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Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 4 (4.5 angstrom resolution)

Source organism: Homo sapiens
Biochemical function: protein heterodimerization activity
Biological process: chromatin organization
Cellular component: chromosome

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EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00125
Domain description: Core histone H2A/H2B/H3/H4
Occurring in:
  1. Histone H3.1
  2. Histone H2A type 1-B/E
  3. Histone H2B type 1-J
The deposited structure of PDB entry 8hak contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H3.1. Showing 1 copy in chain E.
The deposited structure of PDB entry 8hak contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2A type 1-B/E. Showing 1 copy in chain G.
The deposited structure of PDB entry 8hak contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2B type 1-J. Showing 1 copy in chain H.

PF16211
Domain description: C-terminus of histone H2A
Occurring in:
  1. Histone H2A type 1-B/E
The deposited structure of PDB entry 8hak contains 2 copies of Pfam domain PF16211 (C-terminus of histone H2A) in Histone H2A type 1-B/E. Showing 1 copy in chain G.

PF15511
Domain description: Centromere kinetochore component CENP-T histone fold
Occurring in:
  1. Histone H4

PF02135
Domain description: TAZ zinc finger
Occurring in:
  1. Histone acetyltransferase p300
The deposited structure of PDB entry 8hak contains 1 copy of Pfam domain PF02135 (TAZ zinc finger) in Histone acetyltransferase p300. Showing 1 copy in chain K [auth N] (this domain is out of the observed residue ranges!).

PF00569
Domain description: Zinc finger, ZZ type
Occurring in:
  1. Histone acetyltransferase p300
The deposited structure of PDB entry 8hak contains 1 copy of Pfam domain PF00569 (Zinc finger, ZZ type) in Histone acetyltransferase p300. Showing 1 copy in chain K [auth N].

PF08214
Domain description: Histone acetylation protein
Occurring in:
  1. Histone acetyltransferase p300
The deposited structure of PDB entry 8hak contains 1 copy of Pfam domain PF08214 (Histone acetylation protein) in Histone acetyltransferase p300. Showing 1 copy in chain K [auth N].

PF06001
Domain description: CREB-binding protein/p300, atypical RING domain
Occurring in:
  1. Histone acetyltransferase p300
The deposited structure of PDB entry 8hak contains 1 copy of Pfam domain PF06001 (CREB-binding protein/p300, atypical RING domain) in Histone acetyltransferase p300. Showing 1 copy in chain K [auth N].

PF00439
Domain description: Bromodomain
Occurring in:
  1. Histone acetyltransferase p300
The deposited structure of PDB entry 8hak contains 1 copy of Pfam domain PF00439 (Bromodomain) in Histone acetyltransferase p300. Showing 1 copy in chain K [auth N].

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