› 8su9

Electron Microscopy
2.83Å resolution

E. coli SIR2-HerA complex (hexamer HerA bound with dodecamer Sir2)

Released:
DOI: 10.2210/pdb8su9/pdb
PDB entry 8su9 coloured by chain, front view.
PDB entry 8su9 coloured by chain, side view.
PDB entry 8su9 coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense.
Shen Z, Lin Q, Yang XY, Fosuah E, Fu TM
Mol Cell 83 4586-4599.e5 (2023)
PMID: 38096827
Related structures: EMD-40762

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero octadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-237520 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SIR2-like domain-containing protein Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 415 amino acids
Theoretical weight: 46.82 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
Nucleoside triphosphate hydrolase Chains: M, N, O, P, Q, R
Molecule details ›
Chains: M, N, O, P, Q, R
Length: 610 amino acids
Theoretical weight: 68.43 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli

Ligands and Environments

3 bound ligands:
Ligand AR6 12 x AR6
Ligand ADP 5 x ADP
Ligand MG 5 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.83Å
Relevant EMDB volumes: EMD-40762
Expression system: Escherichia coli

Quick links