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human PDE10A, 8-ethyl-5-methyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine, 2.03A, H3, Rfree=22.7%

Source organism: Homo sapiens
Biochemical function: phosphoric diester hydrolase activity
Biological process: signal transduction
Cellular component: not assigned

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EC 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase

Reaction catalysed:
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate
Systematic name:
3',5'-cyclic-nucleotide 5'-nucleotidohydrolase
Alternative Name(s):
  • 3', 5'-cyclic nucleoside monophosphate phosphodiesterase
  • 3',5'-cyclonucleotide phosphodiesterase
  • 3',5'-nucleotide phosphodiesterase
  • 3': 5'-monophosphate phosphodiesterase (cyclic CMP)
  • 3':5'-cyclic nucleotide 5'-nucleotidohydrolase
  • Cyclic 3',5'-mononucleotide phosphodiesterase
  • Cyclic 3',5'-nucleotide phosphodiesterase
  • Cyclic 3',5'-phosphodiesterase
  • Cyclic 3',5-nucleotide monophosphate phosphodiesterase
  • Cyclic AMP phosphodiesterase
  • Cyclic nucleotide phosphodiesterase
  • Cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP)
  • Nucleoside 3',5'-cyclic phosphate diesterase
  • Nucleoside-3',5-monophosphate phosphodiesterase
  • PDE

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

InterPro InterPro annotations
IPR023088
Domain description: 3'5'-cyclic nucleotide phosphodiesterase
Occurring in:
  1. cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
IPR003607
Domain description: HD/PDEase domain
Occurring in:
  1. cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
IPR002073
Domain description: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Occurring in:
  1. cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
IPR023174
Domain description: 3'5'-cyclic nucleotide phosphodiesterase, conserved site
Occurring in:
  1. cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
IPR036971
Domain description: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
Occurring in:
  1. cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Structure domain

CATH CATH domain
1.10.1300.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
Homology: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Occurring in:
  1. cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
The deposited structure of PDB entry 5edh contains 4 copies of CATH domain 1.10.1300.10 (Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b) in cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A. Showing 1 copy in chain B.

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