› 8a7k

X-ray diffraction
1.3Å resolution

PcIDS1 in complex with Mg2+/Mn2+, IPP, and ZOL

Released:
DOI: 10.2210/pdb8a7k/pdb
PDB entry 8a7k coloured by chain, front view.
PDB entry 8a7k coloured by chain, side view.
PDB entry 8a7k coloured by chain, top view.
Source organism: Phaedon cochleariae
Primary publication:
Metal-dependent enzyme symmetry guides the biosynthetic flux of terpene precursors.
Ecker F, Vattekkatte A, Boland W, Groll M
Nat Chem (2023)
PMID: 37308711

Function and Biology Details

Reaction catalysed: 
Prenyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-216648 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Farnesyl pyrophosphate synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 346 amino acids
Theoretical weight: 39.98 KDa
Source organism: Phaedon cochleariae
Expression system: Escherichia coli
UniProt:
  • Canonical: M1JS91 (Residues: 86-429; Coverage: 80%)
Sequence domains: Polyprenyl synthetase

Ligands and Environments

5 bound ligands:
Ligand MN 6 x MN
Ligand MG 6 x MG
Ligand GOL 3 x GOL
Ligand IPE 2 x IPE
Ligand ZOL 2 x ZOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 58.08Å b: 70.48Å c: 94.9Å
α: 90° β: 91.29° γ: 90°
R-values:
R R work R free
0.144 0.142 0.168
Expression system: Escherichia coli

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