PDBsum entry 4zp5

Transferase/inhibitor

PDB id: 4zp5

Contents

Protein chains

284 a.a.

300 a.a.

Ligands

4QG

Waters ×159

PDB id:

4zp5

Name:

Transferase/inhibitor

Title:

Map4k4 in complex with inhibitor

Structure:

Mitogen-activated protein kinase kinase kinase kinase 4. Chain: a, b. Fragment: unp residues 1-309. Synonym: hpk/gck-like kinase hgk,mapk/erk kinase kinase kinase 4, mekkk 4,nck-interacting kinase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: map4k4, hgk, kiaa0687, nik. Expressed in: simulium sp. Iridescent virus. Expression_system_taxid: 10489

Resolution:

2.29Å R-factor: 0.231 R-free: 0.264

Authors:

S.Liu

Key ref:

S.Liu Structure of map4k4 complex. To be published, .

Date:

07-May-15 Release date: 05-Oct-16

Protein chain

O95819  (M4K4_HUMAN) -  Mitogen-activated protein kinase kinase kinase kinase 4 from Homo sapiens

Seq: 1239 a.a.

Struc: 284 a.a.

Protein chain

O95819  (M4K4_HUMAN) -  Mitogen-activated protein kinase kinase kinase kinase 4 from Homo sapiens

Seq: 1239 a.a.

Struc: 300 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site