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Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain.

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Klein BJ, Ahmad S, Vann KR, Andrews FH, Mayo ZA, Bourriquen G, Bridgers JB, Zhang J, Strahl BD, Côté J, Kutateladze TG
OpenAccess logo Nucleic Acids Res 46 421-430 (2018)
Cited: 22 times
EuropePMC logo PMID: 29145630

Abstract

Yaf9 is an integral part of the NuA4 acetyltransferase and the SWR1 chromatin remodeling complexes. Here, we show that Yaf9 associates with acetylated histone H3 with high preference for H3K27ac. The crystal structure of the Yaf9 YEATS domain bound to the H3K27ac peptide reveals that the sequence C-terminal to K27ac stabilizes the complex. The side chain of K27ac inserts between two aromatic residues, mutation of which abrogates the interaction in vitro and leads in vivo to phenotypes similar to YAF9 deletion, including loss of SWR1-dependent incorporation of variant histone H2A.Z. Our findings reveal the molecular basis for the recognition of H3K27ac by a YEATS reader and underscore the importance of this interaction in mediating Yaf9 function within the NuA4 and SWR1 complexes.

Articles - 6axj mentioned but not cited (1)

  1. Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain. Klein BJ, Ahmad S, Vann KR, Andrews FH, Mayo ZA, Bourriquen G, Bridgers JB, Zhang J, Strahl BD, Côté J, Kutateladze TG. Nucleic Acids Res 46 421-430 (2018)


Reviews citing this publication (7)

  1. Old cogs, new tricks: the evolution of gene expression in a chromatin context. Talbert PB, Meers MP, Henikoff S. Nat Rev Genet 20 283-297 (2019)
  2. "Reading" a new chapter in protozoan parasite transcriptional regulation. Fleck K, Nitz M, Jeffers V. PLoS Pathog 17 e1010056 (2021)
  3. Studying Chromatin Epigenetics with Fluorescence Microscopy. Stepanov AI, Besedovskaia ZV, Moshareva MA, Lukyanov KA, Putlyaeva LV. Int J Mol Sci 23 8988 (2022)
  4. H2A Variants in Arabidopsis: Versatile Regulators of Genome Activity. Lei B, Berger F. Plant Commun 1 100015 (2020)
  5. Insights Into the Function of the NuA4 Complex in Plants. Espinosa-Cores L, Bouza-Morcillo L, Barrero-Gil J, Jiménez-Suárez V, Lázaro A, Piqueras R, Jarillo JA, Piñeiro M. Front Plant Sci 11 125 (2020)
  6. Roles of the INO80 and SWR1 Chromatin Remodeling Complexes in Plants. Wang J, Gao S, Peng X, Wu K, Yang S. Int J Mol Sci 20 (2019)
  7. The histone variant H2A.Z in gene regulation. Giaimo BD, Ferrante F, Herchenröther A, Hake SB, Borggrefe T. Epigenetics Chromatin 12 37 (2019)

Articles citing this publication (14)

  1. Arabidopsis YAF9 histone readers modulate flowering time through NuA4-complex-dependent H4 and H2A.Z histone acetylation at FLC chromatin. Crevillén P, Gómez-Zambrano Á, López JA, Vázquez J, Piñeiro M, Jarillo JA. New Phytol 222 1893-1908 (2019)
  2. Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain. Ma XR, Xu L, Xu S, Klein BJ, Wang H, Das S, Li K, Yang KS, Sohail S, Chapman A, Kutateladze TG, Shi X, Liu WR, Wen H. J Med Chem 64 10997-11013 (2021)
  3. Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex. Wang X, Ahmad S, Zhang Z, Côté J, Cai G. Nat Commun 9 1147 (2018)
  4. Taf2 mediates DNA binding of Taf14. Klein BJ, Feigerle JT, Zhang J, Ebmeier CC, Fan L, Singh RK, Wang WW, Schmitt LR, Lee T, Hansen KC, Liu WR, Wang YX, Strahl BD, Anthony Weil P, Kutateladze TG. Nat Commun 13 3177 (2022)
  5. BcTaf14 regulates growth and development, virulence, and stress responses in the phytopathogenic fungus Botrytis cinerea. Han H, Lv F, Liu Z, Chen T, Xue T, Liang W, Liu M. Mol Plant Pathol 24 849-865 (2023)
  6. Molecular Architecture of the Essential Yeast Histone Acetyltransferase Complex NuA4 Redefines Its Multimodularity. Setiaputra D, Ahmad S, Dalwadi U, Steunou AL, Lu S, Ross JD, Dong MQ, Côté J, Yip CK. Mol. Cell. Biol. 38 (2018)
  7. Structural insights into the π-π-π stacking mechanism and DNA-binding activity of the YEATS domain. Klein BJ, Vann KR, Andrews FH, Wang WW, Zhang J, Zhang Y, Beloglazkina AA, Mi W, Li Y, Li H, Shi X, Kutateladze AG, Strahl BD, Liu WR, Kutateladze TG. Nat Commun 9 4574 (2018)
  8. Structure and flexibility of the yeast NuA4 histone acetyltransferase complex. Zukin SA, Marunde MR, Popova IK, Soczek KM, Nogales E, Patel AB. Elife 11 e81400 (2022)
  9. A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans. Lu PYT, Kirlin AC, Aristizabal MJ, Brewis HT, Lévesque N, Setiaputra DT, Avvakumov N, Benschop JJ, Groot Koerkamp M, Holstege FCP, Krogan NJ, Yip CK, Côté J, Kobor MS. Genetics 222 iyac136 (2022)
  10. Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S. Guan H, Wang P, Zhang P, Ruan C, Ou Y, Peng B, Zheng X, Lei J, Li B, Yan C, Li H. Nature 620 669-675 (2023)
  11. Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors. Zhang J, Gundu A, Strahl BD. Genes Dev 35 1678-1692 (2021)
  12. Structure of the NuA4 acetyltransferase complex bound to the nucleosome. Qu K, Chen K, Wang H, Li X, Chen Z. Nature 610 569-574 (2022)
  13. Taf14 is required for the stabilization of transcription pre-initiation complex in Saccharomyces cerevisiae. Peil K, Jürgens H, Luige J, Kristjuhan K, Kristjuhan A. Epigenetics Chromatin 13 24 (2020)
  14. Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription. Liu B, Yang L, Zhu X, Li H, Zhu P, Wu J, Lu T, He L, Liu N, Meng S, Zhou L, Ye B, Tian Y, Fan Z. J. Exp. Med. 216 2653-2668 (2019)


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