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Crystal structure of a fusion protein containing the NBD of Hsp70 and the middle domain of Hip

Source organisms:
Biochemical function: ATP-dependent protein folding chaperone
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00012
Domain description: Hsp70 protein
Occurring in:
  1. Heat shock 70 kDa protein 1A; Hsc70-interacting protein
The deposited structure of PDB entry 4j8f contains 1 copy of Pfam domain PF00012 (Hsp70 protein) in Heat shock 70 kDa protein 1A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019734
Domain description: Tetratricopeptide repeat
Occurring in:
  1. Heat shock 70 kDa protein 1A; Hsc70-interacting protein
IPR018181
Domain description: Heat shock protein 70, conserved site
Occurring in:
  1. Heat shock 70 kDa protein 1A; Hsc70-interacting protein
IPR011990
Domain description: Tetratricopeptide-like helical domain superfamily
Occurring in:
  1. Heat shock 70 kDa protein 1A; Hsc70-interacting protein
IPR043129
Domain description: ATPase, nucleotide binding domain
Occurring in:
  1. Heat shock 70 kDa protein 1A; Hsc70-interacting protein
IPR013126
Domain description: Heat shock protein 70 family
Occurring in:
  1. Heat shock 70 kDa protein 1A; Hsc70-interacting protein

Structure domains

CATH CATH domains
3.30.420.40
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Nucleotidyltransferase; domain 5
Occurring in:
  1. Heat shock 70 kDa protein 1A; Hsc70-interacting protein
The deposited structure of PDB entry 4j8f contains 2 copies of CATH domain 3.30.420.40 (Nucleotidyltransferase; domain 5) in Heat shock 70 kDa protein 1A. Showing 2 copies in chain A.
1.25.40.10
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Tetratricopeptide repeat domain
Occurring in:
  1. Heat shock 70 kDa protein 1A; Hsc70-interacting protein
The deposited structure of PDB entry 4j8f contains 1 copy of CATH domain 1.25.40.10 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in Heat shock 70 kDa protein 1A. Showing 1 copy in chain A.
3.90.640.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Actin; Chain A, domain 4
Homology: Actin; Chain A, domain 4
Occurring in:
  1. Heat shock 70 kDa protein 1A; Hsc70-interacting protein
The deposited structure of PDB entry 4j8f contains 1 copy of CATH domain 3.90.640.10 (Actin; Chain A, domain 4) in Heat shock 70 kDa protein 1A. Showing 1 copy in chain A.

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