34462-34470.
|
|
|
|
|
|
|
M.Matsuo,
M.Dabrowski,
K.Ueda,
and
F.M.Ashcroft
(2002).
Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding.
|
| |
EMBO J,
21,
4250-4258.
|
|
|
|
|
|
|
P.C.Smith,
N.Karpowich,
L.Millen,
J.E.Moody,
J.Rosen,
P.J.Thomas,
and
J.F.Hunt
(2002).
ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer.
|
| |
Mol Cell,
10,
139-149.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
P.M.Jones,
and
A.M.George
(2002).
Mechanism of ABC transporters: a molecular dynamics simulation of a well characterized nucleotide-binding subunit.
|
| |
Proc Natl Acad Sci U S A,
99,
12639-12644.
|
|
|
|
|
|
|
P.M.van Endert,
L.Saveanu,
E.W.Hewitt,
and
P.Lehner
(2002).
Powering the peptide pump: TAP crosstalk with energetic nucleotides.
|
| |
Trends Biochem Sci,
27,
454-461.
|
|
|
|
|
|
|
R.Kunze,
W.B.Frommer,
and
U.I.Flügge
(2002).
Metabolic engineering of plants: the role of membrane transport.
|
| |
Metab Eng,
4,
57-66.
|
|
|
|
|
|
|
T.Suárez,
S.B.Biswas,
and
E.E.Biswas
(2002).
Biochemical defects in retina-specific human ATP binding cassette transporter nucleotide binding domain 1 mutants associated with macular degeneration.
|
| |
J Biol Chem,
277,
21759-21767.
|
|
|
|
|
|
|
T.W.Loo,
M.C.Bartlett,
and
D.M.Clarke
(2002).
Introduction of the most common cystic fibrosis mutation (Delta F508) into human P-glycoprotein disrupts packing of the transmembrane segments.
|
| |
J Biol Chem,
277,
27585-27588.
|
|
|
|
|
|
|
T.W.Loo,
M.C.Bartlett,
and
D.M.Clarke
(2002).
The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence.
|
| |
J Biol Chem,
277,
41303-41306.
|
|
|
|
|
|
|
Y.X.Hou,
L.Cui,
J.R.Riordan,
and
X.B.Chang
(2002).
ATP binding to the first nucleotide-binding domain of multidrug resistance protein MRP1 increases binding and hydrolysis of ATP and trapping of ADP at the second domain.
|
| |
J Biol Chem,
277,
5110-5119.
|
|
|
|
|
|
|
A.G.Murzin,
and
A.Bateman
(2001).
CASP2 knowledge-based approach to distant homology recognition and fold prediction in CASP4.
|
| |
Proteins,
(),
76-85.
|
|
|
|
|
|
|
A.H.Hosie,
D.Allaway,
M.A.Jones,
D.L.Walshaw,
A.W.Johnston,
and
P.S.Poole
(2001).
Solute-binding protein-dependent ABC transporters are responsible for solute efflux in addition to solute uptake.
|
| |
Mol Microbiol,
40,
1449-1459.
|
|
|
|
|
|
|
A.Sharff,
C.Fanutti,
J.Shi,
C.Calladine,
and
B.Luisi
(2001).
The role of the TolC family in protein transport and multidrug efflux. From stereochemical certainty to mechanistic hypothesis.
|
| |
Eur J Biochem,
268,
5011-5026.
|
|
|
|
|
|
|
C.Andersen,
C.Hughes,
and
V.Koronakis
(2001).
Protein export and drug efflux through bacterial channel-tunnels.
|
| |
Curr Opin Cell Biol,
13,
412-416.
|
|
|
|
|
|
|
C.Geourjon,
C.Orelle,
E.Steinfels,
C.Blanchet,
G.Deléage,
A.Di Pietro,
and
J.M.Jault
(2001).
A common mechanism for ATP hydrolysis in ABC transporter and helicase superfamilies.
|
| |
Trends Biochem Sci,
26,
539-544.
|
|
|
|
|
|
|
G.Greller,
R.Riek,
and
W.Boos
(2001).
Purification and characterization of the heterologously expressed trehalose/maltose ABC transporter complex of the hyperthermophilic archaeon Thermococcus litoralis.
|
| |
Eur J Biochem,
268,
4011-4018.
|
|
|
|
|
|
|
G.Velarde,
R.C.Ford,
M.F.Rosenberg,
and
S.J.Powis
(2001).
Three-dimensional structure of transporter associated with antigen processing (TAP) obtained by single Particle image analysis.
|
| |
J Biol Chem,
276,
46054-46063.
|
|
|
|
|
|
|
J.Chen,
S.Sharma,
F.A.Quiocho,
and
A.L.Davidson
(2001).
Trapping the transition state of an ATP-binding cassette transporter: evidence for a concerted mechanism of maltose transport.
|
| |
Proc Natl Acad Sci U S A,
98,
1525-1530.
|
|
|
|
|
|
|
J.M.Falcón-Pérez,
M.Martínez-Burgos,
J.Molano,
M.J.Mazón,
and
P.Eraso
(2001).
Domain interactions in the yeast ATP binding cassette transporter Ycf1p: intragenic suppressor analysis of mutations in the nucleotide binding domains.
|
| |
J Bacteriol,
183,
4761-4770.
|
|
|
|
|
|
|
M.I.Borges-Walmsley,
and
A.R.Walmsley
(2001).
The structure and function of drug pumps.
|
| |
Trends Microbiol,
9,
71-79.
|
|
|
|
|
|
|
N.Karpowich,
O.Martsinkevich,
L.Millen,
Y.R.Yuan,
P.L.Dai,
K.MacVey,
P.J.Thomas,
and
J.F.Hunt
(2001).
Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter.
|
| |
Structure,
9,
571-586.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
O.Daumke,
and
M.R.Knittler
(2001).
Functional asymmetry of the ATP-binding-cassettes of the ABC transporter TAP is determined by intrinsic properties of the nucleotide binding domains.
|
| |
Eur J Biochem,
268,
4776-4786.
|
|
|
|
|
|
|
P.J.Thomas,
and
J.F.Hunt
(2001).
A snapshot of Nature's favorite pump.
|
| |
Nat Struct Biol,
8,
920-923.
|
|
|
|
|
|
|
R.Gaudet,
and
D.C.Wiley
(2001).
Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing.
|
| |
EMBO J,
20,
4964-4972.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
S.K.Buchanan
(2001).
Type I secretion and multidrug efflux: transport through the TolC channel-tunnel.
|
| |
Trends Biochem Sci,
26,
3-6.
|
|
|
|
|
|
|
W.Hashimoto,
K.Momma,
Y.Mishima,
B.Mikami,
and
K.Murata
(2001).
Super-channel in bacteria: function and structure of a macromolecule import system mediated by a pit-dependent ABC transporter.
|
| |
Biosci Biotechnol Biochem,
65,
1949-1956.
|
|
|
|
|
|
|
Y.Mishima,
K.Momma,
W.Hashimoto,
B.Mikami,
and
K.Murata
(2001).
Super-channel in bacteria: function and structure of the macromolecule import system mediated by a pit-dependent ABC transporter.
|
| |
FEMS Microbiol Lett,
204,
215-221.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
|
|
Links
