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Crystal structure of WNK3 kinase domain in a diphosphorylated state and in a complex with the inhibitor PP-121

X-ray diffraction
2.038Å resolution
PDB entry 5o2b coloured by chain, front view.
PDB entry 5o2b coloured by chain, side view.
PDB entry 5o2b coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase WNK3
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Multimeric state: monomeric
Accessible surface area: 15316.33 Å2
Buried surface area: 93.42 Å2
Dissociation area: 46.71 Å2
Dissociation energy (ΔGdiss): 6.22 kcal/mol
Dissociation entropy (TΔSdiss): -1.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-189840
Assembly 2
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Assembly Name: Serine/threonine-protein kinase WNK3
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Multimeric state: monomeric
Accessible surface area: 14314.25 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-189840

Macromolecules

Serine/threonine-protein kinase WNK3
Chains: A, B
Length: 285 amino acids
Theoretical weight: 32.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BYP7 (Residues: 132-414; Coverage: 16%)
Gene names: KIAA1566, PRKWNK3, WNK3
Pfam: Protein kinase domain
InterPro:
CATH:
Serine/threonine-protein kinase WNK3 in PDB entry 5o2b, assembly 1, front view.
Serine/threonine-protein kinase WNK3 in PDB entry 5o2b, assembly 1, side view.
Serine/threonine-protein kinase WNK3 in PDB entry 5o2b, assembly 1, top view.
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