Function and Biology Details
Reactions catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145421 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fibroblast growth factor receptor 2
Molecule details ›
Chain: A
Length: 334 amino acids
Theoretical weight: 38.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
Length: 334 amino acids
Theoretical weight: 38.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P21802 (Residues: 458-778; Coverage: 40%)
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Molecule details ›
Chain: B
Length: 114 amino acids
Theoretical weight: 13.31 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains: SH2 domain
Structure domains: SH2 domain
Length: 114 amino acids
Theoretical weight: 13.31 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical: P10686 (Residues: 661-773; Coverage: 9%)
Sequence domains: SH2 domain
Structure domains: SH2 domain
