› 8jc0

Electron Microscopy
3.4Å resolution

V gamma9 V delta2 TCR and CD3 complex in LMNG

Released:
DOI: 10.2210/pdb8jc0/pdb
PDB entry 8jc0 coloured by chain, front view.
PDB entry 8jc0 coloured by chain, side view.
PDB entry 8jc0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human γδ T cell receptor-CD3 complex.
Xin W, Huang B, Chi X, Liu Y, Xu M, Zhang Y, Li X, Su Q, Zhou Q
Nature (2024)
PMID: 38657677
Related structures: EMD-36149

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-243982 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
T-cell surface glycoprotein CD3 zeta chain Chains: a, b
Molecule details ›
Chains: a, b
Length: 195 amino acids
Theoretical weight: 21.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P20963 (Residues: 1-164; Coverage: 100%)
Gene names: CD247, CD3Z, T3Z, TCRZ
Sequence domains:
T-cell surface glycoprotein CD3 delta chain Chain: d
Molecule details ›
Chain: d
Length: 171 amino acids
Theoretical weight: 18.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P04234 (Residues: 1-171; Coverage: 100%)
Gene names: CD3D, T3D
Sequence domains:
T-cell surface glycoprotein CD3 epsilon chain Chains: e, f
Molecule details ›
Chains: e, f
Length: 207 amino acids
Theoretical weight: 23.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P07766 (Residues: 1-207; Coverage: 100%)
Gene names: CD3E, T3E
Sequence domains:
T-cell surface glycoprotein CD3 gamma chain Chain: g
Molecule details ›
Chain: g
Length: 182 amino acids
Theoretical weight: 20.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P09693 (Residues: 1-182; Coverage: 100%)
Gene names: CD3G, T3G
Sequence domains:
T cell receptor delta constant; T cell receptor delta variable 2 Chain: m
Molecule details ›
Chain: m
Length: 310 amino acids
Theoretical weight: 34.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: A0JD36 (Residues: 20-115; Coverage: 100%)
  • Canonical: B7Z8K6 (Residues: 1-153; Coverage: 100%)
Gene names: TRDC, TRDV2, hDV102S1
Sequence domains:
T cell receptor gamma constant 1; T cell receptor gamma variable 9 Chain: n
Molecule details ›
Chain: n
Length: 332 amino acids
Theoretical weight: 37.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q99603 (Residues: 20-121; Coverage: 99%)
  • Canonical: P0CF51 (Residues: 1-173; Coverage: 100%)
Gene names: TCRGC1, TCRGV9, TRGC1, TRGV9
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CLR 1 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-36149
Expression system: Homo sapiens

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