› 4py6

X-ray diffraction
2.5Å resolution

Crystal Structure of bromodomain of PFA0510w from Plasmodium Falciparum

Released:
DOI: 10.2210/pdb4py6/pdb
PDB entry 4py6 coloured by chain, front view.
PDB entry 4py6 coloured by chain, side view.
PDB entry 4py6 coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Entry authors: Fonseca M, Tallant C, Hutchinson A, Savitsky P, Krojer T, Filippakopoulos P, Loppnau P, Brennan PE, von Delft F, Dong A, Josling GA, Duffy MF, Arrowsmith CH, Bountra C, Hui R, Knapp S, Wernimont AK, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184637 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromo domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 145 amino acids
Theoretical weight: 17.46 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q8I240 (Residues: 1172-1315; Coverage: 6%)
Gene name: PF3D7_0110500
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand R78 4 x R78
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: I222
Unit cell:
a: 74.324Å b: 84.269Å c: 219.724Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.237 0.268
Expression system: Cricetulus griseus

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