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Crystal structure of STK3 (MST2) SARAH domain

X-ray diffraction
1.4Å resolution
PDB entry 4l0n coloured by chain, front view.
PDB entry 4l0n coloured by chain, side view.
PDB entry 4l0n coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase 3 20kDa subunit
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Multimeric state: homo dimer
Accessible surface area: 7414.01 Å2
Buried surface area: 2861.43 Å2
Dissociation area: 1,430.72 Å2
Dissociation energy (ΔGdiss): 24.23 kcal/mol
Dissociation entropy (TΔSdiss): 10.9 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-171593
Assembly 2
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Assembly Name: Serine/threonine-protein kinase 3 20kDa subunit
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Multimeric state: homo dimer
Accessible surface area: 7358.84 Å2
Buried surface area: 2933.59 Å2
Dissociation area: 1,466.8 Å2
Dissociation energy (ΔGdiss): 23.75 kcal/mol
Dissociation entropy (TΔSdiss): 10.89 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-171593
Assembly 3
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Assembly Name: Serine/threonine-protein kinase 3 20kDa subunit
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Multimeric state: homo dimer
Accessible surface area: 7554.75 Å2
Buried surface area: 2799.26 Å2
Dissociation area: 1,399.63 Å2
Dissociation energy (ΔGdiss): 24.14 kcal/mol
Dissociation entropy (TΔSdiss): 10.85 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-171593
Assembly 4
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Assembly Name: Serine/threonine-protein kinase 3 20kDa subunit
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Multimeric state: homo dimer
Accessible surface area: 7647.53 Å2
Buried surface area: 2849.89 Å2
Dissociation area: 1,424.95 Å2
Dissociation energy (ΔGdiss): 21.41 kcal/mol
Dissociation entropy (TΔSdiss): 10.86 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-171593
Assembly 5
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Assembly Name: Serine/threonine-protein kinase 3 20kDa subunit
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Multimeric state: homo dimer
Accessible surface area: 7911.27 Å2
Buried surface area: 2597.92 Å2
Dissociation area: 1,298.96 Å2
Dissociation energy (ΔGdiss): 19.27 kcal/mol
Dissociation entropy (TΔSdiss): 10.89 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-171593
Assembly 6
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Assembly Name: Serine/threonine-protein kinase 3 20kDa subunit
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Multimeric state: homo dimer
Accessible surface area: 7358.15 Å2
Buried surface area: 2484.13 Å2
Dissociation area: 1,242.06 Å2
Dissociation energy (ΔGdiss): 19.85 kcal/mol
Dissociation entropy (TΔSdiss): 10.55 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-171593

Macromolecules

Serine/threonine-protein kinase 3 20kDa subunit
Chains: A, B, C, D, E, F, G, H, I, J
Length: 51 amino acids
Theoretical weight: 6.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13188 (Residues: 436-484; Coverage: 10%)
Gene names: KRS1, MST2, STK3
Pfam: C terminal SARAH domain of Mst1
InterPro:
CATH: p53-like tetramerisation domain
Serine/threonine-protein kinase 3 20kDa subunit in PDB entry 4l0n, assembly 1, front view.
Serine/threonine-protein kinase 3 20kDa subunit in PDB entry 4l0n, assembly 1, side view.
Serine/threonine-protein kinase 3 20kDa subunit in PDB entry 4l0n, assembly 1, top view.
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