 |
PDBsum entry 3q8l
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Hydrolase/DNA
|
PDB id
|
|
|
|
3q8l
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Hydrolase/DNA
|
|
|
Title:
|
|
Crystal structure of human flap endonuclease fen1 (wt) in complex with substrate 5'-flap DNA, sm3+, and k+
|
|
Structure:
|
|
Flap endonuclease 1. Chain: a. Synonym: fen-1, dnase iv, flap structure-specific endonuclease 1, maturation factor 1, mf1, hfen-1. Engineered: yes. DNA (5'- d( Ap Cp Tp Cp Tp Gp Cp Cp Tp Cp Ap Ap Gp Ap Cp Gp Gp T)-3'). Chain: d. Engineered: yes.
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Gene: fen1, rad2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: synthesized. Other_details: synthesized
|
|
Resolution:
|
|
|
2.32Å
|
R-factor:
|
0.163
|
R-free:
|
0.202
|
|
|
Authors:
|
|
S.E.Tsutakawa,S.Classen,B.R.Chapados,A.Arvai,D.L.Finger,G.Guenther, C.G.Tomlinson,P.Thompson,A.H.Sarker,B.Shen,P.K.Cooper,J.A.Grasby, J.A.Tainer
|
|
Key ref:
|
|
S.E.Tsutakawa
et al.
(2011).
Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily.
Cell,
145,
198-211.
PubMed id:
|
|
|
Date:
|
|
|
06-Jan-11
|
Release date:
|
27-Apr-11
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
P39748
(FEN1_HUMAN) -
Flap endonuclease 1 from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
380 a.a.
341 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
*
PDB and UniProt seqs differ
at 5 residue positions (black
crosses)
|
|
|
|
|
|
|
|
|
|
|
|
A-C-T-C-T-G-C-C-T-C-A-A-G-A-C-G-G-T
18 bases
|
|
|
|
T-T-G-A-G-G-C-A-G-A-G-T
12 bases
|
|
|
|
A-C-C-G-T-C-C
7 bases
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
Cell
145:198-211
(2011)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily.
|
|
S.E.Tsutakawa,
S.Classen,
B.R.Chapados,
A.S.Arvai,
L.D.Finger,
G.Guenther,
C.G.Tomlinson,
P.Thompson,
A.H.Sarker,
B.Shen,
P.K.Cooper,
J.A.Grasby,
J.A.Tainer.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
S.Classen,
G.L.Hura,
J.M.Holton,
R.P.Rambo,
I.Rodic,
P.J.McGuire,
K.Dyer,
M.Hammel,
G.Meigs,
K.A.Frankel,
and
J.A.Tainer
(2013).
Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source.
|
| |
J Appl Crystallogr,
46,
1.
|
|
|
|
|
|
|
K.Shi,
K.Kurahashi,
R.Gao,
S.E.Tsutakawa,
J.A.Tainer,
Y.Pommier,
and
H.Aihara
(2012).
Structural basis for recognition of 5'-phosphotyrosine adducts by Tdp2.
|
| |
Nat Struct Mol Biol,
19,
1372-1377.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
M.J.Schellenberg,
C.D.Appel,
S.Adhikari,
P.D.Robertson,
D.A.Ramsden,
and
R.S.Williams
(2012).
Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2.
|
| |
Nat Struct Mol Biol,
19,
1363-1371.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
R.S.Williams,
and
T.A.Kunkel
(2011).
FEN nucleases: bind, bend, fray, cut.
|
| |
Cell,
145,
171-172.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
|
|
Links
