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Crystal structure of ANKRA2-RFX7 complex

X-ray diffraction
2.03Å resolution
PDB entry 4qqi coloured by chain, front view.
PDB entry 4qqi coloured by chain, side view.
PDB entry 4qqi coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ankyrin repeat family A protein 2 and DNA-binding protein RFX7
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Multimeric state: hetero dimer
Accessible surface area: 10707.25 Å2
Buried surface area: 2685.33 Å2
Dissociation area: 871.16 Å2
Dissociation energy (ΔGdiss): 9.27 kcal/mol
Dissociation entropy (TΔSdiss): 8.68 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-173688

Macromolecules

Ankyrin repeat family A protein 2
Chain: A
Length: 190 amino acids
Theoretical weight: 20.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H9E1 (Residues: 142-313; Coverage: 55%)
Gene names: ANKRA, ANKRA2
Pfam:
InterPro:
CATH: Ankyrin repeat-containing domain
Ankyrin repeat family A protein 2 in PDB entry 4qqi, assembly 1, front view.
Ankyrin repeat family A protein 2 in PDB entry 4qqi, assembly 1, side view.
Ankyrin repeat family A protein 2 in PDB entry 4qqi, assembly 1, top view.
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DNA-binding protein RFX7
Chain: X
Length: 17 amino acids
Theoretical weight: 2 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q2KHR2 (Residues: 182-198; Coverage: 1%)
Gene names: RFX7, RFXDC2
DNA-binding protein RFX7 in PDB entry 4qqi, assembly 1, front view.
DNA-binding protein RFX7 in PDB entry 4qqi, assembly 1, side view.
DNA-binding protein RFX7 in PDB entry 4qqi, assembly 1, top view.
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