Ligand clusters for UniProt code O95819

Ligand clusters for O95819: Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2

		4 ligand clusters Cluster 1. 15 ligand types 18 ligands Cluster 2. 1 ligand type 8 ligands Cluster 3. 2 ligand types 11 ligands Cluster 4. 1 ligand type 1 ligand
Representative protein: 4oboB

Structures

PDB		Schematic diagram
4oboB
5w5qA
4u40A
4u42A
5j95A
		more ...

Cluster 1 contains 15 ligand types

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Ligand		Description
_Mg		1. Metal: _MG × 2 PDB codes: 4u40(A),
		2. Ligand: 3C8 × 3 6-[(3s)-3-(4-Methyl-1h-Pyrazol-3-Yl)piperidin-1- Yl]pyrido[3,2-D]pyrimidin-4-Amine PDB codes: 4u41(A), 4u42(A),
		3. Ligand: 2QT × 1 N-[3-(4-Aminoquinazolin-6-Yl)-5-Fluorophenyl]-2- (Pyrrolidin-1-Yl)acetamide PDB code: 4obq(A).
		4. Ligand: 2QU × 1 6-(2-Fluoropyridin-4-Yl)pyrido[3,2-D]pyrimidin-4-Amine PDB code: 4obp(A).
		5. Ligand: 2QV × 1 6-(3-Chlorophenyl)quinazolin-4-Amine PDB code: 4obo(A).
		6. Ligand: 3D8 × 1 N-(Pyridin-3-Yl)pyrrolo[2,1-F][1,2,4]triazin-4-Amine PDB code: 4u43(A).
		7. Ligand: 3D9 × 1 6-Phenyl-N-(Pyridin-4-Yl)pyrrolo[2,1-F][1,2,4]triazin- 4-Amine PDB code: 4u44(A).
		8. Ligand: 3DC × 1 6-(1h-Pyrazol-4-Yl)-N-(Pyridin-4-Yl)pyrrolo[2,1-F][1,2, 4]triazin-4-Amine PDB code: 4u45(A).
		9. Ligand: 3XM × 1 3-Hexanoyl-4-Hydroxy-5-(4-Hydroxyphenyl)pyridin-2(1h)- One PDB code: 4rvt(A).
		10. Ligand: 4P4 × 1 8-Amino-N-[1-(Cyclopropylcarbonyl)azetidin-3-Yl]-2-(3- Fluorophenyl)-1,7-Naphthyridine-5- Carboxamide PDB code: 4zk5(A).
		11. Ligand: 4QG × 1 4-[5-(4-Chlorophenyl)-1,3-Oxazol-2-Yl]benzamide PDB code: 4zp5(A).
		12. Ligand: 5DF × 1 4-{6-Amino-5-[4-(Methylsulfonyl)phenyl]pyridin-3- Yl}phenol PDB code: 5di1(A).
		13. Ligand: 6HH × 1 1-{4-[6-Amino-5-(4-Chlorophenyl)pyridin-3- Yl]phenyl}cyclopentane-1-Carboxylic acid PDB code: 5j95(A).
		14. Ligand: 9X4 × 1 (5s,7s)-N~3~-Methyl-10-[3-Methyl-3-(5-Methyl-1,3- Oxazol-2-Yl)but-1-Yn-1-Yl]-6,7-Dihydro-5h-5,7- Methanoimidazo[2,1-A][2]benzazepine-2,3-Dicarboxamide PDB code: 5w5q(A).
		15. Ligand: ANP × 1 Phosphoaminophosphonic acid-Adenylate ester PDB code: 4u40(A).

Cluster 2 contains 1 ligand type

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Ligand		Description
		1. Ligand: MES × 8 2-(N-Morpholino)-Ethanesulfonic acid PDB codes: 4obo(A), 4obp(A), 4obq(A), 4rvt(A), 4u41(A), 4u42(A), 4u44(A), 4zk5(A).

Cluster 3 contains 2 ligand types

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Ligand		Description
_Mg		1. Metal: _MG × 8 PDB codes: 4obp(A), 4obq(A), 4u40(A), 4u41(A), 4u42(A), 4u45(A), 4zk5(A).
_Na		2. Metal: _NA × 3 PDB codes: 4obo(A), 4u44(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
_Mg		1. Metal: _MG × 1 PDB code: 4u45(A).