› 7zk7

Electron Microscopy
3.2Å resolution

ABCB1 L335C mutant (mABCB1) in the inward facing state bound to AAC

Released:
DOI: 10.2210/pdb7zk7/pdb
PDB entry 7zk7 coloured by chain, front view.
PDB entry 7zk7 coloured by chain, side view.
PDB entry 7zk7 coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Parey K, Januliene D, Gewering T, Moeller A
Related structures: EMD-14757

Function and Biology Details

Reactions catalysed: 
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149243 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-dependent translocase ABCB1 Chain: A
Molecule details ›
Chain: A
Length: 1328 amino acids
Theoretical weight: 146.06 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P21447 (Residues: 1-1276; Coverage: 100%)
Gene names: Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand JJI 1 x JJI
Ligand JIZ 1 x JIZ
Ligand Y01 2 x Y01
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-14757
Expression system: Komagataella pastoris

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