› 6ubm

Electron Microscopy
3.3Å resolution

AAV8 Baculovirus-Sf9 produced, empty capsid

Released:
DOI: 10.2210/pdb6ubm/pdb
PDB entry 6ubm coloured by chain, front view.
PDB entry 6ubm coloured by chain, side view.
PDB entry 6ubm coloured by chain, top view.
Source organism: Adeno-associated virus - 8
Primary publication:
Methods Matter: Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors.
Rumachik NG, Malaker SA, Poweleit N, Maynard LH, Adams CM, Leib RD, Cirolia G, Thomas D, Stamnes S, Holt K, Sinn P, May AP, Paulk NK
Mol Ther Methods Clin Dev 18 98-118 (2020)
PMID: 32995354
Related structures: EMD-20710

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 60-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185014 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein Chain: A
Molecule details ›
Chain: A
Length: 519 amino acids
Theoretical weight: 58.53 KDa
Source organism: Adeno-associated virus - 8
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8JQF8 (Residues: 220-738; Coverage: 70%)
Sequence domains: Parvovirus coat protein VP2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-20710
Expression system: Spodoptera frugiperda

Quick links

Citations

18 review citations

Viral vector platforms within the gene therapy landscape.
Bulcha et al. (2021)
17 more

2 mentions without citation

Cryo-electron Microscopy of Adeno-associated Virus.
Stagg et al. (2022)
1 more