Ligand clusters for UniProt code P35270

Ligand clusters for P35270: Sepiapterin reductase from Homo sapiens

		Top 6 (of 10) ligand clusters Cluster 1. 7 ligand types 18 ligands Cluster 2. 1 ligand type 2 ligands Cluster 3. 1 ligand type 1 ligand Cluster 4. 1 ligand type 1 ligand Cluster 5. 1 ligand type 1 ligand Cluster 6. 1 ligand type 1 ligand
Representative protein: 6i79A

Structures

PDB		Schematic diagram
6i79A
6i6pA
6i6vA
6i6cA
6i6fA

Cluster 1 contains 7 ligand types

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Ligand		Description
		1. Ligand: EDO × 8 1,2-Ethanediol PDB codes: 6i6c(A), 6i6f(A), 6i6p(A), 6i6v(A).
		2. Ligand: NAP × 5 Nadp nicotinamide-Adenine-Dinucleotide phosphate PDB codes: 6i6c(A), 6i6f(A), 6i6p(A), 6i6v(A), 6i79(A).
		3. Ligand: H4E × 1 Ethyl 4-Azanyl-3-Bromanyl-Benzoate PDB code: 6i6f(A).
		4. Ligand: H4H × 1 (1~{r},2~{s},4~{s})-~{N}-(3-Chloranyl-4-Cyano-Phenyl) sulfonylbicyclo[2.2.1]heptane-2-Carboxamide PDB code: 6i6c(A).
		5. Ligand: H4T × 1 6-Azaspiro[3.4]octan-6-Yl-[2,4-Bis(chloranyl)-6- Oxidanyl-Phenyl]methanone PDB code: 6i6p(A).
		6. Ligand: H5E × 1 6-[(4-~{Tert}-Butyl-1,3-Thiazol-2-Yl)methyl]-4,6- Diazaspiro[2.4]heptane-5,7-Dione PDB code: 6i79(A).
		7. Ligand: H6E × 1 2-[[(3~{r})-Oxan-3-Yl]methylsulfonyl]-2- Azaspiro[4.5]decane PDB code: 6i6v(A).

Cluster 2 contains 1 ligand type

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Ligand		Description
		1. Ligand: EDO × 2 1,2-Ethanediol PDB codes: 6i6c(A), 6i6f(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: EDO × 1 1,2-Ethanediol PDB code: 6i6c(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: EDO × 1 1,2-Ethanediol PDB code: 6i6f(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: EDO × 1 1,2-Ethanediol PDB code: 6i6f(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
		1. Ligand: EDO × 1 1,2-Ethanediol PDB code: 6i6f(A).