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PDBsum entry 4dkf
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Cytokine/immune system
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PDB id
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4dkf
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Contents |
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161 a.a.
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137 a.a.
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214 a.a.
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212 a.a.
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PDB id:
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| Name: |
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Cytokine/immune system
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Title:
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Crystal structure of human interleukin-34 bound to fab2
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Structure:
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Interleukin-34. Chain: a, b. Fragment: active core. Synonym: il-34. Engineered: yes. Fab2 heavy chain. Chain: h, i. Engineered: yes. Fab2 light chain.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: il34, c16orf77. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: tni pro. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
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Resolution:
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2.61Å
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R-factor:
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0.227
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R-free:
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0.256
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Authors:
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X.Ma,Y.Chen,S.Stawicki,Y.Wu,J.F.Bazan,M.A.Starovasnik
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Key ref:
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X.Ma
et al.
(2012).
Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R.
Structure,
20,
676-687.
PubMed id:
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Date:
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03-Feb-12
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Release date:
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11-Apr-12
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PROCHECK
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Headers
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References
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Q6ZMJ4
(IL34_HUMAN) -
Interleukin-34 from Homo sapiens
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Seq:
Struc:
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242 a.a.
161 a.a.
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Q6ZMJ4
(IL34_HUMAN) -
Interleukin-34 from Homo sapiens
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Seq:
Struc:
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242 a.a.
137 a.a.
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Structure
20:676-687
(2012)
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PubMed id:
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Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R.
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X.Ma,
W.Y.Lin,
Y.Chen,
S.Stawicki,
K.Mukhyala,
Y.Wu,
F.Martin,
J.F.Bazan,
M.A.Starovasnik.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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J.Elegheert,
N.Bracke,
P.Pouliot,
I.Gutsche,
A.V.Shkumatov,
N.Tarbouriech,
K.Verstraete,
A.Bekaert,
W.P.Burmeister,
D.I.Svergun,
B.N.Lambrecht,
B.Vergauwen,
and
S.N.Savvides
(2012).
Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1.
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Nat Struct Mol Biol,
19,
938-947.
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PDB codes:
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K.Verstraete,
and
S.N.Savvides
(2012).
Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases.
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Nat Rev Cancer,
12,
753-766.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
