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Myeloperoxidase in complex with the revesible inhibitor HX1

Source organism: Homo sapiens
Biochemical function: heme binding
Biological process: response to oxidative stress
Cellular component: not assigned

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EC 1.11.2.2: Myeloperoxidase

Reaction catalysed:
Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O
Systematic name:
Chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming)
Alternative Name(s):
  • MPO
  • Verdoperoxidase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF03098
Domain description: Animal haem peroxidase
Occurring in:
  1. Myeloperoxidase heavy chain
The deposited structure of PDB entry 4c1m contains 2 copies of Pfam domain PF03098 (Animal haem peroxidase) in Myeloperoxidase heavy chain. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR019791
Domain description: Haem peroxidase, animal-type
Occurring in:
  1. Myeloperoxidase light chain
  2. Myeloperoxidase heavy chain
IPR010255
Domain description: Haem peroxidase superfamily
Occurring in:
  1. Myeloperoxidase light chain
  2. Myeloperoxidase heavy chain
IPR037120
Domain description: Haem peroxidase domain superfamily, animal type
Occurring in:
  1. Myeloperoxidase light chain
  2. Myeloperoxidase heavy chain

Structure domain

CATH CATH domain
1.10.640.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Myeloperoxidase, subunit C
Homology: Haem peroxidase domain superfamily, animal type
Occurring in:
  1. Myeloperoxidase heavy chain
The deposited structure of PDB entry 4c1m contains 2 copies of CATH domain 1.10.640.10 (Myeloperoxidase, subunit C) in Myeloperoxidase heavy chain. Showing 1 copy in chain C.

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