› 7de5

X-ray diffraction
1.55Å resolution

Crystal structure of yak lactoperoxidase at 1.55 A resolution.

Released:
DOI: 10.2210/pdb7de5/pdb
PDB entry 7de5 coloured by chain, front view.
PDB entry 7de5 coloured by chain, side view.
PDB entry 7de5 coloured by chain, top view.
Source organism: Bos grunniens
Primary publication:
Structure of Yak Lactoperoxidase at 1.55 Å Resolution.
Viswanathan V, Rani C, Ahmad N, Singh PK, Sharma P, Kaur P, Sharma S, Singh TP
Protein J 40 8-18 (2021)
PMID: 33389415

Function and Biology Details

Reaction catalysed: 
2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125871 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Lactoperoxidase Chain: A
Molecule details ›
Chain: A
Length: 595 amino acids
Theoretical weight: 67.77 KDa
Source organism: Bos grunniens
UniProt:
  • Canonical: L8ICE9 (Residues: 118-712; Coverage: 86%)
Gene name: M91_18575
Sequence domains: Animal haem peroxidase

Ligands and Environments


Cofactor: Ligand HEM 1 x HEM
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
5 bound ligands:
Ligand NAG 2 x NAG
Ligand IOD 35 x IOD
Ligand SCN 5 x SCN
Ligand CA 1 x CA
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RRCAT INDUS-2 BEAMLINE PX-BL21
Spacegroup: P21
Unit cell:
a: 53.91Å b: 78.98Å c: 67.82Å
α: 90° β: 92.96° γ: 90°
R-values:
R R work R free
0.187 0.186 0.226

Quick links

Citations

1 citations in other articles

Iodide supplementation of the anti-viral duox-lactoperoxidase activity may prevent some SARS-CoV-2 infections.
Smith et al. (2022)

1 mention without citation

Structural evidence of the oxidation of iodide ion into hyper-reactive hypoiodite ion by mammalian heme lactoperoxidase.
Singh et al. (2022)