PDBsum entry 4adf

Immune system/receptor

PDB id: 4adf

Contents

Protein chains

(+ 6 more) 188 a.a.

(+ 2 more) 145 a.a.

137 a.a.

Ligands

NAG-NAG-BMA-MAN-MAN-MAN ×4

NAG-NAG-BMA-MAN-MAN-MAN-MAN ×4

NAG-NAG-BMA-MAN-MAN ×4

PDB id:

4adf

Name:

Immune system/receptor

Title:

Crystal structure of the human colony-stimulating factor 1 (hcsf-1) cytokine in complex with the viral receptor barf1

Structure:

Secreted protein barf1. Chain: a, b, c, d, e, f, m, n, o, p, q, r. Synonym: barf1,33 kda early protein, p33. Engineered: yes. Mutation: yes. Macrophage colony-stimulating factor 1. Chain: g, h, i, j, k, l, s, t, u, v, w, x. Fragment: unp residues 33-181. Synonym: hcsf-1, csf-1, m-csf, mcsf, lanimostim, processed macrophage

Source:

Human herpesvirus 4. Organism_taxid: 10376. Strain: b95-8. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t. Homo sapiens. Human. Organism_taxid: 9606.

Resolution:

4.40Å R-factor: 0.240 R-free: 0.276

Authors:

J.Elegheert,N.Bracke,S.N.Savvides

Key ref:

J.Elegheert et al. (2012). Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1. Nat Struct Biol, 19, 938-947. PubMed id: 22902366

Date:

23-Dec-11 Release date: 22-Aug-12

Protein chains

P03228  (BARF1_EBVB9) -  Secreted protein BARF1 from Epstein-Barr virus (strain B95-8)

Seq: 221 a.a.

Struc: 188 a.a.

Protein chains

P09603  (CSF1_HUMAN) -  Macrophage colony-stimulating factor 1 from Homo sapiens

Seq: 554 a.a.

Struc: 145 a.a.

Protein chains

P09603  (CSF1_HUMAN) -  Macrophage colony-stimulating factor 1 from Homo sapiens

Seq: 554 a.a.

Struc: 137 a.a.

Nat Struct Biol 19:938-947 (2012)

PubMed id: 22902366

Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1.

J.Elegheert, N.Bracke, P.Pouliot, I.Gutsche, A.V.Shkumatov, N.Tarbouriech, K.Verstraete, A.Bekaert, W.P.Burmeister, D.I.Svergun, B.N.Lambrecht, B.Vergauwen, S.N.Savvides.

ABSTRACT

No abstract given.